Document Type : Research Paper

Authors

1 Assistant Professor of Sport Physiology, Payame Noor University (PNU), Tehran, Iran

2 Heart and Thorax Surgeon, Physical Medicine Specialist

3 M.Sc. in Sport Sciences, Sport Sciences Research Institute

Abstract

This study examined the effects of melatonin supplementation on cardiac function after exhaustive exercise in the active elderly. The sample consisted of 8 active elderly between the ages of 50 and 65 years (mean age of 65.8±5.9, height of 168.1±7.2, and weight of 74.7±8.7) who had at least two exercise session at week. The research had executed by crossover, double-blinded, placebo and supplement plan. After explanation, subjects signed consent form; and changes in heart rate, contraction of cardiovascular and hemodynamic rest period before exercise and during active recovery after exercise were measured by electrocardiography and cardio screen devices. Data analysis was performed by two-way ANOVA with repeated measurements and Bonferroni post hoc test. The results showed that melatonin supplements significantly improved heart rate recovery after exercise, also had no significant improvement in oxygen consumption. The supplement had no effect on resting heart rate and vascular resistance to blood. According to the results, melatonin had a moderating influence on sympathetic system, and it is a beneficial effect in elderly people during sports activities. Therefore, more research is needed to draw firm conclusions and test higher doses.

Keywords

Main Subjects

  1. McDonald K G, Grote S, Shoepe T C. Effect of training mode on post-exercise heart rate recovery of trained cyclists. Journal of Human Kinetics. 2014; 41(1): 43-9.
  2. Imai K, Sato H, Hori M, Kusuoka H, Ozaki H, Yokoyama H, et al. Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. Journal of the American College of Cardiology. 1994; 24(6): 1529-35.
  3. Maeder M T, Ammann P, Rickli H, Brunner-La Rocca H P. Impact of the exercise mode on heart rate recovery after maximal exercise. European Journal of Applied Physiology. 2009; 105(2): 247-55.
  4. Camm, A.J., Malik, M., Bigger, J.T., Breithardt, G., Cerutti, S., Cohen, R.J., Coumel, P., Fallen, E.L., Kennedy, H.L., Kleiger, R.E. and Lombardi, F. Heart rate variability standards of measurement, physiological interpretation, and clinical use. Eur Heart J. 1996; 17: 354-81.
  5. Adel Mazlomi Jn S. Heart rate variability is one of the common indicators in the evaluation of workload in ergonomics. Iran Occupational Health Journal. 2010; 7(3): 1-3. (In Persian).
  6. Cole C R, Foody J M, Blackstone E H, Lauer M S. Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Annals of Internal Medicine. 2000; 132(7): 552-5.
  7. Hakola L, Komulainen P, Hassinen M, Savonen K, Litmanen H, Lakka T, et al. Cardiorespiratory fitness in aging men and women: The DR's EXTRA study. Scandinavian Journal of Medicine & Science in Sports. 2011; 21(5): 679-87.
  8. Scalbert E, Guardiola-Lemaitre B, Delagrange P. Melatonin and regulation of the cardiovascular system. Therapie. 1997; 53(5): 459-65.
  9. Murray M T. Encyclopedia of nutritional supplements. Prima Pub; 1996. 45-167.
  10. Elène Girouard H, Denault C, Chulak C, De Champlain J. Treatment by N-acetylcysteine and melatonin increases cardiac baroreflex and improves antioxidant reserve. American Journal of Hypertension. 2004; 17(10): 947-54.
  11. Atkinson G, Drust B, Reilly T, Waterhouse J. The relevance of melatonin to sports medicine and science. Sports Medicine. 2003; 33(11): 809-31.
  12. Kenny J. The dose- response effects of melatonin ingestion on sustained exercise, thermoregulation and associated neurobehavioral assessments. Proquest Document. 2006: (3):323-9.
  13. Reiter, Russel J, Robinson, Jo. Melatonin: Your body's natural wonder drug. Bantam. 1995.
  14. Oberg P A T T, Tamura T. Biomedical transducers and instruments. CRC Press; 1997. 200-324
  15. Grady G O J P H. Handbook of phase I/II clinical drug trials. CRC Press; 1997. 23-45.
  16. Alireza Zali N E. Heart rate variability. Beheshti University of Medical Journal. 1391; 36(3): 163-6. (In Persian).
  17. Moan R J. Food doping and sports performance. Tehran: Iran Olympic Committee Publications; 1380. 28-187. (In Persian).
  18. Važan R, Styk J, Béder I, Pancza D. Effect of melatonin on the isolated heart in the standard perfusion conditions and in the conditions of calcium paradox. Gen Physiol Biophys. 2003; 22: 41-50.
  19. Escames G, Ozturk G, Baño‐Otálora B, Pozo M J, Madrid J A, Reiter R J, et al. Exercise and melatonin in humans: Reciprocal benefits. Journal of Pineal Research. 2012; 52(1): 1-11.
  20. Bosnian H, Dormehl I, Hugo N, Redelinghuys I, Theron J. The effect of intravenous administration of melatonin on cardiovascular parameters of the baboon (Papio ursinus). Journal of Pineal Research. 1991; 11(3‐4): 179-81.
  21. Siof Jahromi M, Chobine S, Rahimi M. The effect of melatonin on cardiovascular indices during exercise. Military Medical Journal of the Islamic Republic of Iran. 2011; 1: 6-11. (In Persian).
  22. Chiodera P, Volpi R, Capretti L, Giuliani N, Maffei M, Coiro V. Effect of melatonin on arginine vasopressin secretion stimulated by physical exercise or angiotensin II in normal men. Neuropeptides. 1998; 32(2): 125-9.
  23. Millar-Craig M, Bishop C, Raftery E. Circadian variation of blood-pressure. The Lancet. 1978; 311(8068): 795-7.
  24. Turton M, Deegan T. Circadian variations of plasma catecholamine, cortisol and immunoreactive insulin concentrations in supine subjects. Clinica Chimica Acta. 1974; 55(3): 389-97.
  25. Nishiyama K, Yasue H, Moriyama Y, Tsunoda R, Ogawa H, Yoshimura M, et al. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men. American Heart Journal. 2001; 141(5): 13A-17A.
  26. Behar S, Halabi M, Reicher-Reiss H, Zion M, Kaplinsky E, Mandelzweig L, et al. Circadian variation and possible external triggers of onset of myocardial infarction. The American Journal of Medicine. 1993; 94(4): 395-400.
  27. Gallerani M, Manfredini R, Ricci L, Cocurullo A, Goldoni C, Bigoni M, et al. Chronobiological aspects of acute cerebrovascular diseases. Acta Neurologica Scandinavica. 1993; 87(6): 482-7.
  28. Brugger P, Marktl W, Herold M. Impaired nocturnal secretion of melatonin in coronary heart disease. The Lancet. 1995; 345(8962): 1408.
  29. Sakotnik A, Liebman P, Stoschitzky K, Lercher P, Schauenstein K, Klein W, et al. Decreased melatonin synthesis in patients with coronary artery disease. European Heart Journal. 1999; 20(18): 1314-7.