Document Type : Research Paper
Authors
1 Department of Biological Sciences in Sports, Faculty of Sports and Health Sciences, Shahid Beheshti University, Tehran, Iran
2 faculty of sport science, shiraz university
Abstract
Objectives: The purpose of this study was to compare the effect of 4 weeks of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the angiogenesis pathway in nerve cells around the stroke infarct area.
Materials and methods: 32 adult male NMRI mice (age 8 weeks, weight 35 ± 1 g) were selected and randomly divided into 4 groups of 8 including sham, stroke, stroke + HIIT, and stroke + MICT groups. The training protocols were implemented for 4 weeks and 5 sessions per week, where the HIIT group performed an average of 7 bouts of 2 minutes (high intensity 95% Vmax and low intensity 45% Vmax) and the MICT group with an average intensity of 60% Vmax for 55 minutes. 48 hours after the last training session, a stroke was induced by the (t-d MCAO) method, and after 24 and 48 hours, neurological deficits, behavioral tests, and penumbra area biopsy were performed.
Results: The results of the one-way analysis of variance statistical test showed a significant difference in the changes of VEGF-R2, HIF-1α, Ang-2, FGF-2 and STAT3 between groups, and these changes were in the HIIT exercise group compared to the MICT group and Other groups were significant (P<0.05), while the VEGF values in the MICT group increased significantly compared to other groups (P<0.05).
Conclusion: The findings of the present study show that a period of 4 weeks of preconditioning high-intensity interval training can be considered as a suitable strategy for the prevention and treatment of stroke.
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