Effects of Aerobic Exercise and Calorie Restriction (Low-Carb Diet and Standard Diet) on Adipokines Affecting Insulin Resistance in Rats with Type 2 Diabetes

Document Type : Research Paper

Authors
Hosein Dastbarhagh 1
Mehdi Kargar Fard 2
Effat Bambaechi 3
Hassan Ali Abedi 4
1 Ph.D. Students at Sport Physiology, University of Isfahan
2 Professor of Sport Physiology, University of Isfahan
3 Associate Professor of Sport Physiology, University of Isfahan
4 Assistant Professor of Medicine Physiology, Jahroom University of Medical Sciences
10.22089/spj.2017.4283.1572
Abstract
The aim of this study was to evaluate the interactive effects of calorie restriction (standard diet and low-carb diet) in combination with aerobic exercise on the adipokines that are affective on insulin resistance in type 2 diabetic male rats. In an experimental study, 48 male Wistar rats (age 10 weeks, weight 229±19.5g) were randomly divided equally into six groups after diabetes induction. Group1: Diabetic control, group 2: 20% negative balance calorie with aerobic exercise, group 3: 20% caloric restriction with standard diet, group4: 20% caloric restriction with low carbohydrate diet, group 5: 20% caloric restriction with standard diet + aerobic exercise and group6: 20% calorie restriction with low-carb diet + aerobic exercise. Then 20% of negative energy balance was carried out on a daily basis of all groups for 8 weeks. Results showed that exercise alone and in combination with low-carb diet caused a significant increase in the Omentin-1 compared to diabetic control group (P≤0.05). But no significant differences were observed in the chemerin between the experimental groups with diabetic control group. The results also showed that the standard diet group and the low-carbohydrate diet alone and in combination with exercise were significantly improved insulin resistance (P≤0.05). This study showed that combination of aerobic exercise and low carbohydrates diet can increase Omentin-1 and improve insulin sensitivity in rats with type 2 diabetes.
Keywords
Omentin-1
Chemerin
Insulin Resistance
Exercise
Diet
Calorie Restriction

Main Subjects

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Sport Physiology
Volume 9, Issue 36 - Serial Number 36
Winter 2018
January 2018
Pages 173-188

  • Receive Date 05 June 2017
  • Revise Date 05 September 2017
  • Accept Date 18 September 2017