Sport Sciences Research Institute Sport Physiology 2322-164X 11 42 2019 07 23 Effect of 6 Weeks High Intensity Interval Training on Selected Factors of Cardiac Angiogenesis in Rats with Myocardial Infarction Effect of 6 Weeks High Intensity Interval Training on Selected Factors of Cardiac Angiogenesis in Rats with Myocardial Infarction 17 30 1732 10.22089/spj.2019.2676.1359 FA Sara Karbalaeifar Ph.D. Student of Exercise Physiology, Tehran University, Kish International Campus, Kish, Iran Abbas Ali Gaeini Professor of Exercise Physiology, Tehran University, Tehran, Iran Mohammad Reza Kordi Associate Professor of Exercise Physiology, Tehran University, Tehran, Iran 0000-0002-7999-4292 Reza Nuri Assistant Professor of Exercise Physiology, Tehran University, Kish International Campus, Kish, Iran 0000-0003-1976-3561 Pedram Ghorbani Ph.D. Student of Exercise Physiology, Tehran University, Kish International Campus, Kish, Iran Journal Article 2016 06 17 Myocardial infarction (MI) is cell death in part of the myocardial during an Ischemia. Cell process in response to activity and appropriate intensity is not clear yet. Therefore, this research done to evaluate the effect of 6 weeks high intensity interval training (HIIT) on expression of VEGF, COL-18 and their common receptor (Flt-1) genes. For this purpose, 12 Wistar male rats with 10 weeks old and average weight 250-300 gr that infected to myocardial infarction and they were designed in to two groups of experimental (60 minutes of interval running on treadmills that each interval is 4 minutes with the 85-90 percent of Vo2max and 2 minutes of active rest at 50-60 percent of Vo2max for four days in a week and during a period of 6 weeks) and control group (without any training) . Genes expression was investigated by the PCR technique and data were analyzed by the SPSS 18 with T test (α≤0.05). The findings of present study showed that the amount of VEGF in HIIT (6.397 mg/ml) is significantly much more than the control group (1.002 mg/ml) (P=0.001) and the amount of Flt-1 in HIIT group (8.927 mg/ml) was also significantly much more than control group (1.380 mg/ml) (P≤0.001) . and the amount of COL-18 in HIIT group (1.724 mg/ml) was not significantly more than control group (1.265 mg/ml) (P≤0.340). In general, 6 weeks of HIIT can effective on angiogenesis factors after MI in male Wistar rats. Myocardial infarction (MI) is cell death in part of the myocardial during an Ischemia. Cell process in response to activity and appropriate intensity is not clear yet. Therefore, this research done to evaluate the effect of 6 weeks high intensity interval training (HIIT) on expression of VEGF, COL-18 and their common receptor (Flt-1) genes. For this purpose, 12 Wistar male rats with 10 weeks old and average weight 250-300 gr that infected to myocardial infarction and they were designed in to two groups of experimental (60 minutes of interval running on treadmills that each interval is 4 minutes with the 85-90 percent of Vo2max and 2 minutes of active rest at 50-60 percent of Vo2max for four days in a week and during a period of 6 weeks) and control group (without any training) . Genes expression was investigated by the PCR technique and data were analyzed by the SPSS 18 with T test (α≤0.05). The findings of present study showed that the amount of VEGF in HIIT (6.397 mg/ml) is significantly much more than the control group (1.002 mg/ml) (P=0.001) and the amount of Flt-1 in HIIT group (8.927 mg/ml) was also significantly much more than control group (1.380 mg/ml) (P≤0.001) . and the amount of COL-18 in HIIT group (1.724 mg/ml) was not significantly more than control group (1.265 mg/ml) (P≤0.340). In general, 6 weeks of HIIT can effective on angiogenesis factors after MI in male Wistar rats. https://spj.ssrc.ac.ir/article_1732_270edd69788dce200a3b395a6da6fdb7.pdf