Effective Aerobic Training and Use of Vitamin E on Non-Alcoholic Fatty Liver in The Male Secondary School Students of Shahrood City

Document Type : Research Paper

Authors
Hossein Moradi 1
Nasrin Razavianzadeh 2
Ali Younesian 3
Elham Zahedi 4
1 M.Sc. of Sport Physiology, Department of Education, Shahrood
2 Assistant Professor,Islamic Azad University
3 Associate Professor of Sport Physiology, University of Shahrood
4 GP in Imam Hossein Hospital, Shahrood
10.22089/spj.2017.1802.1227
Abstract
The aim of this study was to determine the effect of aerobic exercise with vitamin E consumption on non-alcoholic fatty liver disease in people15 to 18 years. For this purpose,44 patients with an average age of 15.79±0.97 (years), Weight 95.10±13.08 (kg) and BMI of 31.46±3.22 (kg/m2) randomly divided into 4 groups of 11 persons (1. aerobic exercise with diet 2. Vitamin E with diet 3. Vitamin E +aerobic exercise with diet 4. Diet). Variables of Weight, body mass index, waist to hip ratio, blood sugar, cholesterol, triglycerides, low-density lipoprotein, high density lipoprotein, alanine aminotransferase, aspartate aminotransferase and elasticity of the liver was measured before and after 8 weeks intervention. The paired T-test and ANOVA showed that in comparison within groups decrease in indicators such as weight in the first, third and fourth groups, body mass index and waist-to-hip ratio in the first and third groups, triglyceride in the first and second groups, cholesterol in first and fourth groups, low-density lipoprotein in the fourth group, the second group and alanine amino transferase in second group and liver elasticity was significant in all groups (P<0.05). In comparison between groups and between variables except of high-density lipoprotein and cholesterol difference was not significant (P<0.05) that in Scheffe post hoc test results in favor of vitamin E with diet group were observed. So, it seems that aerobic exercise along with diet control or the daily intake of vitamin E(400IU) along with diet control have a significant role in the improvement or decline of nonalcoholic fatty liver disease. But to achieve the most effective way and a single treatment strategy requires further research.
Keywords
Fatty Liver
Aerobic Exercise
Diet
Vitamin E
Weight Loss

Main Subjects

  1. Kang H‌, Greenson J K, Omo J T, Chao C, Peterman D, Anderson L, et al. Metabolic syndrome is associated with greater histologic severity, higher carbohydrate, and lower fat diet in patients with NAFLD. Am J Gastroenterol. 2006‌; 101(10): 2247-53.
  2. Kopec K L‌, ‌Burns D. Nonalcoholic fatty liver disease: A review of the spectrum of disease, diagnosis, and therapy. Nutrition in Clinical Practice‌: Official Publication of the American Society for Parenteral and Enteral Nutrition. ‌2011a; 26(5): 565-‌76.
  3. Ekstedt M‌, Franz´en LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G, Kechagias S.‌ Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology. 2006; 44(4): 865-73
  4. Vajro P‌, Lenta S, Socha P, Dhawan A, McKiernan P, Baumann U, et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: Position paper of the ESPGHAN Hepatology Committee. J Pediatr Gastroenterol Nutr. 2012‌; 54(5): 700-13.
  5. Ludwig J, Viggiano T R, McGill D B, Oh B J. Nonalcoholic steatohepatitis: Mayo clinic experiences with hitherto unnamed disease. Mayo Clin Proc. 1980; 55(7): 434-8.
  6. Orangi E, Ostad Rahimi A, Mahdavi R, Somi M, Tarzemani M. Oxidative stress-related parameters and antioxidant status in non-alcoholic fatty liver disease patients. Ir J Endo & Metabo. 2011; 12(5): 493-9. (In Persian).
  7. Petta S, Muratore C, Craxì A. Non-alcoholic fatty liver disease pathogenesis: The present and the future. Dig Liver Dis. 2009; 41(9): 615–‌25.
  8. Marchesini G, Marzocchi R, Agostini F, Bugianesi E. Nonalcoholic fatty liver disease and the metabolic syndrome. Curr Opin Lipidol. 2005; 16(4): 421-7.
  9. Patton H M‌, Sirlin C‌, Behling C‌, Middleton M‌, Schwimmer J B‌, ‌Lavine J E. Pediatric nonalcoholic fatty liver disease: A critical appraisal of current data and implications for future research. Journal of Pediatric Gastroenterology and Nutrition. ‌2006; 43(4): 413-‌27.
  10. Chalasani N, Younossi Z, Lavine J E, Diehl A M, Brunt E M, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the american gastroenterological association, american association for the study of liver diseases, and american college of gastroenterology. Gastroenterology. 2012; 142(7): 1592–609. (In Persian).
  11. Straub B K, Schirmacher P. Pathology and biopsy assessment of non-alcoholic fatty liver disease. Dig Dis. 2010, 28: 197-202.
  12. De Piano A, Prado W L, Caranti D A, Siqueira K O, Stella S G, Lofrano M, et al. Biochenutritional profile of obese adolescent with non alcholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2007‌; 44(4): 446-52.
  13. Hasegawa T, Yoneda M, Nakamura K, Makino I, Terano A. Plasma transforming growth factor-β1 and efficacy of alpha-tocopherol in patients with nonalcoholic steatohepatitis: A pilot study. Aliment Pharmacol Ther. 2001; 15: 1667-72.
  14. Lavine J. Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study. J Pediatr. 2000; 136(6): 734-8.
  15. Lavine J E, Schwimmer J B, Van Natta M L, Kugelmas M‌, Hill D B‌, Vivian B‌, Marsano L‌, ‌McClain C J. Cytokines and NASH: A pilot study of the effects of lifestyle modification and vitamin E. Hepatology. 2003; 38: 413-‌,9.
  16. Chen S M, Liu C Y, Li S R, Huang H T, Tsai C Y, Jou H J. Effects of therapeutic lifestyle program on ultrasound-diagnosed nonalcoholic fatty liver disease. J Chin Med Assoc. 2008; 71: 551-8.
  17. Scaglioni F, Marino M, Ciccia S, Procaccini A, Busacchi M, Loria P, et al. Short-term multidisciplinary nonpharmacological intervention is effective in reducing liver fat content assessed non-invasively in patients with nonalcoholic fatty liver disease (NAFLD). Clin Res Hepatol Gastroenterol. 2013; 37: 353-‌8.
  18. ‌Nikroo H, ‌Attarzade Hosseini R‌. Sima‌H, Nematy M. The effect of diet and aerobic training on serum aminotransferases levels in patients with non-alcoholic steatohepatitis. Journal of Shahed University Profdoc, Scientific-Research. 2011; 18(93): 51 -60. (In Persian)
  19. Vajro P, Mandato C, Franzese A, Ciccimarra E, Lucariello S, Savoia M, et al. Vitamin E treatment in pediatric obesity-related liver disease: A randomized study. J Pediatr Gastroenterol Nutr. 2004; 38: 48–55.
  20. Nobili V, Manco M, Devito R, Ciampalini P, Piemonte F, Marcellini M. Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2006; 24: 1553–‌61.
  21. Mezey E‌, Potter J J‌, Rennie-Tankersley L‌, Caballeria J, Pares A. A randomized placebo controlled trial of vitamin E for alcoholic hepatitis. J Hepatol. 2004; 40: 40-6.
  22. Wang C L, Liang L, Fu J F, Zou C C, Hong F, Xue J Z, et al. Effect of lifestyle intervention on non-alcoholic fatty liver disease in Chinese obese children. World J Gastroenterol. 2008; 14: 1598– 602.
  23. Tock L, Prado W L, Caranti D A, Cristofalo D M, Lederman H, Fisberg M, et al. Nonalcoholic fatty liver disease decreases in obese adolescents after multidisciplinary therapy. Eur J Gastroenterol Hepatol. 2006; 18: 1241–‌5.
  24. R‌,‌Hazhir N, ‌‌Gharehbaghi M. Lifestyle intervention and vitamin E therapy in obese children with nonalcoholic fatty liver disease. Tabriz University of Medical Sciences, Journal of Comprehensive Pediatrics. 2012‌; 4(1): 62-5. (In Persian).
  25. Browning J D, Baker J A, Rogers T, Davis J, Satapati S, Burgess S C. Short-term weight loss and hepatic triglyceride reduction: Evidence of a metabolic advantage with dietary carbohydrate restriction. Am J Clin Nutr. 2011; 93: 1048-‌52.
  26. Elias M C, Parise E R, de Carvalho L, Szejnfeld D, Netto J P. Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease. Nutrition. 2010; 26: 1094-9‌.
  27. Ryan M C, Abbasi F, Lamendola C, Carter S, McLaughlin T L. Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults. Diabetes Care. 2007; 30: 1075-‌80.
  28. Spassiani N A, Kuk J L. Exercise and the fatty liver. Appl Physiol Nutr Metab. 2008‌; 33(4): 802-‌7.
Sport Physiology
Volume 9, Issue 34 - Serial Number 34
Summer 2017
July 2017
Pages 115-128

  • Receive Date 23 February 2016
  • Revise Date 15 August 2016
  • Accept Date 28 September 2016