Sport Sciences Research Institute Sport Physiology 2322-164X 14 55 2022 11 22 The comparison effects of a period of high intensity interval training and continues training on SIRT3 and antioxidant defense system of gastrocnemius muscle in female aged rats The comparison effects of a period of high intensity interval training and continues training on SIRT3 and antioxidant defense system of gastrocnemius muscle in female aged rats 49 70 2206 10.22089/spj.2020.9044.2040 FA Ali Askarian Department of exercise physiology, Faculty of sport sciences, University of Tehran, Tehran, Iran 0000-0003-3850-811x Abbas Ali Gaeini Professor 0000-0002-8679-0669 Mohammad Reza Kordi Department of exercise physiology, faculty of sport sciences, University of Tehran, Tehran Iran 0000-0002-7999-4292 Siroos Choobine Department of Exercise physiology, faculty of health sciences, University of Tehran, Tehran, Iran 0000-0003-4466-0986 Journal Article 2020 06 07 the aim of this study was to comparison of 12 weeks of high intensity interval training and continues training on SIRT3 and superoxide dismutase (SOD) activity in gastrocnemius muscle of aged female Wistar rats. Methods: 15 female Wistar rats (age= 18 month, weight= 270-350 g) were chosen and divided into 3 groups; high intensity interval training (HIIT), Continues training (CT), and Control. After determining rat’s VO2max, progressive HIIT and CT protocols were designed with the intensity corresponds to 85-90% VO2max and 65-70 % VO2max, respectively and training duration in HIIT was approximately half of CT. 48 hours after the last training session, rats were sacrificed and their gastrocnemius muscle samples were saved for further analysis. Results: This study showed a significant difference of SIRT3 between HIIT, CT, and control group (p=0.001) (Control the aim of this study was to comparison of 12 weeks of high intensity interval training and continues training on SIRT3 and superoxide dismutase (SOD) activity in gastrocnemius muscle of aged female Wistar rats. Methods: 15 female Wistar rats (age= 18 month, weight= 270-350 g) were chosen and divided into 3 groups; high intensity interval training (HIIT), Continues training (CT), and Control. After determining rat’s VO2max, progressive HIIT and CT protocols were designed with the intensity corresponds to 85-90% VO2max and 65-70 % VO2max, respectively and training duration in HIIT was approximately half of CT. 48 hours after the last training session, rats were sacrificed and their gastrocnemius muscle samples were saved for further analysis. Results: This study showed a significant difference of SIRT3 between HIIT, CT, and control group (p=0.001) (Control https://spj.ssrc.ac.ir/article_2206_fea9c11c4ad9a395a636ed944a28b51a.pdf