Sport Sciences Research Institute Sport Physiology 2322-164X 12 45 2020 03 20 Muscle Murf1 and P70S6K Before and After 6 Weeks of Resistance Training and HMB Supplementation in Inactive Men Muscle Murf1 and P70S6K Before and After 6 Weeks of Resistance Training and HMB Supplementation in Inactive Men 79 94 1621 10.22089/spj.2018.5770.1761 FA Seyed Mostafa Mousavi Mozafar Ph.D. Student of Exercise Physiology, Shahid Beheshti University, Tehran Maryam Nourshahi Associate Professor of Exercise Physiology, Shahid Beheshti University, Tehran 0000-0002-5064-8599 Ali Akbarnejad Associate Professor of Exercise Physiology, University of Tehran Journal Article 2018 07 02 Resistance training with HMB supplement helps preserving the body mass and, that is why, it is extensively practiced by athletes. However, there are contradictory results about the effect of the pathway of this supplement on increasing factors related to hypertrophy or reduction of atrophy. The present study investigates the effect of HMB and resistance training on response to Muscle MuRF1 and P70S6K in inactive men. To this end, 40 inactive men with the average age (25.5±5 years) and a BMI of (21.2±2 kg/m2) were divided into the following four training categories: training, training+HMB, HMB and control. The subjects did bodybuilding exercises (3set/10-12repitations/75%-80%1RM) for four days a week over a six-week time period. The control group did not do any kinds of exercise. The vastus lateralis muscle biopsy and 1RM amounts of each subject in leg press movement were conducted and measured before and after six weeks of training and consuming the supplement. The results of one-way ANOVA and repeated variance analysis test with inter-group factor showed that there is a difference (P= 0.001) between the increase of 1RM before and after six weeks of training and the amounts of P70S6K (P= 0.001) in all three groups in comparison with the control group. However, this difference was not significant (P= 0.22) in MuRF1 amounts. As a result, consuming HMB supplement in the course of training can lead to the increase of P70S6K response as a marker of hypertrophy and an increase of strength in the leg press after six weeks. Resistance training with HMB supplement helps preserving the body mass and, that is why, it is extensively practiced by athletes. However, there are contradictory results about the effect of the pathway of this supplement on increasing factors related to hypertrophy or reduction of atrophy. The present study investigates the effect of HMB and resistance training on response to Muscle MuRF1 and P70S6K in inactive men. To this end, 40 inactive men with the average age (25.5±5 years) and a BMI of (21.2±2 kg/m2) were divided into the following four training categories: training, training+HMB, HMB and control. The subjects did bodybuilding exercises (3set/10-12repitations/75%-80%1RM) for four days a week over a six-week time period. The control group did not do any kinds of exercise. The vastus lateralis muscle biopsy and 1RM amounts of each subject in leg press movement were conducted and measured before and after six weeks of training and consuming the supplement. The results of one-way ANOVA and repeated variance analysis test with inter-group factor showed that there is a difference (P= 0.001) between the increase of 1RM before and after six weeks of training and the amounts of P70S6K (P= 0.001) in all three groups in comparison with the control group. However, this difference was not significant (P= 0.22) in MuRF1 amounts. As a result, consuming HMB supplement in the course of training can lead to the increase of P70S6K response as a marker of hypertrophy and an increase of strength in the leg press after six weeks. https://spj.ssrc.ac.ir/article_1621_4462bf0ddbe0d0da40e1e828ebebeb11.pdf