Sport Sciences Research Institute Sport Physiology 2322-164X 7 28 2016 02 20 Profile of physiological, anthropometric, biomotor and psychological characteristics in Futsal for men Profile of physiological, anthropometric, biomotor and psychological characteristics in Futsal for men 15 30 583 FA Journal Article 2015 03 04 The aim of this study was to determine the profile of physiological, anthropometric, biomotor and psychological characteristics of Iran’s elite Futsal players in two age groups (youth and adults). So 23 national team youth players (mean age 21.73±1.09 yr, weight 71.33±7.60 kg, height 174.23±5.64 cm) and 21 national team adult players (mean age 26.90±3.03 yr, weight 76.32±4.29 kg, height 177.21±3.87 cm) attended in national team’s camp, were chosen. Body composition (weight, fat percent, BMI), physiological (nonaerobic power (Rast test), aerobic power (respiratory gases analyzing system)), anthropometric (ambience and length of femur, ambience and length of shank, height, seated height, lower limb length), biomotor (flexibility (sit and reach test), speed (36 m), agility (Illinois test), leg’s explosive power (Sargent test)) and psychological characteristics (motivation, self confidence, concentration, mental imagery, controlling psychological level, goal setting (using SASI Psych questionnaire)) was measured. Analyzing the study's finding by using descriptive and independent T test showed that there are no significant differences between the average of measured characteristics in two age groups unless in weight (P=0.01), ambience of shank (P=0.000) and fat percent (P=0.01) characteristics, that adults had higher quantity. The findings of the study showd that the requirements of Futsal in investigated characteristics between youth and adults were similar and only adults are a little heavier because of more fat and non fat mass (P<0.05). The aim of this study was to determine the profile of physiological, anthropometric, biomotor and psychological characteristics of Iran’s elite Futsal players in two age groups (youth and adults). So 23 national team youth players (mean age 21.73±1.09 yr, weight 71.33±7.60 kg, height 174.23±5.64 cm) and 21 national team adult players (mean age 26.90±3.03 yr, weight 76.32±4.29 kg, height 177.21±3.87 cm) attended in national team’s camp, were chosen. Body composition (weight, fat percent, BMI), physiological (nonaerobic power (Rast test), aerobic power (respiratory gases analyzing system)), anthropometric (ambience and length of femur, ambience and length of shank, height, seated height, lower limb length), biomotor (flexibility (sit and reach test), speed (36 m), agility (Illinois test), leg’s explosive power (Sargent test)) and psychological characteristics (motivation, self confidence, concentration, mental imagery, controlling psychological level, goal setting (using SASI Psych questionnaire)) was measured. Analyzing the study's finding by using descriptive and independent T test showed that there are no significant differences between the average of measured characteristics in two age groups unless in weight (P=0.01), ambience of shank (P=0.000) and fat percent (P=0.01) characteristics, that adults had higher quantity. The findings of the study showd that the requirements of Futsal in investigated characteristics between youth and adults were similar and only adults are a little heavier because of more fat and non fat mass (P<0.05).

https://spj.ssrc.ac.ir/article_583_9ad6aaed513b73148b7d49f70afcfb32.pdf

Sport Sciences Research Institute Sport Physiology 2322-164X 7 28 2016 02 20 Comparison the maximal fat oxidation and Fatmax in trained and untrained women Comparison the maximal fat oxidation and Fatmax in trained and untrained women 31 44 594 FA Hadi Rohani Assistant Professor in Exercise Physiology, Sport Sciences Research Institute of Iran, Tehran, Iran 0000-0002-0437-753X Seyed Saleh Safari Mousavi PhD Student in Exercise Physiology, University of Guilan, Rasht, Iran Samira Gholamian PhD Student in Exercise Physiology, Ferdowsi University, Mashhad, Iran; Lab Technician, Sport Sciences Research Institute of Iran, Tehran, Iran Esmaeil Farzaneh Researcher (MSc) in Exercise Physiology, Sport Sciences Research Institute of Iran, Tehran, Iran Journal Article 2015 08 01 The aim of current study was comparison the maximal fat oxidation and the exercise intensity elicit maximal fat oxidation (Fatmax) between trained and untrained girls. 10 healthy untrained (exercising <3h/week; VO2max, 2.66±0.34 l/min) and 10 healthy trained (basketball players in provincial league; VO2max, 2.83±0.29 l/min) girls, 20-25 years old and normal weight, were selected. All subjects performed an incremental exercise test with 3-min stages to exhaustion on a stationary bike after 10-12 h night fasting. Respiratory gases were measured using an open-circuit gas analyzer system during the test and, substrate oxidation rate, maximal fat oxidation and Fatmax were calculated using stoichiometric equations. ANOVA with repeated measures and independent t-test were used for comparing the variables at p<0.05 level. The mean of MFO and Fatmax were significantly higher in trained in compare to untrained subjects (P<0.05). In compare to untrained, fat oxidation rate was significantly higher in trained subjects at the intensities >55% VO2max (P<0.05). Generally, higher level of fitness status in trained people can improve fat oxidation and reduce carbohydrate oxidation during exercise and then, reduction of fat oxidation can begin at higher intensity; so they depend on carbohydrate sources, later. The aim of current study was comparison the maximal fat oxidation and the exercise intensity elicit maximal fat oxidation (Fatmax) between trained and untrained girls. 10 healthy untrained (exercising <3h/week; VO2max, 2.66±0.34 l/min) and 10 healthy trained (basketball players in provincial league; VO2max, 2.83±0.29 l/min) girls, 20-25 years old and normal weight, were selected. All subjects performed an incremental exercise test with 3-min stages to exhaustion on a stationary bike after 10-12 h night fasting. Respiratory gases were measured using an open-circuit gas analyzer system during the test and, substrate oxidation rate, maximal fat oxidation and Fatmax were calculated using stoichiometric equations. ANOVA with repeated measures and independent t-test were used for comparing the variables at p<0.05 level. The mean of MFO and Fatmax were significantly higher in trained in compare to untrained subjects (P<0.05). In compare to untrained, fat oxidation rate was significantly higher in trained subjects at the intensities >55% VO2max (P<0.05). Generally, higher level of fitness status in trained people can improve fat oxidation and reduce carbohydrate oxidation during exercise and then, reduction of fat oxidation can begin at higher intensity; so they depend on carbohydrate sources, later.

https://spj.ssrc.ac.ir/article_594_076a0c97d09cf1a0ec3e19c7f2529f2b.pdf

Sport Sciences Research Institute Sport Physiology 2322-164X 7 28 2016 02 20 Effects of Eight Weeks Aerobic Training on Serum Apo A-I ,APO B and lipid profile in Overweight Women Effects of Eight Weeks Aerobic Training on Serum Apo A-I ,APO B and lipid profile in Overweight Women 45 58 586 FA Zahra Sarlak Journal Article 2014 08 18 The aim of this study was evaluation the Effects of eight Weeks Aerobic Training on Serum apo A-I, apo B and lipid profile in inactive Overweight Women. Statistics population of this semi-experimental study were 20-30 years old women with BMI>25 kg/m2 that selected by purposeful-available sampling and were randomly divided into training (n = 11) and control group (n = 10). The training group followed eight weeks running aerobic exercise training, three sessions per week with 55-75% of maximum heart rate. Data were analyzed with independent t test. The results of this study showed that body fat percent, body mass index, cholesterol, triglyceride, high density lipoprotein and low density lipoprotein did not significantly change following 8 weeks aerobic training (P>0.05), but apo B sinificantly decreased (P =0.008) and apo A-1 sinificantly increased (P =0.042). the results of this study showed that although aerobic training had not a significant effect on weight, body fat percent and risk factors of cardiovascular disease, cause a significant improve in reverse transfer of cholesterol and these change positively prevent from atherosclerosis. This findings showed that as a result of exercise training apo A and B are more affected than LDL and HDL and then obviously show the effect of exercise training. The aim of this study was evaluation the Effects of eight Weeks Aerobic Training on Serum apo A-I, apo B and lipid profile in inactive Overweight Women. Statistics population of this semi-experimental study were 20-30 years old women with BMI>25 kg/m2 that selected by purposeful-available sampling and were randomly divided into training (n = 11) and control group (n = 10). The training group followed eight weeks running aerobic exercise training, three sessions per week with 55-75% of maximum heart rate. Data were analyzed with independent t test. The results of this study showed that body fat percent, body mass index, cholesterol, triglyceride, high density lipoprotein and low density lipoprotein did not significantly change following 8 weeks aerobic training (P>0.05), but apo B sinificantly decreased (P =0.008) and apo A-1 sinificantly increased (P =0.042). the results of this study showed that although aerobic training had not a significant effect on weight, body fat percent and risk factors of cardiovascular disease, cause a significant improve in reverse transfer of cholesterol and these change positively prevent from atherosclerosis. This findings showed that as a result of exercise training apo A and B are more affected than LDL and HDL and then obviously show the effect of exercise training.

https://spj.ssrc.ac.ir/article_586_605ff764c617d3cd28dbbdd72be8f9a2.pdf

Sport Sciences Research Institute Sport Physiology 2322-164X 7 28 2016 02 20 The effect of 14 weeks of endurance training on miR-499 expression of left ventricle in wistar male rat The effect of 14 weeks of endurance training on miR-499 expression of left ventricle in wistar male rat 59 72 587 FA Mohammad Fathi 0000-0002-2113-365X Saeed Abroun Journal Article 2014 09 01 The aim of this study was to investigate the effect of endurance training on cardiac expression of miR-499, For this purpose, 14 rats under controlled conditions (temperature, light/dark (12:12) cycle, with ad Libitum access to food and water) were housed and after familiarization with protocol they were randomly assigned into control and Experimental groups. The experimental group performed 14 weeks endurance exercise on motorized treadmill, and then 48 hours after the end of the last session were anesthetized and sacrificed. The heart was removed and then left ventricle was dissected. Real time RT-PCR method was used to determine of expression levels of miR-449 in left ventricle and the obtained data were evaluated using one sample t-test. The hypertrophy evaluation indices showed that the ratio of left ventricle to the body weight in experimental group (2.3±0.18) was significantly (P=0.05) higher in compare control group (2.049±0.12) and the ratio of left ventricle to body surface area in experimental group (0.168±0.008) were significantly (P=0.01) higher in compare with control group (0.153±0.006). Finally, the mean of miR-499 expression of left ventricle in experimental group was significantly (P=0.004) higher than control group. It seems miR-499 expression relate to endurance induce cardiac hypertrophy special in left ventricle. The aim of this study was to investigate the effect of endurance training on cardiac expression of miR-499, For this purpose, 14 rats under controlled conditions (temperature, light/dark (12:12) cycle, with ad Libitum access to food and water) were housed and after familiarization with protocol they were randomly assigned into control and Experimental groups. The experimental group performed 14 weeks endurance exercise on motorized treadmill, and then 48 hours after the end of the last session were anesthetized and sacrificed. The heart was removed and then left ventricle was dissected. Real time RT-PCR method was used to determine of expression levels of miR-449 in left ventricle and the obtained data were evaluated using one sample t-test. The hypertrophy evaluation indices showed that the ratio of left ventricle to the body weight in experimental group (2.3±0.18) was significantly (P=0.05) higher in compare control group (2.049±0.12) and the ratio of left ventricle to body surface area in experimental group (0.168±0.008) were significantly (P=0.01) higher in compare with control group (0.153±0.006). Finally, the mean of miR-499 expression of left ventricle in experimental group was significantly (P=0.004) higher than control group. It seems miR-499 expression relate to endurance induce cardiac hypertrophy special in left ventricle.

https://spj.ssrc.ac.ir/article_587_766ebcd59621e305170616ba3d3dac32.pdf

Sport Sciences Research Institute Sport Physiology 2322-164X 7 28 2016 02 20 The effect of glutamine supplementation and judo preparatory training on positive and negative acute phase proteins in young judoists. The effect of glutamine supplementation and judo preparatory training on positive and negative acute phase proteins in young judoists. 73 86 588 FA Fallah Rahmani urmia Asghar Tofighi urmia 0000-0003-3626-1782 Ghafour Ghafari urmia Journal Article 2014 09 08 The purpose of this study was to investigate the effects of glutamine supplementation and judo preparatory training on positive and negative acute phase proteins in young Judoists. Accordingly, in a Quasi-experimental, double-blinded study, 48 young Judo (age: 21.34±5.13 years, height: 173.54±3.7 cm, weight: 70.56±6.14 kg) were randomly and easily- accessible selected, and randomly divided into 4 groups (n=12 for each group): exercise-supplementation, exercise placebo, supplementation, and control. Subjects in the supplementation group and placebo (maltodextrin) in prior and post of each session consumed 0.1 g/kg Bw supplement or placebo in Combined with 300 ml of water. The exercise program comprised Judo fitness training for 14 days and 5 sessions per week. Resulting data were analyzed by dependent t-tests and two-way ANOVA test at 0.5alpha error levels (P<0.05). statistical test results indicated that not only reduction in Haptoglobin was influenced by the separate effects of supplements and exercise, but combined intervention on both exercise and supplements had a synergistic effect on the reducing the concentrations of this acute phase protein. In addition, the effect of exercise alone and exercise accompanied by glutamine led to significant increase in albumin level in the post-test compared to baseline. While the glutamine supplementation alone, only led to reduces serum haptoglobin levels. Serum CRP levels during exercise in study groups remained unchanged. In summary, research result show that two two-week judos preparatory training can cause mild and positive acute phase response, and two weeks Glutamine Supplementation Lead to increased protein synthesis and strengthens the immune system in young judoists. The purpose of this study was to investigate the effects of glutamine supplementation and judo preparatory training on positive and negative acute phase proteins in young Judoists. Accordingly, in a Quasi-experimental, double-blinded study, 48 young Judo (age: 21.34±5.13 years, height: 173.54±3.7 cm, weight: 70.56±6.14 kg) were randomly and easily- accessible selected, and randomly divided into 4 groups (n=12 for each group): exercise-supplementation, exercise placebo, supplementation, and control. Subjects in the supplementation group and placebo (maltodextrin) in prior and post of each session consumed 0.1 g/kg Bw supplement or placebo in Combined with 300 ml of water. The exercise program comprised Judo fitness training for 14 days and 5 sessions per week. Resulting data were analyzed by dependent t-tests and two-way ANOVA test at 0.5alpha error levels (P<0.05). statistical test results indicated that not only reduction in Haptoglobin was influenced by the separate effects of supplements and exercise, but combined intervention on both exercise and supplements had a synergistic effect on the reducing the concentrations of this acute phase protein. In addition, the effect of exercise alone and exercise accompanied by glutamine led to significant increase in albumin level in the post-test compared to baseline. While the glutamine supplementation alone, only led to reduces serum haptoglobin levels. Serum CRP levels during exercise in study groups remained unchanged. In summary, research result show that two two-week judos preparatory training can cause mild and positive acute phase response, and two weeks Glutamine Supplementation Lead to increased protein synthesis and strengthens the immune system in young judoists.

https://spj.ssrc.ac.ir/article_588_daca41214b39c5dc66674d09081940f0.pdf

Sport Sciences Research Institute Sport Physiology 2322-164X 7 28 2016 02 20 Comparison of an acute bout of concurrent exercise training in different intensities on tumor necrosis factor- α (TNFα ) and interlokin-6 (IL-6 ) in active men Comparison of an acute bout of concurrent exercise training in different intensities on tumor necrosis factor- α (TNFα ) and interlokin-6 (IL-6 ) in active men 87 102 589 FA Esmaeil Azimian Student Ruohollah Ranjbar Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Shahid Chamran University of Ahvaz Journal Article 2014 10 22 The aim of this study was to investigate the comparison of an acute bout of combined exercise training in different intensities on interlokin-6 and tumor necrosis factor-α in active men. Ten active men with mean age 20.3±1.15 years, body mass index 21.88±1.73 kg/m2, and Vo2max 48.93±3.03 ml/kg/min volunteered for this study. Participants performed combined (at first aerobic phase and then resistance phase) exercise in low, moderate, and high intensities while aerobic phase including of 300 kcal in 8, 9.6, and 11.2 km/hr and resistance phase was composed of 45, 65, and 85% of 1- repetition maximum in 6 movements. Blood samples were taken before, immediately after and 24 hours after exercise. There was no significant difference in main effect of sampling time (P>0.05), exercise intensity (P>0.05), and interaction effect of time×intensity (P>0.05) in interlokin-6, tumor necrosis factor-α, and glucose. The results of this study indicated that an acute bout of combined exercise does not affect interlokin-6 and tumor necrosis factor-α level in active men while energy expenditure during aerobic phase and workload during resistance phase is similar in different intensities. The aim of this study was to investigate the comparison of an acute bout of combined exercise training in different intensities on interlokin-6 and tumor necrosis factor-α in active men. Ten active men with mean age 20.3±1.15 years, body mass index 21.88±1.73 kg/m2, and Vo2max 48.93±3.03 ml/kg/min volunteered for this study. Participants performed combined (at first aerobic phase and then resistance phase) exercise in low, moderate, and high intensities while aerobic phase including of 300 kcal in 8, 9.6, and 11.2 km/hr and resistance phase was composed of 45, 65, and 85% of 1- repetition maximum in 6 movements. Blood samples were taken before, immediately after and 24 hours after exercise. There was no significant difference in main effect of sampling time (P>0.05), exercise intensity (P>0.05), and interaction effect of time×intensity (P>0.05) in interlokin-6, tumor necrosis factor-α, and glucose. The results of this study indicated that an acute bout of combined exercise does not affect interlokin-6 and tumor necrosis factor-α level in active men while energy expenditure during aerobic phase and workload during resistance phase is similar in different intensities.

https://spj.ssrc.ac.ir/article_589_30bb3825e8f631cc6075c0f87bb4978c.pdf

Sport Sciences Research Institute Sport Physiology 2322-164X 7 28 2016 02 20 Effects of different dosages of garlic on responses of the main determinants of hemorheology to acute endurance exercise Effects of different dosages of garlic on responses of the main determinants of hemorheology to acute endurance exercise 103 116 590 FA Sajad Ahmadizad 0000-0001-5859-3556 Saeed Alipoor Saeed Dabagh Nikoo Kheslat Hadi Ebrahimi Journal Article 2014 11 08 The aim of this study was to investigate the effects of consuming different dosages of garlic on responses of the main determinants of hemorheology to acute endurance exercise in. Fifteen healthy young men (mean ± SD; age 27.0 ± 8 years; weight 73.9 ± 6 kg and height 175.3 ± 4 cm) with at least 3 years’ experience of regular participation in running or martial had voluntarily participated in this study. Subjects took different dosages of garlic (500, 750 and 1000 mg) and starch (placebo), in four separate sessions in a form of capsul with one week between them. In each session, 4 hours after taking the capsul subjects performed 30 min of running on the treadmill. Before and 4 hours after taking the capsuls and immediately after exercise hemodynamic factors and blood samples were taken. Blood samples were analyzed for blood and plasma viscosity, fibrinogen, hematocrit, hemoglobin and red blood cells (RBC) count. Data were analyzed using the repeated measures of ANOVA with repeated measure. Data analysis revealed that garlic dosage had significant effect on the plasma viscosity and fibrinogen (p=0.001). Paired comparisons showed that decreases in these two factors were significantly higher in 500 mg dosage than the two other. However, dosage of garlic did not have any significant effect on the responses of blood viscosity, hematocrit, hemoglobin and red blood cells (P=0.067). Regardless of the dosage, consuming the garlic supplement acutly 4 hours before exercise resulted in reduction in resting level of hemorheological variables (P=0.000). In addition, consuming garlic and its dosage did not have any significant effect on responses hemorheological variables to endurance exercise (P=0.59). Based on the findings of the present study, it could be concluded that consuming the garlic supplement had improved all hemorheological factors, while low dosage of garlic improves plasma viscosity and fibrinogen during exercise. So it is possible, consuming low dosage dosage (500 mg) of garlic before exercise by people with problem of hemeostasis, reduse cardiovascular risk during exercise. The aim of this study was to investigate the effects of consuming different dosages of garlic on responses of the main determinants of hemorheology to acute endurance exercise in. Fifteen healthy young men (mean ± SD; age 27.0 ± 8 years; weight 73.9 ± 6 kg and height 175.3 ± 4 cm) with at least 3 years’ experience of regular participation in running or martial had voluntarily participated in this study. Subjects took different dosages of garlic (500, 750 and 1000 mg) and starch (placebo), in four separate sessions in a form of capsul with one week between them. In each session, 4 hours after taking the capsul subjects performed 30 min of running on the treadmill. Before and 4 hours after taking the capsuls and immediately after exercise hemodynamic factors and blood samples were taken. Blood samples were analyzed for blood and plasma viscosity, fibrinogen, hematocrit, hemoglobin and red blood cells (RBC) count. Data were analyzed using the repeated measures of ANOVA with repeated measure. Data analysis revealed that garlic dosage had significant effect on the plasma viscosity and fibrinogen (p=0.001). Paired comparisons showed that decreases in these two factors were significantly higher in 500 mg dosage than the two other. However, dosage of garlic did not have any significant effect on the responses of blood viscosity, hematocrit, hemoglobin and red blood cells (P=0.067). Regardless of the dosage, consuming the garlic supplement acutly 4 hours before exercise resulted in reduction in resting level of hemorheological variables (P=0.000). In addition, consuming garlic and its dosage did not have any significant effect on responses hemorheological variables to endurance exercise (P=0.59). Based on the findings of the present study, it could be concluded that consuming the garlic supplement had improved all hemorheological factors, while low dosage of garlic improves plasma viscosity and fibrinogen during exercise. So it is possible, consuming low dosage dosage (500 mg) of garlic before exercise by people with problem of hemeostasis, reduse cardiovascular risk during exercise.

https://spj.ssrc.ac.ir/article_590_08b255a5d42b89b0585260b6f2360bdd.pdf

Sport Sciences Research Institute Sport Physiology 2322-164X 7 28 2016 02 20 Effect of 8 weeks resistance training on plasma irisin protein level and muscle FNDC5 and adipose tissue UCP1 genes expression in male rats Effect of 8 weeks resistance training on plasma irisin protein level and muscle FNDC5 and adipose tissue UCP1 genes expression in male rats 117 130 592 FA Jalil Reisi 0000-0002-3276-1598 Journal Article 2014 11 26 The purpose of this study was to determine the effect of 8weeks resistance training on plasma irisin protein level and expression of soleus muscle FNDC5 and subcutaneous adipose tissue UCP1 genes in male rats. 16 Sprague dolly male rats (w=211.5± 22.2 gr, 8 weeks) divided in 2(n=8) groups (8weeks resistance training and control group) randomly. Training group exercised 3 times per week for 8 weeks on a special ladder (1.2 meters height) and carried a weight of 50% of body weight, which was closed with their tails, began their training and reached to 200% of the body weight of rats in the final week. 3 sets of 5 reps with 3 minutes rest between training sessions and one minute between repetitions was done. ELISA method for measuring plasma irisin levels and real time PCR method was used for the relative expression of mRNA genes UCP1 and fndc5. Independent t test was used to compare group differences (α=0.05). Results showed that irisin protein levels after 8 weeks of resistance training significantly increased (p<0.001, t=4.48).Also the relative expression of m RNA genes FNDC5(p<0.001, t=6.18) and UCP1 (p<0.001, t=14.26) was significantly increased after exercise. It can be concluded from the present results that the resistance training through secretion of myokins like irisin may affect white adipose tissue. The purpose of this study was to determine the effect of 8weeks resistance training on plasma irisin protein level and expression of soleus muscle FNDC5 and subcutaneous adipose tissue UCP1 genes in male rats. 16 Sprague dolly male rats (w=211.5± 22.2 gr, 8 weeks) divided in 2(n=8) groups (8weeks resistance training and control group) randomly. Training group exercised 3 times per week for 8 weeks on a special ladder (1.2 meters height) and carried a weight of 50% of body weight, which was closed with their tails, began their training and reached to 200% of the body weight of rats in the final week. 3 sets of 5 reps with 3 minutes rest between training sessions and one minute between repetitions was done. ELISA method for measuring plasma irisin levels and real time PCR method was used for the relative expression of mRNA genes UCP1 and fndc5. Independent t test was used to compare group differences (α=0.05). Results showed that irisin protein levels after 8 weeks of resistance training significantly increased (p<0.001, t=4.48).Also the relative expression of m RNA genes FNDC5(p<0.001, t=6.18) and UCP1 (p<0.001, t=14.26) was significantly increased after exercise. It can be concluded from the present results that the resistance training through secretion of myokins like irisin may affect white adipose tissue.

https://spj.ssrc.ac.ir/article_592_dbe272bab69f8e13f14b405e038deb64.pdf

Sport Sciences Research Institute Sport Physiology 2322-164X 7 28 2016 02 20 The Effect Of 6 Weeks Endurance Training On BDNF Expression In Sensory Spinal Cord Of Rats With Diabetic Neuropathy The Effect Of 6 Weeks Endurance Training On BDNF Expression In Sensory Spinal Cord Of Rats With Diabetic Neuropathy 131 146 593 FA Rasoul Eslami Ghazaleh Sorkhkamanzadeh Reza Gharakhanlou Abdolreza Kazemi Abdolali Banaifar 0000-0002-8493-2053 Journal Article 2014 12 01 The aim of present study was to investigate the effect of 6 weeks of endurance training on gene expression of Brain Derived Neurotrophic Factor (BDNF) sensory roots of sciatic nerve in rats with diabetic neuropathy. Twenty-eight adult male Wistar rats in the body mass range of 326/3±8/4 gr, randomly assigned in to four groups: diabetic control, diabetic training, healthy control and healthy training. For inducing diabetic neuropathy, after twelve hours of food starvation, intraperitoneal injection of STZ solution (45 mg/Kg) method was used. Two weeks after STZ injection, the endurance training protocol was performed for six weeks and Twenty-four hours after the last training session, rats were sacrificed. Real-Time PCR was used for BDNF gene expression measurement. For data Analysis, Kruskal– Wallis and Mann-Whitney U Test were used (P≤0.05). Results indicate that diabetes decreases BDNF expression (10-folds) in sensory roots of sciatic nerve. However, 6 weeks of endurance training can partly compensate the BDNF expression decrease induced by diabetic neuropathy (P=0.043). This study shows that diabetes can decrease BDNF expression in sensory roots of sciatic nerve. however, this decrease can be reversible some deal by endurance. In summary, result of this study support this hypothesis that neurotrophic support decreases in diabetic neuropathy. The aim of present study was to investigate the effect of 6 weeks of endurance training on gene expression of Brain Derived Neurotrophic Factor (BDNF) sensory roots of sciatic nerve in rats with diabetic neuropathy. Twenty-eight adult male Wistar rats in the body mass range of 326/3±8/4 gr, randomly assigned in to four groups: diabetic control, diabetic training, healthy control and healthy training. For inducing diabetic neuropathy, after twelve hours of food starvation, intraperitoneal injection of STZ solution (45 mg/Kg) method was used. Two weeks after STZ injection, the endurance training protocol was performed for six weeks and Twenty-four hours after the last training session, rats were sacrificed. Real-Time PCR was used for BDNF gene expression measurement. For data Analysis, Kruskal– Wallis and Mann-Whitney U Test were used (P≤0.05). Results indicate that diabetes decreases BDNF expression (10-folds) in sensory roots of sciatic nerve. However, 6 weeks of endurance training can partly compensate the BDNF expression decrease induced by diabetic neuropathy (P=0.043). This study shows that diabetes can decrease BDNF expression in sensory roots of sciatic nerve. however, this decrease can be reversible some deal by endurance. In summary, result of this study support this hypothesis that neurotrophic support decreases in diabetic neuropathy.

https://spj.ssrc.ac.ir/article_593_acc3e0404646c57502b480dc052c4fe1.pdf