Sport Sciences Research Institute Sport Physiology 2322-164X 10 37 2018 04 21 Effect of High Intensity Interval Training on miR-1, miR133-a Gene Expression in Rats with Myocardial Infarction Effect of High Intensity Interval Training on miR-1, miR133-a Gene Expression in Rats with Myocardial Infarction 87 98 1151 10.22089/spj.2018.1151 FA Pedram Ghorbani Ph.D. Student of Sport Physiology, University of Tehran, Kish International Campus Mohammad Reza Kordi Associate Professor of Sport Physiology, University of Tehran 0000-0002-7999-4292 Abbasali Gaeini Professor of Sport Physiology, University of Tehran Reza Noori Assistant Professor of Sport Physiology, University of Tehran, Kish International Campus 0000-0003-1976-3561 Sara Karbalaeifar Ph.D. Student of Sport Physiology, University of Tehran, Kish International Campus Journal Article 2016 06 16 The aim of this study was to investigate the effect of intensive interval training on ‌‌miR-1, miR133-a gene expression in rats with myocardial infraction. For this purpose, 12 Wistar male rats with 10 weeks old and average weight 250-300gr that infected to Myocardial infarction and they were designed in to two groups of experimental (60 minutes of interval running on treadmills that each interval is 4 minutes of running with the 85-90 percent of Vo2max and 2 minutes of active rest at 50-60 percent of Vo2max for four days in a week and 6 weeks) and control group (without any training). Genes expression was investigated by the PCR technique and data were analyzed by the SPSS 18 with T test (α≤0.05). The findings of present study showed that the levels of miR-1 in high intensity interval training (4.33mg.ml-1) significantly much more than the control group (3.541mg.ml-1)(P=0.012) and the amount of miR-133a in high intensity interval training group (4.876 mg.ml-1) was also much more than control group (1.01mg.ml-1)(P≤0.001) . in general, 6 weeks of high intensity interval training with intensity of 50-60 percent of Vo2max leads to increased expression of miR-1 and miR-133a in male Vistar rats with MI. The aim of this study was to investigate the effect of intensive interval training on ‌‌miR-1, miR133-a gene expression in rats with myocardial infraction. For this purpose, 12 Wistar male rats with 10 weeks old and average weight 250-300gr that infected to Myocardial infarction and they were designed in to two groups of experimental (60 minutes of interval running on treadmills that each interval is 4 minutes of running with the 85-90 percent of Vo2max and 2 minutes of active rest at 50-60 percent of Vo2max for four days in a week and 6 weeks) and control group (without any training). Genes expression was investigated by the PCR technique and data were analyzed by the SPSS 18 with T test (α≤0.05). The findings of present study showed that the levels of miR-1 in high intensity interval training (4.33mg.ml-1) significantly much more than the control group (3.541mg.ml-1)(P=0.012) and the amount of miR-133a in high intensity interval training group (4.876 mg.ml-1) was also much more than control group (1.01mg.ml-1)(P≤0.001) . in general, 6 weeks of high intensity interval training with intensity of 50-60 percent of Vo2max leads to increased expression of miR-1 and miR-133a in male Vistar rats with MI. https://spj.ssrc.ac.ir/article_1151_f197002b9a0853eca5e046d9ca4663d5.pdf