Document Type : Research Paper
Authors
1 Ph.D. of Sport Biochemistry and Metabolism, Azad University, Central Tehran Branch
2 Professor of Sport Physiology, Azad University, Central Tehran Branch
3 Associate Professor of Biochemistry, Shahid Beheshti University of Medical Sciences
4 M. Sc. of Sport Physiology, Shahid Beheshti University of Medical Sciences
5 M. Sc. of Sport Physiology, Razi University
Abstract
The purpose of this study was to determine the effects of resveratrol supplementation and Aerobic training on protein levels of SIRT-1, PGC-1α and UCP-1 soleus muscle and Ingoinal abdominal subcutaneous adipose tissue in adult male Wistar rats. In this study, 32 male rat (w=260+10gr, 8 weeks) divided into 4(n=8) groups: control(C), aerobic training (T), complement-training (T-R) and supplements(S) randomly. Training groups exercised for 12 weeks (5 sessions a week, each session 45 minutes on a treadmill. ELISA (sandwich double) was used to measure tissue protein UCP-1, SIRT1, PGC-1α. ANOVA test used for data analysis and statistical significance (P≤0.05) were considered. Increased SIRT1 and PGC-1α protein changes in T-R and S groups in muscle tissue and subcutaneous white adipose tissue, respectively (P≤0.001) and (P≤0.05). Showed that the protein UCP-1 is also a significant increase in subcutaneous white adipose tissue after workouts (P≤0.001). According to the results probably resveratrol supplementation with aerobic physical activity a stronger impact on increasing the SIRT-1, PGC-1α soleus muscle and inguinal adipose tissue and UCP-1 inguinal adipose tissue to use separately or supplement physical activity resveratrol and white fat and is likely to change subcutaneous white adipose tissue to beige or intermediate phenotype.
Keywords
Main Subjects
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