Effect of High Intensity Interval Training on miR-1, miR133-a Gene Expression in Rats with Myocardial Infarction

Document Type : Research Paper

Authors
Pedram Ghorbani 1
Mohammad Reza Kordi 2
Abbasali Gaeini 3
Reza Noori 4
Sara Karbalaeifar 1
1 Ph.D. Student of Sport Physiology, University of Tehran, Kish International Campus
2 Associate Professor of Sport Physiology, University of Tehran
3 Professor of Sport Physiology, University of Tehran
4 Assistant Professor of Sport Physiology, University of Tehran, Kish International Campus
10.22089/spj.2018.1151
Abstract
The aim of this study was to investigate the effect of intensive interval training on ‌‌miR-1, miR133-a gene expression in rats with myocardial infraction. For this purpose, 12 Wistar male rats with 10 weeks old and average weight 250-300gr that infected to Myocardial infarction and they were designed in to two groups of experimental (60 minutes of interval running on treadmills that each interval is 4 minutes of running with the 85-90 percent of Vo2max and 2 minutes of active rest at 50-60 percent of Vo2max for four days in a week and 6 weeks) and control group (without any training). Genes expression was investigated by the PCR technique and data were analyzed by the SPSS 18 with T test (α≤0.05). The findings of present study showed that the levels of miR-1 in high intensity interval training (4.33mg.ml-1) significantly much more than the control group (3.541mg.ml-1)(P=0.012) and the amount of miR-133a in high intensity interval training group (4.876 mg.ml-1) was also much more than control group (1.01mg.ml-1)(P≤0.001) . in general, 6 weeks of high intensity interval training with intensity of 50-60 percent of Vo2max leads to increased expression of miR-1 and miR-133a in male Vistar rats with MI.
Keywords
miR133-a
miR-1
HIIT
Male Rats
myocardial infarction

Main Subjects

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Sport Physiology
Volume 10, Issue 37
Spring 2018
April 2018
Pages 87-98

  • Receive Date 16 June 2016
  • Revise Date 16 October 2016
  • Accept Date 23 October 2016