ORIGINAL_ARTICLE
مرور نظام مند و فرا تحلیل پژوهش های انجام شده در حوزه شیوع مصرف مواد نیروزا در ورزشکاران ایرانی
هدف از این تحقیق مرور نظام مند و فراتحلیل پژوهش های انجام شده در زمینه شیوع مصرف مواد نیروزا در ورزشکاران ایرانی بود. در این مطالعه مروری و فراتحلیل تعداد 15 تحقیق واجد شرایط برای ورود به این مطالعه انتخاب شدند و تعداد 8078 ورزشکار در بیش از 20 رشته ورزشی در دوره های سنی نوجوانی و جوانی در این 15 مطالعه مورد بررسی قرار گرفت. پس از جمع آوری و کد گذاری اطلاعات این 15 تحقیق ،با استفاده از نرم افزار CMA همه داده ها کدگذاری و با استفاده از دو مدل ثابت و تصادفی مورد تحلیل قرار گرفتند. نتایج فراتحلیل انجام شده در این زمینه نشان داد برآورد نقطه ای مصرف مواد نیروزا بر اساس مدل تصادفی در مردان ورزشکار ایرانی 9/63 درصد و در دامنه ای بین 6/50 تا 3/75 درصد در نوسان است. همچنین شیوع مصرف مواد نیروزا در زنان ورزشکار جامعه ایرانی در یک برآورد نقطه ای بر اساس مدل ثابت برابر با 3/28 درصد و در برآورد دامنه ای در دامنه 3/25 تا 4/31 درصد بود. بیشترین میزان شیوع مصرف این مواد به ترتیب بین ورزشکاران رشته بدنسازی، وزنه برداری، کشتی، شنا و دو و میدانی بود. نتایج این تحقیق نشان داد مصرف مواد نیروزا و دوپینگ واقعیتی انکار ناپذیر بوده و امروز تنها مختص مردان ورزشکار در برخی از رشته ها نیست. دامنه این شیوع در زنان ورزشکار و جمعیت بسیار گسترده ای از ورزشکاران رشته های مختلف می باشد.بنابراین در صورت عدم توجه مسئولین، سیاستمداران و برنامه ریزان به این موضوع هر روز شاهد آسیب بیشتر جوانان و نوجوانان کشور خواهیم بود.
https://spj.ssrc.ac.ir/article_1109_026ffb2c07b0d3a01efad5438e2ccae6.pdf
2018-01-21
17
38
10.22089/spj.2017.3990.1542
دوپینگ
مواد نیروزا
شیوع
فراتحلیل
مرور نظام مند
علی
کاشی
ssrc.kashi@gmail.com
1
استادیار رفتار حرکتی، پژوهشگاه تربیت بدنی و علوم ورزشی
LEAD_AUTHOR
سعید
نقیبی
sdnaghibi@yahoo.com
2
استادیار فیزیولوژی ورزشی، دانشگاه پیام نور مرکز کرج
AUTHOR
محمد
شریعت زاده
shariatzade221@yahoo.com
3
استادیار فیزیولوژی ورزشی، پژوهشگاه تربیت بدنی و علوم ورزشی
AUTHOR
علیرضا
آقابابا
alirezaaghababa@yahoo.com
4
استادیار رفتار حرکتی، پژوهشگاه تربیت بدنی و علوم ورزشی
AUTHOR
Juhn M S. Popular sport supplement and ergogenic aids. (review). Sport Medicine. 2003; 33(12): 921-39.
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ORIGINAL_ARTICLE
تأثیر تمرین مقاومتی بر سطوح سرمی پروتئین شبه آنژیوپویتین-چهار و نیمرخ لیپیدی در زنان یائسۀ چاق
پژوهش حاضر تأثیر تمرین مقاومتی را بر سطوح پروتئین شبهآنژیوپویتین-چهار و نیمرخ لیپیدی در زنان یائسه مورد بررسی قرارداده است. بدین منظور بیست زن چاقِ (شاخص تودۀ بدن33/3± 93/30 کیلوگرم بر مترمربع، سنین 5±8/57 سال)، یائسه و کم تحرک به طور تصادفی به دو گروه تجربی (دوازده نفر) و کنترل (هشت نفر) تقسیم شدند. گروه تجربی در دوازده هفته تمرینات مقاومتی، به شکل تمرین با وزنه، سه جلسه در هفته ، شامل هشت حرکت در سه دوره با هشت تا دوازده تکرار و با شدت چهل تا شصت و پنج درصد یک تکرار بیشینه شرکت کردند. سطوح سرمی پروتئین شبهآنژیوپویتین-چهار و سطوح کلسترول، تری گلیسرید، لیپوپروتئین با چگالی زیاد ، لیپوپروتئین با چگالی کم و لیپوپروتئین با چگالی خیلی کم خون و شاخص های آنتروپومتری قبل و بیست و چهار ساعت بعد از آخرین جلسۀ تمرین اندازه گیری شدند. تجزیه و تحلیل داده ها با آزمون تی مستقل وآزمون همبستگی پیرسون درسطح معنی داری 0.05<P انجام گرفت. نتایج آزمون تی مستقل نشان داد اجرای دوازده هفته تمرینات مقاومتی میتواند سبب تفاوت معنی دار تغییرات سطوح پروتئین شبهآنژیوپویتین چهار بین گروه تجربی و کنترل گردد. از بین شاخص های آنتروپومتریک نیزتغییرات بین گروهی درصد چربی بدن معنی دار بود. بنابر نتایج آزمون همبستگی پیرسون ارتباط معنی داری بین سطوح اولیه و تغییرات پروتئین شبهآنژیوپویتین-چهار با سطوح اولیه و تغییرات فاکتورهای خونی و شاخص های آنتروپومتری پس از اجرای تمرینات مقاومتی وجود نداشت. بنابراین ممکن است؛ تمرینات مقاومتی با کاهش درصد چربی بدن و کاهش سطح سرمی پروتئین شبهآنژیوپویتین-چهار در زنان چاق یائسۀ کم تحرک، بتواند در پیشگیری و درمان چاقی و بیماری های همراه با آن نظیر بیماری های قلبی- عروقی نقش داشته باشد.
https://spj.ssrc.ac.ir/article_1105_ff9c889d6be47ac29cdfaa0776c7dd3f.pdf
2018-01-21
39
58
10.22089/spj.2018.1974.1257
تمرین مقاومتی
پروتئین شبهآنژیوپویتین-چهار
نیمرخ لیپیدی
زنان یائسه
چاقی
رحمن
سوری
rahmansoori@yahoo.com
1
دانشیار فیزیولوژی ورزشی، دانشگاه تهران
AUTHOR
نیکو
خسروی
nikukh@alzahra.ac.ir
2
دانشیار فیزیولوژی ورزشی، دانشگاه الزهرا (س)
AUTHOR
سید عباس
میرشفیعی
rezaeian.n@gmail.com
3
استاد پاتوبیولوژی، دانشگاه علوم پزشکی تهران
AUTHOR
فهیمه
قلی جانی
gholijani1392@gmail.com
4
کارشناس ارشد فیزیولوژی ورزشی، دانشگاه الزهرا (س)
LEAD_AUTHOR
نجمه
رضائیان
n.rezaeian@ut.ac.ir
5
استادیار فیزیولوژی ورزشی، دانشگاه آزاد اسلامی، واحد بجنورد
AUTHOR
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45. Staiger H, Haas C, Machann J, Werner R, Weisser M, Schick F,at.al. Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans. Diabetes. 2009 Mar; 58(3): 579–89.
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46. Mandard S1 ZF, van Straten E, Wahli W, Kuipers F, Müller M,et.al. The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem 2006 Jan 13;281(2):934-44.
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51. Boone JB Jr, Lambert CP, Flynn MG, Michaud TJ, Rodriguez-Zayas JA, Andres FF. Resistance exercise effects on plasma cortisol, testosterone and creatine kinase activity in anabolic-androgenic steroid users. Int J Sports Med 1990 Aug;11(4):293-7.
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54. Helalizade Maasoome, Gaeini abbas ali, Kordi Mohammad reza, Faraji Hakim. The Effects of 12 Weeks Combined Training on Plasma Adiponectin and IL-6 in Overweight Females. Institute of Physical Education and Sport Sciences 2016, 159-72. (In Persian).
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56
ORIGINAL_ARTICLE
افزایش ماکروفاژهای آلوئولی و سورفکتانت ریوی رت های نر جوان پس از شش هفته تمرین تناوبی
هدف این پژوهش بررسی تغییرات ماکروفاژ آلوئولی و سطوح پروتئین سورفکتانت ریوی در پی شش هفته تمرین تناوبی در رت های نر جوان بود. 15 سر موش صحرائی نر نژاد ویستار سه هفته ای با میانگین وزنی 8± 96 گرم به طور تصادفی به گروههای پایه، کنترل و تمرین تقسیم شدند. پس از دو هفته آشنایی با محیط آزمایشگاه و نوارگردان، شش هفته تمرین تناوبی را اجرا کردند. آزمودنی ها شش جلسه در هفته، هر جلسه 30 دقیقه تمرین تناوبی را اجرا کردند. یک دقیقه فعالیت شدید با دو دقیقه استراحت فعال در 10 تکرار اجرا شد. سرعت دویدن آزمودنی ها در زمان استراحت، نصف سرعت تمرین در نظر گرفته شد. اندازه گیری سطوح پروتئین سورفکتانت A با روش الایزا و درصد جمعیت ماکروفاژهای آلوئولی با استفاده از روش استریولوژی بافت ریه صورت گرفت. تجزیه و تحلیل با استفاده از آنالیز واریانس یک طرفه و آزمون LSD در سطح P≤0.05 انجام شد. شش هفته تمرین تناوبی موجب افزایش معنی دار در سطوح سورفکتانت A نسبت به گروه پایه و کنترل به ترتیب با 33.2 و 24.2 درصد شد (0.001P≤). همچنین درصد جمعیت ماکروفاژهای آلوئولی نسبت به گروه پایه و کنترل به طور معنی داری (0.001P≤) افزایش یافت (به ترتیب 660 و 11 برابر). با تأیید اثر تعاملی بین ماکروفاژهای آلوئولی و سورفکتانت A در مواجهه با فعالیت ورزشی، و نقش برجسته تر ماکروفاژهای آلوئولی نسبت به سورفکتانت A ، نقش تنظیمی سورفکتانت A در کنترل التهاب احتمالی ناشی از ورزش و حمایت از ماکروفاژهای آلوئولی مورد انتظار است.
https://spj.ssrc.ac.ir/article_1106_9934325a86136bdabdb837e4f06d411d.pdf
2018-04-29
59
72
10.22089/spj.2018.2114.1281
تمرین تناوبی
ماکروفاژهای آلوئولی
سورفکتانت
التهاب ریه
ایمنی ذاتی
شادمهر
میردار
shadmehr.mirdar@gmail.com
1
استاد فیزیولوژی ورزشی، دانشگاه مازندران
LEAD_AUTHOR
فروغ
نیستانی
fe.naiestany@yahoo.com
2
کارشناسی ارشد فیزیولوژی ورزشی، دانشگاه مازندران
AUTHOR
غلامرضا
حمیدیان
ghamidian@yahoo.com
3
استادیار بافت شناسی، دانشگاه تبریز
AUTHOR
مهدی
هدایتی
hedayati@endocrine.ac.ir
4
دانشیار بیوشیمی، پژوهشکده علوم غدد و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی
AUTHOR
Wang J, Nikrad MP, Travanty EA, Zhou B, Phang T, Gao B, et al. Innate immune response of human alveolar macrophages during influenza A infection. PLoS One. 2012;7(3): 29879.
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Woods JA, Davis JM, Mayer EP, Ghaffar A, Pate RR. Exercise increases inflammatory macrophage antitumor cytotoxicity. Journal of Applied Physiology. 1993;75(2):879-86.
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Maus UA, Janzen S, Wall G, Srivastava M, Blackwell TS, Christman JW, et al. Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. American journal of respiratory cell and molecular biology. 2006;35(2):227-35.
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Haagsman HP, Hogenkamp A, Van Eijk M, Veldhuizen EJ. Surfactant collectins and innate immunity. Neonatology. 2008;93(4):288-94.
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38
ORIGINAL_ARTICLE
تأثیر یک جلسه فعالیت تداومی و تناوبی با شدت بالا بر شاخص هایپوکسی و التهاب در بافت چربی موشهای چاق نر ویستار
هدف از انجام این تحقیق بررسی تأثیر یک جلسه فعالیت تداومی و تناوبی با شدت بالا بر سطوح HIF-1α و TNF-α در بافت چربی موشهای چاق نر ویستار بود. آزمودنیها شامل 30 سر موش 16 هفتهای چاق بود که به مدت هشت هفته از رژیم پرچرب استفاده کرده بودند. آزمون واماندهساز پیشبین حداکثر اکسیژن مصرفی برای تعیین شدت فعالیت انجام شد. سپس حیوانات به گروههای کنترل، فعالیت تداومی و HIIE تقسیم شدند. فعالیت HIIE شامل پنج وهله دو دقیقهای با شدت vVO2max100% که به وسیله چهار وهله دو دقیقهای با شدت vVO2max30% از هم جدا شده بودند. فعالیت تداومی شامل دویدن با شدت vVO2max65% بود و زمان دویدن بر اساس میزان جابهجایی در گروه تناوبی با شدت بالا محاسبه شد. مقادیر پروتئین توسط روش وسترن بلات در بافت چربی احشایی و زیرپوستی اندازهگیری و تحلیل دادهها با نرم افزار SPSS انجام شد. میزان پروتئین HIF-1α در چربی احشایی گروه تداومی نسبت به کنترل، 5/33% و در گروه HIIE 45% کاهش معنیدار داشت (P<0.001). همچنین میزان پروتئین TNF-α در هردو گروه تجربی نسبت به کنترل کاهش داشت و کاهش در گروه تداومی نسبت به HIIE به طور معنیدار بیشتر بود (P<0.001). با توجه به نتایج میتوان گفت فعالیت ورزشی، به ویژه HIIE که انجام آن برای افراد چاق سخت یا خطرناک به نظر میآید، احتمالاً منجر به افزایش هایپوکسی و التهاب بافت چربی نشده و احتمال افزایش التهاب سیستمی و مشکلات به دنبال آن را در یک جلسه فعالیت ورزشی شدید رد میکند.
https://spj.ssrc.ac.ir/article_1229_bbee5db062fa4de3d8dac0dcb0aa288b.pdf
2018-01-21
73
88
10.22089/spj.2018.2303.1311
هوازی تداومی
اینتروال
فاکتور القاء کننده هایپوکسی1
فاکتور نکروز دهنده تومور آلفا
چاقی
مریم
نورشاهی
m-nourshahi@sbu.ac.ir
1
دانشیار فیزیولوژی ورزشی، دانشگاه شهید بهشتی
AUTHOR
نازنین
ابوذری
n.aboozari@yahoo.com
2
دانشجوی دکتری فیزیولوژی ورزشی، دانشگاه شهید بهشتی
LEAD_AUTHOR
فریبا
خداقلی
khodagholi@sbmu.ac.ir
3
دانشیار مرکز تحقیقات علوم اعصاب دانشگاه علوم پزشکی، دانشگاه شهید بهشتی
AUTHOR
Ardeshir Larijani MB, Ghaneie M, Khalegh Nejhad, Baradar Jalili R. The study of body mass index in a selected population of Iran in 1379. SID. 1380 summer;3. (In persian).
1
Cullberg KB, Christiansen T, Paulsen SK, Bruun JM, Pedersen SB, Richelsen B. Effect of weight loss and exercise on angiogenic factors in the circulation and in adipose tissue in obese subjects. Obesity. 2013;21(3):454-60.
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Trayhurn P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiological Reviews. 2013;93(1):1-21.
3
Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. International Journal of Obesity. 2008;33(1):54-66.
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Ohno H, Shirato K, Sakurai T, Ogasawara J, Sumitani Y, Sato S, et al. Effect of exercise on HIF-1 and VEGF signaling. The Journal of Physical Fitness and Sports Medicine. 2012; 1(1):5-16.
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He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J. Regulation of HIF-1α activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. American Journal of Physiology-Endocrinology and Metabolism. 2011;300(5):E877-E85.
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Leggate M, Carter WG, Evans MJ, Vennard RA, Sribala-Sundaram S, Nimmo MA. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology. 2012;112(8):1353-60.
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Bulló M, García‐Lorda P, Megias I, Salas‐Salvadó J. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obesity research. 2003;11(4):525-31.
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Ballor DL, Poehlman ET. Exercise-training enhances fat-free mass preservation during diet-induced weight loss: a meta-analytical finding. International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity. 1994;18(1):35-40.
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Stiegler P, Cunliffe A. The role of diet and exercise for the maintenance of fat-free mass and resting metabolic rate during weight loss. Sports Medicine. 2006;36(3):239-62.
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Akbarnejad A, Soori R, Sayyah M, Bigdeli M, Ehteram H, Amirshagaghi F. The Comparison of the Effects of Intermittent and Continuous Training Programs on Some Selected Cardiovascular Risk Factors in Obese Young Females. SPORT BIOSCIENCES. 2011; 3(9): 77 - 93.(in persian).
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Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007;56(4):901-911
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Svenson K.L. (2004) Identification of Mouse Models of Cardiovascular Disease Using Mutagenesis. In: Ince C. (eds) The Physiological Genomics of the Critically Ill Mouse. Basic Science for the Cardiologist, vol 16. Springer, Boston, MA
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Saidpour A, Kimiagar M, Zahediasl S, Vafa M, Ghasemi A, Abadi A, et al . Effects of high-fat diets based on butter or soybean, olive or fish oil on insulin resistance and plasma desacyl-ghrelin in rats. Iranian Journal of Nutrition Sciences & Food Technology. 2011; 6 (3) :39-48. (in persian).
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Ghorbanzadeh B, Shahriari A, Fatemi Tabatabaei S.R. Preventive effect of Iranian green and black tea on diet induced obesity in rats. J.Vet.Res. 2012; 67(2): 143-148. (in persian).
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Novelli E, Diniz Y, Galhardi C, Ebaid G, Rodrigues H, Mani F, et al. Anthropometrical parameters and markers of obesity in rats. Laboratory animals. 2007;41(1):111-9.
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Leandro CG, Levada AC, Hirabara SM, Manhas-De-Castro R, De-Castro Cb, Curi R, Et Al. Aprogram Of Moderate Physical Training For Wistar Rats Based On Maximal Oxygen Consumption. The Journal of Strength & Conditioning Research. 2007;21(3):751-6.
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Haram PM, Kemi OJ, Lee SJ, Bendheim MØ, Al-Share QY, Waldum HL, et al. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovascular research. 2009;81(4):723-32.
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Heinonen I, Bucci M, Kemppainen J, Knuuti J, Nuutila P, Boushel R, et al. Regulation of subcutaneous adipose tissue blood flow during exercise in humans. Journal of applied physiology. 2012;112(6):1059-63.
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Romijn J, Coyle E, Sidossis L, Gastaldelli A, Horowitz J, Endert E, et al. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. American Journal of Physiology-Endocrinology And Metabolism. 1993;265(3):380-91.
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37
Mohamed-Ali V, Goodrick S, Rawesh A, Katz D, Miles J, Yudkin J, et al. Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α, in Vivo 1. The Journal of Clinical Endocrinology & Metabolism. 1997;82(12):4196-200
38
ORIGINAL_ARTICLE
بررسی تغییرات عوامل خطر متابولیکی قلبی عروقی متعاقب هشت هفته تمرینات استقامتی، مقاومتی و ترکیبی در کودکان چاق غیر فعال هشت تا 12 سال
هدف از این مطالعه، بررسی تغییرات مقاومت انسولینی، آدیپونکتین و عامل رشد فیبروبلاستی21 سرمی به عنوان عوامل خطر متابولیکی قلبی عروقی متعاقب هشت هفته تمرینات استقامتی، مقاومتی و ترکیبی در کودکان چاق غیر فعال 8-12 سال بود. 60 کودک پسر چاق (سن: 41/1 ± 05/10 سال و شاخص تودهی بدنی: 77/1 ± 36/32 کیلوگرم بر متر مربع) به صورت تصادفی به چهار گروه 15 نفری تمرین استقامتی، تمرین مقاومتی و تمرین ترکیبی و کنترل تقسیم شدند. تمرینات ورزشی چهار جلسه در هفته به مدت هشت هفته اجرا شد. تمرینات ترکیبی شامل دو جلسه تمرین استقامتی و دو جلسه تمرین مقاومتی به صورت مجزا بود. نمونه گیری خونی قبل و بعد از دورهی تمرینی از آزمودنی ها جهت اندازهگیری متغیرها جمع آوری شدبرای ارزیابی دادهها از آزمون تحلیل واریانس با دادههای تکراری و یک طرفه و نرم افزار اسپیاساس نسخه 21 استفاده گردید. یافته ها نشان داد مقاومت انسولینی در گروه تمرینی نسبت به گروه کنترل کاهش و میزان آدیپونکتین و عامل رشد فیبروبلاستی21 سرمی افزایش معنی دار نشان داد (P<0.001). روش تمرین استقامتی نسبت به روشهای تمرینی مقاومتی و ترکیبی باعث افزایش بیشتری در بهبود آدیپونکتین سرمی شد (P<0.001). بنابراین، میتوان گفت سه نوع تمرین ورزشی مورد استفاده در این تحقیق، به ویژه تمرین استقامتی را احتمالاً بتوان به عنوان یک روش غیردارویی جهت پیشگیری و کاهش عوامل خطر متابولیکی قلبی عروقی و اختلالات مربوط به چاقی در کودکان چاق در نظر گرفت.
https://spj.ssrc.ac.ir/article_1108_7b458d404cbc282581bccca1cdddb93c.pdf
2018-01-21
89
108
10.22089/spj.2018.2683.1361
عوامل خطر متابولیکی قلبی عروقی
تمرینات استقامتی
تمرینات مقاومتی و تمرینات ترکیبی
علیرضا
رمضانی
hosseini62@gmail.com
1
دانشیار فیزیولوژی ورزشی، دانشگاه تربیت دبیر شهید رجایی تهران
LEAD_AUTHOR
عباسعلی
گائینی
aagaeini@yahoo.com
2
استاد فیزیولوژی ورزشی، دانشگاه تهران
AUTHOR
مراد
حسینی
m.hosseini62@yahoo.com
3
دانشجوی دکتری فیزیولوژی ورزشی، دانشگاه تربیت دبیر شهید رجایی تهران
AUTHOR
جمشید
محمدی
j_mohammadi2005@gmail.com
4
دانشیار فیزیولوژی، مرکز تحقیقات گیاهان دارویی، دانشگاه علوم پزشکی یاسوج
AUTHOR
Molinari-Büchi B, Barth J, Janner M, Frey P. Overweight and obesity in children: known facts and new trends. Revue médicale suisse. 2010; 6(249):1022-5.
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3
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Besse-Patin E, Montastier C, Vinel I, Castan-Laurell K, Louche C, Dray A, et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. International Journal of Obesity. 2013;158.
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Kim KH, Kim SH, Min YK, Yang HM, Lee JB, Lee MS. Acute exercise induces FGF21 expression in mice and inhealthy humans. PloSOne. 2013; 7;8(5): 63517.
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Taniguchi H, Kumpei T, Xiaomin S, Zhen-Bo C, Satomi O, Ryuken I, et al. Cardiorespiratory Fitness and Visceral Fat Are Key Determinants of Serum Fibroblast Growth Factor 21 Concentration in Japanese Men. The Journal of Clinical Endocrinology & Metabolism. 2014 Oct; 99(10): 1877-84.
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Nazem MR, Imami A, Yaghmaei B, Shekarriz R, Hedaiati M. Serum adiponectin levels in people with low and subclinical hyperthyroid. Journal of Endocrinology and Metabolism of Iran. Shahid Beheshti University of Medical Sciences and Health Services. 2013;15(3): 279-284. (In Persian)
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Loger L, Lambert JA. Maximal multistage 20 m shuttle run test to predict V02 max. Eur J Appl Physiol 1982; 49: 1-12.
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Azucena MB, Jorge MH, Mardia LA. Diagnostic methods of insulin resistance in a pediatric population. Bol Med Hosp Infant Mex 2011;68(5):367-73.
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Arias-Loste MT, García-Unzueta MT, Llerena S, Iruzubieta P, Puente A, Cabezas J, Alonso C, et al. Plasma betatrophin levels in patients with liver cirrhosis. World journal of gastroenterology: WJG. 2015 Oct 7; 21(37): 10662.
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Avery D, Faigenbaum Ed.D, Barbara A. Resistance Training for Obese Children and Adolescents. President’s Council on Physical Fitness and Sports Washington, D.C. 2007; 8(3): 2-8.
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Frost GO, Bar-Or JD, Dyson k. Explaining differences in the metabolic cost and efficiency of treadmill locomotion in children. Journal of Sports Science. 2002; (6): 451-61.
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Katie W, Timothy WJ, Elizabeth AD, Daniel G. Exercise Training in Obese Children and Adolescents, Current Concepts. Sports Med. 2005; 35 (5): 375-392.
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Julia MK. Safe exercise prescription for children and adolescents. Paediatr Child Health. 1998; 3 (5): 337-43.
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Walter RT, Neil FG, Linda SP. ACSM’s guidelines for exercise testing and prescription. 8th ed. American College of Sports Medicine. 2010; 112-34.
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Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JFP, Dela F. Strength training increases in insulin mediated glucose uptake, GLUT4, content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes. 2004; 53: 294-305.
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Kriketos AD, Gan SK, Poynten AM, Furler SM, Chisholm DJ, Campbell LV. Exercise increases adiponectin levels and insulin sensitivity in humans. Diabetes care. 2004 Feb 1; 27(2): 629-30.
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Pan DA, Lillaja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH. Skeletal muscle triglycride levels are inversely reated to insulin action. Diabetes. 1997; 46: 983-8.
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35
ORIGINAL_ARTICLE
تأثیر تمرین هوازی و هوای آلوده به ذرات کربن سیاه بر بیان ژن IL-6 در بافتهای هیپوکمپ و قشر قدامی مغز موشهای صحرایی نر ویستار
هدف از پژوهش حاضر بررسی تأثیر تمرین هوازی و هوای آلوده به ذرات کربن سیاه بر بیان ژن اینترلوکین-شش در هیپوکمپ و قشر قدامی مغز موشهای صحرایی نر بود. 24 سر موش نر نژاد ویستار هشت تا دههفتهای بهطور تصادفی در چهار گروه الف) کنترل، ب) آلودگی، ج) تمرین و د) تمرین- آلودگی قرار گرفتند. از دستگاه تزریق ذرات و اتاقک (فالونک) بهمنظور قرارگیری حیوانات در معرض ذرات کربن سیاه با قطر کمتر از ده میکرون استفاده شد. موشهای گروههای آلودگی و تمرین- آلودگی به مدت چهار هفته (پنج روز در هفته، دو ساعت در روز) در معرض هوای آلوده به ذرات کربن سیاه قرار گرفتند. پس از هر جلسه آلودگی، گروه تمرین– آلودگی به همراه گروه تمرین به اجرای برنامه تمرین هوازی با 50 درصد سرعت بیشینه خود (60 دقیقه در هر جلسه) پرداخته و 24 ساعت پس از آخرین جلسه حیوانات قربانی شدند. با استفاده از روش ریل تایم-Pcr، بیان ژن اینترلوکین-شش بافتهای هیپوکمپ و قشر قدامی مغز موشها مورد ارزیابی قرار گرفت. جهت تعیین معنادار بودن تأثیر تمرین و آلودگی از تحلیل واریانس دوطرفه استفاده گردید. هوای آلوده به ذرات کربن سیاه منجر به افزایش معنیداری در بیان ژن اینترلوکین-شش بافتهای هیپوکمپ (0.007=P) و قشر قدامی مغز ( 0.010=P) گردید، بااینوجود تمرین هوازی تأثیر معنیداری بر بیان این ژن نداشت. باوجود عدم معنیداری تأثیر تمرین هوازی بر بیان ژن اینترلوکین-شش نتایج این تحقیق نشان داد که میزان بیان این ژن در گروههای تمرین و آلودگی- تمرین کمتر از گروه آلودگی بود. بنابراین به نظر میرسد تمرین میتواند با کاهش اینترلوکین-شش در مغز اثرات التهاب عصبی ناشی از آلودگی را تعدیل کند.
https://spj.ssrc.ac.ir/article_1230_0e6d90063e27cb5d62e78e31b390b3af.pdf
2018-01-21
109
128
10.22089/spj.2017.2858.1386
تمرین هوازی
هوای آلوده
ذرات کربن سیاه
IL-6
هیپوکمپ
قشر قدامی مغز
اکرم
کریمی اصل
akramkarimiasl@gmail.com
1
استادیار فیزیولوژی ورزشی، دانشگاه زنجان
AUTHOR
حمید
آقا علی نژاد
halinejad@modares.ac.ir
2
دانشیار فیزیولوژی ورزشی، دانشگاه تربیت مدرس
LEAD_AUTHOR
رضا
قراخانلو
ghara_re@modares.ac.ir
3
استاد فیزیولوژی ورزشی، دانشگاه تربیت مدرس
AUTHOR
بتول
رضایی
brezaee1359@yahoo.com
4
دکتری فیزیولوژی ورزشی، دانشگاه تربیت مدرس
AUTHOR
1. Zanobetti A, Schwartz J. The effect of fine and coarse particulate air pollution on mortality: a national analysis. Environmental Health Perspectives. 2009;117(6):898.
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2. Guo Y, Barnett AG, Zhang Y, Tong S, Yu W, Pan X. The short-term effect of air pollution on cardiovascular mortality in Tianjin, China: Comparison of time series and case–crossover analyses. Science of the Total Environment. 2010;409(2):300-6.
2
3. Jerrett M, Finkelstein MM, Brook JR, Arain MA, Kanaroglou P, Stieb DM, et al. A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada. Environmental Health Perspectives. 2009;117(5):772.
3
4. Wilson WE, Suh HH. Fine particles and coarse particles: concentration relationships relevant to epidemiologic studies. Journal of the Air & Waste Management Association. 1997;47(12):1238-49.
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5. Rossignol D, Genuis S, Frye R. Environmental toxicants and autism spectrum disorders: a systematic review. Translational psychiatry. 2014;4(2):e360.
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6. Levesque S, Taetzsch T, Lull ME, Kodavanti U, Stadler K, Wagner A, et al. Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. Environmental health perspectives. 2011;119(8):1149.
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7. Block ML, Calderón-Garcidueñas L. Air pollution: mechanisms of neuroinflammation and CNS disease. Trends in neurosciences. 2009;32(9):506-16.
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8. Vieira RdP, Toledo AC, Silva LB, Almeida FM, Damaceno-Rodrigues NR, Caldini EG, et al. Anti-inflammatory effects of aerobic exercise in mice exposed to air pollution. Med Sci Sports Exerc. 2012;44(7):1227-34.
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9. Plummer LE, Smiley-Jewell S, Pinkerton KE. Impact of air pollution on lung inflammation and the role of toll-like receptors. International Journal of Interferon, Cytokine and Mediator Research. 2012;4(1):43-57.
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10. van Berlo D, Albrecht C, Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, et al. Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Archives of toxicology. 2010;84(7):553-62.
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11. Bihaqi SW, Singh AP, Tiwari M. Supplementation of Convolvulus pluricaulis attenuates scopolamine-induced increased tau and Amyloid precursor protein (AβPP) expression in rat brain. Indian journal of pharmacology. 2012;44(5):593.
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12. Calderon-Garciduenas L, Cross JV, Franco-Lira M, Aragon-Flores M, Kavanaugh M, Torres-Jardon R, et al. Brain immune interactions and air pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrPC), Interleukin-6 (IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum differentiate urban children exposed to severe vs. low air pollution. Frontiers in Neuroscience. 2013;7.
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13. Calderón-Garcidueñas L, Engle R, Mora-Tiscareño A, Styner M, Gómez-Garza G, Zhu H, et al. Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children. Brain and cognition. 2011;77(3):345-55.
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14. Calderón-Garcidueñas L, D’Angiulli A, Kulesza RJ, Torres-Jardón R, Osnaya N, Romero L, et al. Air pollution is associated with brainstem auditory nuclei pathology and delayed brainstem auditory evoked potentials. International Journal of Developmental Neuroscience. 2011;29(4):365-75.
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ORIGINAL_ARTICLE
اثر پیش درمان تمرینات اینتروال همراه با ویتامین دی بر IL-10، BDNF و TNFα در مغز رت های مدل آنسفالومیلیت خود ایمن تجربی (EAE)
پژوهش حاضر با هدف بررسی اثر پیش درمان تمرینات اینتروال و ویتامین دی (D) بر فاکتور نوروتروفیک مشتق از مغز (BDNF) و TNFα در مغز رتهای مدل آنسفالومیلیت خود ایمن تجربی (EAE) انجام شد. بدین منظور، 30 سر رت نژاد لوئیس شش هفتهای، پنج روز در هفته و به مدت شش هفته تمرینات دوی اینتروال را به صورت ۱۰ تکرار ۱ دقیقهای انجام دادند. نسبت کار به استراحت ۱ به ۲ و کل زمان دویدن ۳۰ دقیقه در نظر گرفته شد. بعد از اتمام دوره تمرینی، رتها با نخاع خوکچه هندی و ادجوانت کامل ایمونیزه شدند. روند بیماری و تغییرات بالینی رتها به مدت 2 هفته بعد از القاء مدل بیماری مورد ارزیابی قرار گرفت. نتایج نشان داد رتهای ماده نژاد لوئیس مبتلا به آنسفالومیلیت خود ایمن تجربی افزایش معنی داری در اینترلوکین-10 (IL-10) (P=0.003) و کاهش معنی داری در فاکتور نکروز توموری آلفا (TNF-α) (P=0.001) داشتند اما تغییرات BDNF (P=0.62) به حد معناداری نرسید. همچنین علایم بالینی در موشها تمرین کرده با تاخیر ظاهر شد. با توجه به نتایج تحقیق حاضر، به نظر میرسد که تمرین اینتروال به مدت شش هفته به همراه ویتامین D میتواند ضمن به تاخیر انداختن بروز علایم بالینی، ذخایر شاخصهای ضدالتهابی و التهابی را در مغز مدلهای مبتلا به آنسفالومیلیت خود ایمن تجربی افزایش داده و در نتیجه به حفاظت عصبی کمک نماید.
https://spj.ssrc.ac.ir/article_1231_d0f2c861de927b7c570215fe26e2faae.pdf
2018-01-21
129
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10.22089/spj.2017.3985.1540
تمرین اینتروال
ویتامین D
ضدالتهابی
سایتوکاین
سید مجتبی
حسینی
hoseini.smojtaba@yahoo.com
1
دکتری فیزیولوژی ورزشی، دانشگاه مازندران
AUTHOR
ضیاء
فلاح محمدی
ziafalm@yahoo.com
2
دانشیار فیزیولوژی ورزشی، دانشگاه مازندران
LEAD_AUTHOR
وحید
طالبی
v.talebi@umz.ac.ir
3
دانشجوی دکتری فیزیولوژی ورزشی، دانشگاه مازندران
AUTHOR
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ORIGINAL_ARTICLE
اثر هشت هفته تمرین هوازی همراه با مصرف ژل رویال بر برخی شاخصهای قلبی عروقی طی پرفشار خونی مزمن ناشی از القای ال- نیم در موشهای نر
پرفشار خونی یکی از شایعترین علتهای ابتلا به بیماریهای قلبی عروقی است که میتوان با استفاده از راهبردهای غیردارویی همچون ورزش و مکملهای آنتی اکسیدانی آن را کنترل کرد. هدف پژوهش بررسی اثر تمرین هوازی همراه با مصرف ژل رویال بر مهارکننده آنزیم مبدل آنژیوتانسین (ACE-I) و نیتریک اکساید (NO) پلاسما و VEGF بافت قلب موشهای مبتلا به پرفشار خونی بود.42 موش صحرایی نر به صورت تصادفی به شش گروه: کنترل، شم، ال- نیم، ال- نیم+ مکمل، ال- نیم+ تمرین، ال- نیم+ مکمل+ تمرین تقسیم شدند. به جز گروه کنترل و شم سایر گروهها به مدت هشت هفته و شش جلسه در هفته محلول ال- نیم (10 میلیگرم/کیلوگرم)، برای ایجاد پرفشارخونی، به صورت زیر صفاقی دریافت کردند. تمرین نوارگردان با سرعت 15 تا 22 متر در دقیقه به مدت 25 تا 64 دقیقه پنج جلسه در هفته به مدت هشت هفته در گروه های تمرینی اجرا شد. گروههای مکمل، ژل رویال را با دوز 100 میلیگرم/کیلوگرم به مدت هشت هفته و پنج بار در هفته به صورت گاواژ دریافت کردند. سنجش شاخصها با استفاده از کیت مورد نظر و به روش الایزا انجام شد. یافتهها نشان داد تمرین هوازی و مصرف ژل در گروه ترکیبی سبب افزایش معنیدار NO و ACE-I پلاسما نسبت به گروه ال- نیم و نیز افزایش معنیدار مقادیرVEGF بافت قلب گروه تمرین و گروه ترکیبی نسبت به گروه ال- نیم (P<0.05) میشود. بر اساس نتایج، با وجود اثر مثبت تمرین و مصرف ژل بر شاخص های پژوهش، این تغییرات در گروه ترکیبی معنیدار بود که نشانگر اثر هم افزایی آنها میباشد. لذا به نظر میرسد هشت هفته تمرین به همراه مصرف ژل رویال بتواند استرس اکسیداتیو ناشی از القای ال- نیم را کاهش دهد.
https://spj.ssrc.ac.ir/article_1113_f38fb4c5a2a2340d65f64aff2621c23c.pdf
2018-01-21
143
158
10.22089/spj.2017.4127.1555
تمرین هوازی
ژل رویال
پر فشار خونی
شاخصهای قلبی عروقی
فاطمه
امیدی
eti.f.o.p.s@gmail.com
1
کارشناسی ارشد فیزیولوژی ورزشی، دانشگاه آزاد اسلامی واحد ساری
AUTHOR
سید عبداله
هاشم ورزی
hashemvarzi_tkd@yahoo.com
2
استادیار گروه فیزیولوژی ورزشی، واحد ساری، دانشگاه آزاد اسلامی، ساری، ایران
LEAD_AUTHOR
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ORIGINAL_ARTICLE
تاثیر شدت تمرین تناوبی بر مقادیر بیان ژن ANP و BNP عضله قلبی در رتها پس از ابتلا به آنفارکتوس میوکارد
آنفارکتوس میوکارد ، مرگ سلولی غیرقابل برگشت بخشی از عضله قلب است که ریشه در فقدان جریان خون دارد. مقادیر ANP و BNP نشانگرهای قوی وقوع آنفارکتوس میوکارد و شدت عارضه می باشند. لذا این پژوهش با هدف بررسی تاثیر شش هفته تمرین تناوبی خیلی شدید و تمرین تناوبی با شدت پایین بر بیان ژنهای ANP و BNP در رتها پس از ابتلا به انفارکتوس میوکارد انجام گرفت. 18 سررت نر نژاد ویستار 10 هفته ای با وزن 250 تا 300 گرم در دو گروه تجربی تمرین تناوبی خیلی شدید ( 85-90 درصد حداکثر اکسیژن مصرفی) و تمرین تناوبی با شدت پایین (55- 60 درصد حداکثر اکسیژن مصرفی) و یک گروه کنترل (بدون مداخله تمرین) قرار گرفتند. بیان ژنهای مذکور پس از ابتلای رتها به آنفارکتوس میوکارد پس از شش هفته تمرین به روش qRT-PCR بررسی شد. داده ها به روش آماری تی مستقل و آنوا با استفاده از نرم افزار اس پی اس اس نسخه 18 تجزیه و تحلیل شدند (α≤0.05). یافتهها نشان داد شش هفته تمرین تناوبی خیلی شدید باعث کاهش غیرمعنادار BNP و ANP در گروه تجربی نسبت به گروه کنترل (به ترتیب 0.67=P و 0.475≥P) و کاهش معنادار آنها در طی شش هفته تمرین تناوبی با شدت پایین نسبت به گروه کنترل شد (به ترتیب 0.001=P و 0.011≥P). این کاهش در گروه تمرین تناوبی با شدت پایین به طور معناداری از گروه تمرین تناوبی خیلی شدید موثرتر بود. BNP( (p= 0.001و ANP( (p= 0.005. در کل ، هر دو شدت تمرینی باعث کاهش مقادیر هورمونهای قلبی نسبت به گروه بدون تمرین پس از آنفارکتوس میوکارد میشود.
https://spj.ssrc.ac.ir/article_1110_cf3d2bb3e06618fc61b6f6190065e3bc.pdf
2018-01-21
159
172
10.22089/spj.2017.4185.1561
آنفارکتوس میوکارد
هورمونهای قلبی
تمرین
رت
مهران
قهرمانی
mehrangilan@gmail.com
1
استادیار فیزیولوژی ورزشی، دانشگاه آزاد اسلامی، واحد گیلان غرب
AUTHOR
سارا
کربلایی فر
sk1980.karbalaei40@yahoo.com
2
دکترای فیزیولوژی ورزشی، دانشگاه تهران، پردیس بین الملل کیش
LEAD_AUTHOR
Nathalie M. Benda TM. Eijsvogels A P. Dijk M. Hopman TE. Dick H. J. Thijssen. Changes in BNP and cardiac troponinI after high-intensity interval and endurance exercise in heart failure patients and healthy controls. Int J Cardiol. 2015: 1(184): 426–7.
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Vicky A. Miriam TC. Rademaker LJ. Ellmers A. Espiner M. Nicholls G. Richards M. Atrial(ANP) and Brain Natriuretic Peptide(BNP) Expression after Myocardial Infarction in Sheep: ANP Is Synthesized by Fibroblasts Infiltrating the Infarct. endocrinology society . 2000: 12(141): 4690-7.
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Sabatine MS. Morrow DA. de Lemos JA. Omland T. Desai MY. Tanasijevic M. Hall C. McCabe CH. Braunwald E. Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia. J Am Coll Cardiol. 2004: (16); 44(10): 1988-95.
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Kaplon B. Opolski G. Kosior D. Janion M. An increase in plasma atrial natriuretic peptide concentration during exercise predicts a successful cardioversion and maintenance of sinus rhythm in patients with chronic atrial fibrillation. Pacing Clin Electrophysiol. 2000: (23): 11. 1876-9.
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Thijs M. Eijsvogels H. Arie P. J. Van Dijk. Maria T. E. Hopman Dick H. J. Thijssen. Nathalie M. Benda M. Changes in BNP and cardiac troponin I after high-intensity interval and endurance exercise in heart failure patients and healthy controls. International Journal of Cardiology. 2015: (184): 426–7.
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Ravasi AA, Kordi MR, Naghizade S, Kazemi F. [The Effect of a session of endourance and sprint exercises on plasma ANP in Male Athlete Students (Persian)]. Tehran: Olome zisti varzesh. 2011; 4(14): 125-38.
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Khalighfard S, Gaeini A, Nazarali P. [The Effect of Endurance Exercise on Cardiac Stress and Exercise Induced Immune Response in Elite Kayakers(Persian)]. RJMS. 2011; 17(80 and 81): 8-15.
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Guazzi M, Vitelli A, Arena R. The effect of exercise training on plasma NT-pro-BNP levels and its correlation with improved exercise ventilatory efficiency in patients with heart failure. 2012; 2(158): 290–9.
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Morten A. Hoydal MA. Wisloff U. Kemi OJ. Ellingsen O. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. Eur J Cardiovasc Prev Rehabil. 2007; Dec; 14(6): 753-60.
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Wisloff U. Helgerud J. Kemi OJ. Ellingsen O. Intensity-controlled treadmill running in rats: VO2 max and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2000; Mar; 280(3): 301-10.
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Kraljevic J. Marinovic J. Pravdic D. Zubin P. Dujic Z. Wisloff U. Ljubkovic M. Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart. Cardiovasc Res. 2013: 1; 99(1): 55-64.
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Kemi OJ. Haram PM. Loennechen JP. Osnes JB. Skomedal T. Wisløff U. Ellingsen O. Moderate vs high exercise intensity: Differential effects on aerobic fitness. cardiomyocyte contractility. and endothelial function. Cardiovasc Res 2005: 67(1): 161-72.
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Borer K A. exercise endocrinology. Gaeini AA. Koshki jahromi M. Hamidiniya MR. 2thed. Tehran: samt; 2013. 204-41.
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Ma KK. Ogawa T. De Bold AJ. Selective up regulation of cardiac brain natriuretic peptide at the transcriptional and translational levels by proinflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via p38 MAP kinase. J Mol Cell Cardiol. 2004: (36): 505–13.
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Conraads V. Beckers P. Vaes J. Martin M. Van Hoof V. De Maeyer C et al. Combined endurance/resistance training reduces NT-proBNP levels in patients with chronic heart failure. Eur Heart J. 2004: (25): 1797-805.
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ORIGINAL_ARTICLE
اثرات فعالیت ورزشی هوازی و محدودیت کالری (رژیم غذایی کم کربوهیدرات و رژیم غذایی استاندارد) بر آدیپوکاینهای مؤثر بر مقاومت انسولین در موش صحرایی نر دیابتی نوع دو
هدف از مطالعهی حاضر، بررسی تاًثیر تعاملی محدودیت کالری (رژیم غذایی استاندارد و رژیم غذایی کم کربوهیدرات) و در ترکیب با فعالیت ورزشی هوازی بر میزان آدیپوکاینهای مؤثر بر مقاومت انسولین در موش صحرایی نر دیابت نوع دو بود. در یک مطالعه تجربی، 48 سر موش صحرایی نر (سن 10هفته) نژاد ویستار (وزن 5/19±229 گرم) پس از دیابتی شدن به طور تصادفی به شش گروه: کنترل، فعالیت ورزشی هوازی (20% تعادل منفی انرژی)، 20% محدودیت کالری با رژیم غذایی استاندارد، 20% محدودیت کالری با رژیم غذایی کم کربوهیدرات، 20% محدودیت کالری با رژیم غذایی استاندارد ترکیب با فعالیت ورزش هوازی و 20% محدودیت کالری با رژیم غذایی کم کربوهیدرات ترکیب با ورزشی هوازی تقسیم شدند. سپس 20% تعادل منفی انرژی به صورت روزانه و به مدت 8 هفته برای تمام گروهها اجرا شد. یافتهها نشان داد فعالیت ورزشی هوازی به تنهایی و در ترکیب با رژیم غذایی کم کربوهیدرات باعث افزایش معنیداری در میزان امنتین-1 نسبت به گروه کنترل دیابتی شد (P≤0.05)، اما تفاوت معنیداری بین گروههای تجربی با گروه کنترل دیابتی در میزان کمرین مشاهده نشد. همچنین نتایج نشان داد گروه رژیم غذایی (استاندارد و کم کربوهیدرات) به تنهایی و در ترکیب با فعالیت ورزشی باعث کاهش معنیداری در میزان مقاومت انسولین شد (P≤0.05). این مطالعه نشان داد که روش ترکیبی فعالیت ورزشی هوازی و رژیم غذایی کم کربوهیدرات میتواند باعث افزایش امنتین-1 و بهبود حساسیت انسولین در موش صحرایی نر مبتلا به بیماری دیابت نوع دو شود.
https://spj.ssrc.ac.ir/article_1111_dd3ad8c7c19c55b27dfe84543847aa9b.pdf
2018-01-21
173
188
10.22089/spj.2017.4283.1572
امنتین-1
کمرین
مقاومت به انسولین
فعالیت ورزشی
رژیم غذایی
محدودیت کالری
حسین
دست بر حق
hosein.dast@yahoo.com
1
دانشجوی دکتری بیوشیمی و متابولیسم ورزشی، دانشگاه اصفهان
AUTHOR
مهدی
کارگرفرد
kargar_m46@yahoo.com
2
استاد فیزیولوژی ورزشی، دانشگاه اصفهان
LEAD_AUTHOR
عفت
بمبئی چی
e.bambaeichi@yahoo.com
3
دانشیار فیزیولوژی ورزشی، دانشگاه اصفهان
AUTHOR
حسن علی
عابدی
hassanaliabedi@jums.ac.ir
4
استادیار فیزیولوژی پزشکی، دانشگاه علوم پزشکی جهرم
AUTHOR
Lizcano F, Guzmán G. Estrogen deficiency and the origin of obesity during menopause. BioMed research international. Volume 2014, Article ID 757461, 11 pages.
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