Document Type : Research Paper

Authors

1 Faculty of Physical Education Razi University

2 Kermanshah University of medical Sciences - School of Medicine

Abstract

Abstract
The purpose of this study was to investigate the effects of regular aerobic training for 8 weeks on migraine headache indices and levels of nitric oxide in women with migraine. In this study, 29 women with common (without aura) migraine in the age range of 25 to 50 years were randomly divided into control group (n = 14) and experimental (n = 15) were studied. The performed aerobic exercise further experimental drug treatments similar to the control group, 8-week aerobic exercise program included 3 sessions per week with pre-determined duration and intensity (Borg’s Rate of Perceived Exertion scale (RPE scale, 6-20)). Migraine status, including the headache indicators (frequency, severity and duration), was assessed through the use of daily diaries (with visual analog scale (VAS)) regarding migraine. Fasting blood samples were taken before and after the intervention for measuring blood nitric-oxide levels in subjects. Data were analyzed by Kolmogrov-Smirnov, the independent and paired T-test at significance level of α ≤0.05. performing aerobic exercise for 8 weeks caused significant increase in blood nitric oxide levels and significant decrease in migraine headache indices (frequency, intensity and duration of headache) in the exercise group (p<0.001). In the control group, no significant changes were observed for the mentioned variables. It appears that aerobic exercise as a complementary therapy in conjunction with other treatments in patients with migraine headaches and Reduce symptoms maintained.

Keywords

Main Subjects

1) Alexandrea J. Managing migraines. Diabetes Forecast.1998; 51, 23.
2) Bartleson JD. Treatment of migraine headache. Mayo Clin Proc Jan. 1999; 1–5.
3) Pate RR, Pratt M, Mlair SN, et al. Physical activity and public health. A recommendation from the Centers for Disease Control and prevention and the American College of Sports Medicine. JAMA. 1995; 273, 402-7.
4) Akbayark T, Citak I, Demterturkan F& Akarcal I. Manual therapy and pain change in patients with migraine - an open pilot Study. Advances in Physiotherapy. 2001; 3: 49-54.
5) Kaufman, D. M. Clinical neurology for psychiatrists (4th. ed). New York: W. D. Saunders Company. 1995.
6) Brandes JL. The migraine cycle: patient burden of migraine during and between migraine attacks. Headache. 2008; 48(3): 430-41.
7) Burton WN, Landy SH, Dowans KE, Runken CM. The impact of migraine and effect of migraine treatment on workplace productivity in the United Statea and suggestions for future research. Mayo Clin Proc. 2009; 84(5): 436-45.
8) Vlajinac Hristina, Sipetic Sandra, Dzoljic Eleonora, Maksimovic Jadranka, Marinkovic Jelena, Kostic Vlada. same lifestyle habite of female Belgrade university student with migraine and non- migraine primarry headache. Headache Pain. 2003. 67-71.
9) Narin SO, Pinar L , Erbas D , Oztürk V, Idiman F. The effects of exercise and exercise-related changes in blood nitric oxide level on migraine headache. Clinical Rehabilitation. 2003; 17, 624–30.
10) Busch V, Gaul CH. Exercise in Miigraine Therapy- Is There Any Evidence for Efficacy? An aura pathophysiology: the role of blood vessels and microembolisation Critical Review. Compilation, 2008; 48: 890-9.
11) Varkey E, Cider A, Carlsson J, Linde M. A study to evaluate the feasibility of an aerobic Exercise program in patients with migraine. Headache. 2009; 49, 563-570
12) Jungersten L, Ambring A, Wall B, Wennmalm A. Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. J Appl Physiol , 1997; 82:    760-4.
13) Lin Long-ni. Overview of migraine. J of neuroscience nurs. 2001; 33(1) : 6-12
14) William B, Silberstein A. Migraine and other headaches. Massachusetts: Harvard Medical School . 2001.
15) Bode-Boger SM, Boger RH, Schroder EP, Frolich JC. Exercise increases systemic nitric oxide production in men. J Cardiovasc Risk , 1994; 1: 173-8.
16) Kelman L. The triggers or precipitants of the acute migraine attack. Cephalalgia ,2007; 27, 394-402.
17) Raskin NH. Headache In: Rowland LP. Merritt’s textbook of neurology: From Lippincott Williams & Wilkins. Philadelphia. 2000 ;12-807, 8-36.
18) Ashina M, Lassen LH, Bendtsen L, Jensen R, Olesen J. Effect of inhibition of nitric oxide synthase on chronic tension type headache: a randomized crossover trial. Lancet .1999; 353: 256-7.
19) Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders. Cephalalgia; 2004. 24(suppl 1):1:160.
20) Kelly AM . The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain. Emerge Med J; 2001; 18(3): 205-7.
21) Calhoun AH, Ford S. Behavioral sleep modification may revert transformed migraine to episodic migraine. Headache; 2007; 47:1178-83.
22) Dittric MS, Verena G, Gerhard F, Martin B, Bernhard H, Martin K. Aerobic exercise with relaxation: Influence on pain and psychology well-being in female migraine patients. Clin J Sport Med. 2008; 18(4):363-5.
23) Medicinenet.com [homepage on the Internet]. New York: Medical Association; 1996-2010 [updated 2010 Jun 9; cited 2005 Nov 5]. Progressive muscle relaxation for stress and insomnia. Available from: http://www.medicinenet.com
24) Neususs K, Neumann B, Steinhoff BJ, Thegeder H, Bauer A, Reimers D. Physical activity and fitness in patients with headache disorders. J Sports Med. Nov. 1997; 18(8):607–11.
25) Grimm L, Douglas D, Hanson P. Aerobic training in the prophylaxis of migraine. Med Sci Sports exercise. 1981; 13: 98.
26) Koseoglu E, Akboyraz A, Soyuer A and Ersoy AO. Aerobic exercise and plasma beta endorphin levels in patients with migrainous headache without aura. Cephalalgia; 2003. 23(10): 972–6.
27) Gerber W, Miltner W, Gabler H, Hildebrand E, Larbig W. Bewegungs- und Sporttherapia bei chronischen Kopfschmerzen. In EDS. Vorgebnisse und Perspektiven interdisziplinarer Forschung. Weinheim: edition medizin: 1987; 55-66.
28) Fitterling JM, Martin JE, Gramling S, Cole P, Milan MA, Behavioral management of exercise training in vascular headache patients: An investigation of exercise adherence and headache activity. J APPL Behav Anal, 1988. 21, 9-19.
29) Nordlander E, Cider A, Carlsson J, Linde M. Improvement of exercise capacity in patients with migraine - Methodological considerations. Cephalalgia. 2007; 27: 575-759.
30) Lockett DM, Campbell JF. The Effects of aerobic exercise on migraine. Headache. 1992; 32: 50-4.
31) Gudmudsson LS, Scher AL. Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study. British medical journal. 2010; 341(c3966): 524-8
32) Darling M. The use of exercise as a method of aborting migraine. Headache. 1991; 31: 616-8.
33) Mououdi MA, Choobineh AR. Ergonomics in practice: selected ergonomics topics. Tehran: Nashr-e-Markaz. 1999; 81-94.
34) Seiji M, Takashi M, Tetsuji K, Jun S, Motoyuki I, Yoko IT and et.al . Effects of exercise training of 8 weeks and detraininig on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans. Elsevier Science Inc. 2001; 69 : 1005-16.
35) Sarchielli P, Alberti A, Codini M, Floridi A, Gallai V. Nitric oxid pathway, Ca2+, and serotonin content in platelets from patients suffering from chronic daily headache. Cephalalgia; 2000. 19: 160–810.
36) Varin R, Mulder P, Richard V, Tamion F. Exercise improves flow-mediated vasodilatation of skeletal muscle arteries in rats with chronic heart failure: role of nitric oxide, prostanoids and oxidant stress. Circulation. 1999; 99, 2951-7.
37) McCrory P. Recognizing exercise-related headache. Physician Sportsmed; 1997.      33–9.
38) Lehane E, McCarthy G. An examination of the intentional and unintentional aspects of medication non-adherence in patients diagnosed with hypertension. J Clin Nurs. 2007;4(16): 698-706.
 
 
39) Ulfarson J, Bardage C. Adherence to drug treatment in association with how the patient perceives care and information on drug. J Clin Nurs. 2007; 2(16):141-8.