Document Type : Research Paper
Authors
1 Associate Professor of Sport Physiology, Shahid Rajaee Teacher Training University
2 Professor of Sport Physiology, Tehran University
3 Ph.D. Student in Sport Cardiovascular and Respiratory Physiology, Shahid Rajaee Teacher Training University
4 Associate Professor of Physiology, Medicinal Plants Research Center, Yasuj University of Medical Sciences
Abstract
The aim of this study was to survey insulin resistance, serum adiponectin, serum FGF21 changes as metabolic cardiovascular risk factors following eight weeks of endurance, strength and compound training in sedentary obese children 8-12 Years Old. Sixty obese male children (age: 10.05±1.41 years old and BMI: 32.36±1.77 kg/m2) were randomly divided into four groups as follows: first group, endurance training; second group, resistance training; third group, compound training, fourth group, control. Exercise training performed 4 times per week for 8 weeks. Combined training was including 2 sessions of endurance training and 2 sessions of resistance training, separately. Blood samples were collected at before and after exercise trainings period to assess the variables. Analysis of variance (ANOVA) with repeated measurement and one-way ANOVA to assess variable changes in four groups was used in SPSS software, version 21. Results showed that insulin resistance decreased and serum adiponectin and serum FGF21 increased in training groups to control group (P<0.001). Serum adiponectin had most increased after endurance training protocol in comparison with resistance and combined training protocols (P<0.001). Therefore, three types exercise training that use this research, specially endurance training protocol could be considered as an appropriate and non-medication approaches to prevent and reduce the metabolic cardiovascular risk factors and obesity-related disorders in obese children.
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- Molinari-Büchi B, Barth J, Janner M, Frey P. Overweight and obesity in children: known facts and new trends. Revue médicale suisse. 2010; 6(249):1022-5.
- Abramson GL, Vaccarino V. Relationship between physical activity and inflammation lipid profile among apparently healthy middle-aged older adults. Arch, Med. 2002;16(11). 1286-92.
- Hamedinia M, Haghighi A, Sardar MA, PoorJahad J. Effect of training in water on serum adiponectin and insulin resistance in obese children and adolescents. Metabolism and Exercise. 2012;2(2), 125-33. (In Persian)
- Lloyd-Jones D, Adams R, Carnethon M, de Simone G, Ferguson TB, Flegal K, et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009; 119:480–6.
- Worldo meters information site. Find in June 2016. http://www.Worldometers.info
- Siahkoohyan M. Effects of aerobic exercise on apoB.apoA1 and LDL size in middle-aged men. Ph.D. Thesis. Tarbiat Modares University. 2001; 34. (In Persian)
- Taghian F, Esfarjani F, Mirsafaei R. The relationship between leptin level changes with some cardiovascular risk factors in obese girls in aerobic training effect. Research in Sport Sciences. 2010;2, 73-86. (In Persian)
- Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008; 300: 197–208.
- Atashak S, Jafari A, Azarbaijani MA. The long-term effects of resistance training on adiponectin and lipid profile in obese men. Razi Journal of Medical Sciences. 2011;18(86): 1-11. (In Persian)
- Bizheh N, Abbasian S. Comparison of the effect of Ramazan month`s fasting and regular aerobic exercise on indicators of Lipocalin-2, lipid profile and insulin resistance in inactive obese individuals. Razi Journal of Medical Sciences. 2013;20(111): 16-30. (In Persian)
- Sypniewska G. Laboratory assessment of cardiometabolic risk in overweight and obese children. Clinical Biochemistry. clin biochem. 2015;12-24.
- Besse-Patin E, Montastier C, Vinel I, Castan-Laurell K, Louche C, Dray A, et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. International Journal of Obesity. 2013;158.
- Kim KH, Kim SH, Min YK, Yang HM, Lee JB, Lee MS. Acute exercise induces FGF21 expression in mice and inhealthy humans. PloSOne. 2013; 7;8(5): 63517.
- Fazelifar S, Khosrow E, Vaghinak S. effect of 12 weeks of concurrent training and 4 weeks of detraining on serum adiponectin concentrations and physical fitness levels in obese boys. Rev Bras Med Esporte. 2013; 19(5): 349-54.
- Akbarpour M. The Effect of Aerobic Training on Serum Adiponectin and Leptin Levels and Inflammatory Markers of Coronary Heart Disease in Obese Men. Middle-East Journal of Scientific Research. 2013; 13(8):1043-50.
- Ko BJ, Kim SM, Park KH, Park HS, Mantzoros CS. Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children. Int J Obes (Lond). 2014 Dec;38(12):1497-502.
- Taniguchi H, Kumpei T, Xiaomin S, Zhen-Bo C, Satomi O, Ryuken I, et al. Cardiorespiratory Fitness and Visceral Fat Are Key Determinants of Serum Fibroblast Growth Factor 21 Concentration in Japanese Men. The Journal of Clinical Endocrinology & Metabolism. 2014 Oct; 99(10): 1877-84.
- Nazem MR, Imami A, Yaghmaei B, Shekarriz R, Hedaiati M. Serum adiponectin levels in people with low and subclinical hyperthyroid. Journal of Endocrinology and Metabolism of Iran. Shahid Beheshti University of Medical Sciences and Health Services. 2013;15(3): 279-284. (In Persian)
- Loger L, Lambert JA. Maximal multistage 20 m shuttle run test to predict V02 max. Eur J Appl Physiol 1982; 49: 1-12.
- Azucena MB, Jorge MH, Mardia LA. Diagnostic methods of insulin resistance in a pediatric population. Bol Med Hosp Infant Mex 2011;68(5):367-73.
- Arias-Loste MT, García-Unzueta MT, Llerena S, Iruzubieta P, Puente A, Cabezas J, Alonso C, et al. Plasma betatrophin levels in patients with liver cirrhosis. World journal of gastroenterology: WJG. 2015 Oct 7; 21(37): 10662.
- Avery D, Faigenbaum Ed.D, Barbara A. Resistance Training for Obese Children and Adolescents. President’s Council on Physical Fitness and Sports Washington, D.C. 2007; 8(3): 2-8.
- Frost GO, Bar-Or JD, Dyson k. Explaining differences in the metabolic cost and efficiency of treadmill locomotion in children. Journal of Sports Science. 2002; (6): 451-61.
- Katie W, Timothy WJ, Elizabeth AD, Daniel G. Exercise Training in Obese Children and Adolescents, Current Concepts. Sports Med. 2005; 35 (5): 375-392.
- Julia MK. Safe exercise prescription for children and adolescents. Paediatr Child Health. 1998; 3 (5): 337-43.
- Walter RT, Neil FG, Linda SP. ACSM’s guidelines for exercise testing and prescription. 8th ed. American College of Sports Medicine. 2010; 112-34.
- Tanaka H, Monahan KG, Seals DS. Age – predicted maximal heart rate revisited. J Am Coll Cardiol. 2001; 37: 153-6.
- Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JFP, Dela F. Strength training increases in insulin mediated glucose uptake, GLUT4, content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes. 2004; 53: 294-305.
- Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor -α: direct role in obesity-linked insulin resistance. Sciences. 1993;259: 87-91.
- Kriketos AD, Gan SK, Poynten AM, Furler SM, Chisholm DJ, Campbell LV. Exercise increases adiponectin levels and insulin sensitivity in humans. Diabetes care. 2004 Feb 1; 27(2): 629-30.
- Pan DA, Lillaja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH. Skeletal muscle triglycride levels are inversely reated to insulin action. Diabetes. 1997; 46: 983-8.
- Poehlman ET, Dvorak RV, DeNino WF, Brochu M, Ades PA. Effect of resistance training and endurance training on insulin sensitivity in no obese, young women: A controlled randomized trial. J.Clin.Endocrino. Metab. 2000;85: 2463-8.
- Hara T, Fujiwara H, Nakao H, Mimura T, Yoshikawa T, Fujimoto S. Body composition is related to increase in plasma adiponectin levels rather than training in young obese men. European journal of applied physiology. 2005 Aug 1; 94(5-6): 520-6.
- Mitsnefes M, Kartal J, Khoury P, Daniels S. Adiponectin in children with chronic kidney disease: role of adiposity and kidney dysfunction. Clin J Am Soc Nephrol. 2007; 2: 46-50.
- Cuevas-Ramos D, Almeda-Valdes P, Meza-Arana CE, Brito-Cordova G, Gomez-Perez FJ, et al. Exercise Increases Serum Fibroblast Growth Factor 21 (FGF21) Levels. PLoS One. 2012; 7: 38022.
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