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The Effect of Six Weeks' Interval Training on Tumor Volume and Adipose and Muscle Tissue Levels of Adiponectin and Leptin in Breast Cancer Bearing Female Mice

Document Type : Research Paper

Authors

1 Associate Professor of Sport Physiology, Tarbiat Modares University

2 M.Sc. in Sport Physiology, Tarbiat Modares University

3 Associate Professor of Sport Physiology, Shahid Rajaee Teacher Training University

Abstract

Cachexia is one of the main cancer Complications. Changes in adipokines levels such as leptin and adiponectin have effective role in accelerating and slowing down of Cachexia process. Exercise training is effective strategy to combating with cachexia. However, the involving mechanism is unknown. In this context, the aim of present study was to investigate the effect of six weeks' interval training on muscular and adipose tissue levels of adiponectin and leptin in mice's with breast cancer. For this purpose, 20 female Balb/c mice with 6-8 weeks' age and means weight 14-15g, almost 10 days after Cancerous with cell line injection, assigned in two control and interval group. Mice's in interval training group performed 10 intervals (two min) with 70 percent of Vmax and immediately performed two min active recovery with 50 percent of Vmax. This training program continued for six weeks and performed with five sessions in week. Finally, visceral adipose tissue and Gastrocnemius muscle was removed and given factors was determined with ELISA method. Tumor volume measured with digital caliper. For data analyze the independent t test were used. Results indicated significant increase in adipose tissue adiponectin (P=0.013) and decrease of leptin in muscle (P=0.025) and adipose tissue (P=0.000). furthermore, decrease muscle atrophy and decrease tumor volume in exercised group observed. it seems that positive effectiveness of exercise training in decrease muscular wasting of cancerous subjects is related to modify adipokines levels such as leptin and adiponectin.

Keywords

Main Subjects

References
  1. Shou J, Lai Y, Xu J, Huang J. Prognostic value of FOXA1 in breast cancer: A systematic review and meta-analysis. Breast. 2016; 27:35-43.
  2. Klimek ME, Aydogdu T, Link MJ, Pons M, Koniaris LG, Zimmers TA. Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. Biochem Biophys Res Commun. 2010;391(3): 1548-54.
  3. Nieman KM, Romero IL, Van Houten B, Lengyel E. Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta. 2013;1831(10):    1533-41.
  4. Piorkowska K, Oczkowicz M, Różycki M, Ropka-Molik K, Piestrzyńska-Kajtoch A. Novel porcine housekeeping genes for real-time RT-PCR experiments normalization in adipose tissue: Assessment of leptin mRNA quantity in different pig breeds. Meat Sci. 2011;87(3):191-5.
  5. Linkov F, Burke LE, Komaroff M, Edwards RP, Lokshin A, Styn MA, et al. An exploratory investigation of links between changes in adipokines and quality of life in individuals undergoing weight loss interventions: Possible implications for cancer research. Gynecol Oncol. 2014;133(1):67-72.
  6. Chai SB, Sun F, Nie XL, Wang J. Leptin and coronary heart disease: A systematic review and meta-analysis. Atherosclerosis. 2014;233(1):3-10.
  7. Cabıoğlu MT, Ergene N. Changes in serum leptin and beta endorphin levels with weight loss by electroacupuncture and diet restriction in obesity treatment. Am J Chin Med. 2006;34(1):1-1.
  8. Ceddia RB. Direct metabolic regulation in skeletal muscle and fat tissue by leptin: Implications for glucose and fatty acids homeostasis. Int J Obes (Lond). 2005;29(10):1175-83.
  9. Dyck DJ. Leptin sensitivity in skeletal muscle is modulated by diet and exercise. Exerc Sport Sci Rev. 2005;33(4):189-94.
  10. Machado AP, Rosa LF, Seelaender MC. Adipose tissue in Walker 256 tumour-induced cachexia: Possible association between decreased leptin concentration and mononuclear cell infiltration. Cell Tissue Res. 2004;318(3):503-14.
  11. Dalamaga M, Diakopoulos KN, Mantzoros CS. The role of adiponectin in cancer: A review of current evidence. Endocr Rev. 2012;33(4):547-94.
  12. Cheng KK, Lam KS, Wang B, Xu A. Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin. Best Pract Res Clin Endocrinol Metab. 2014;28(1):3-13.
  13. Liu Y, Sweeney G. Adiponectin action in skeletal muscle. Best Pract Res Clin Endocrinol Metab. 2014;28(1):33-41.
  14. Kelesidis I, Kelesidis T, Mantzoros CS. Adiponectin and cancer: A systematic review. Br J Cancer. 2006;94(9):1221-5.
  15. Maccio A, Madeddu C, Mantovani G. Adipose tissue as target organ in the treatment of hormone-dependent breast cancer: New therapeutic perspectives. Obes Rev. 2010;7(4):54-6.
  16. Mantovani G, Madeddu C, Macciò A. Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome. Drug Des Devel Ther. 2013; 7:645-56.
  17. Khamoui AV, Park BS, Kim DH, Yeh MC, Oh SL, Elam ML, et al. Aerobic and resistance training dependent skeletal muscle plasticity in the colon-26 murine model of cancer cachexia. Metabolism. 2016;65(5):685-98.
  18. Karami BL, Nuri R, Maghaddasi M, Tahmasebi S, Talei A. The effect of 12 weeks of walking on plasma levels of Leptin in postmenopausal women with breast cancer. Journal of Sport Biosciences.2011;2(8):107-21.
  19. Moghadasi M, Nouri R. Effects of 12 Weeks walking on plasma adiponectin concentration in postmenopausal women with breast cancer. Iran J Endocrinol Metab. 2012;14(1):47-52.
  20. Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, Bustos M, Martínez JA, Moreno-Aliaga MJ. Role of obesity-associated dysfunctional adipose tissue in cancer: A molecular nutrition approach. Biochimica et Biophysica Acta (BBA)-Bioenergetics. 2011;1807(6):664-78.
  21. Pedersen L, Idorn M, Olofsson GH, Lauenborg B, Nookaew I, Hansen RH, et al. Voluntary running suppresses tumor growth through epinephrine-and IL-6-dependent NK cell mobilization and redistribution. Cell Metab. 2016;23(3):554-62.
  22. Almeida PWM, Gomes-Filho A, Ferreira AJ, Rodrigues CEM, Dias-Peixoto MF, Russo RC, et al. Swim training suppresses tumor growth in mice. J Appl Physiol. 2009;107(1):261-5.
  23. Woods JA, Davis JM, Kohut ML. et al. (1994). Effects of exercise on the immune response to cancer. Med Sci Sports Exerc. 26(9):1109–15.
  24. Shamsi MM, Chekachak S, Soudi S, Quinn LS, Rangbar K, Chenari J, et al. Combined effect of aerobic interval training and selenium nanoparticles on expression of IL-15 and IL-10/TNF-α ratio in skeletal muscle of 4T1 breast cancer mice with cachexia. Cytokine. 2017; 90:100-8.
  25. Shalamzari SA, Agha-Alinejad H, Alizadeh S, Shahbazi S, Khatib ZK, Kazemi A, et al. The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice. Iran J Basic Med Sci. 2014;17(4):         231-58.
  26. Hayes JP, Chappell MA. Individual consistency of maximal oxygen consumption in deer mice. Functional Ecology. 1990; 1:495-503.
  27. Høydal MA, Wisløff U, Kemi OJ, Ellingsen Ø. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. Eur J Cardiovasc Prev Rehabil. 2007;14(6):753-60.
  28. Jones LW, Viglianti BL, Tashjian JA, Kothadia SM, Keir ST, Freedland SJ, et al. Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. J Appl Physiol. 2010;108(2):343-8.
  29. Khori V, Shalamzari SA, Isanejad A, Alizadeh AM, Alizadeh S, Khodayari S, et al. Effects of exercise training together with tamoxifen in reducing mammary tumor burden in mice: Possible underlying pathway of miR-21. Eur J Pharmacol. 2015.765:179-87.
  30. Amini. A, Gaeini. A, Chobineh. S, Kordi. M. R, Alizadeh. S. The effects of Aerobic training on expression of BcL2 and miR-15 and BcL2 protein in tumor tissue in mice with breast cancer. Sport Physiol. 2017; 32:85-100.
  31. Pedersen L, Christensen JF, Hojman P. Effects of exercise on tumor physiology and metabolism. Cancer J. 2015;21(2):111-6.
  32. Bing C, Trayhurn P. Regulation of adipose tissue metabolism in cancer cachexia. Curr Opin Clin Nutr Metab Care. 2008;11(3):201-7.
  33. Lira FS, Neto JC, Seelaender M. Exercise training as treatment in cancer cachexia. Appl Physiol Nutr Metab. 2014; 39(6):679-86.
  34. Dalamaga M. Interplay of adipokines and myokines in cancer pathophysiology: Emerging therapeutic implications. World J Exp Med. 2013;3(3):26-33.
  35. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11(2):85-97.
  36. Jardé T, Caldefie-Chézet F, Goncalves-Mendes N, Mishellany F, Buechler C, Penault-Llorca F, et al. Involvement of adiponectin and leptin in breast cancer: Clinical and in vitro studies. Endocrine-related cancer. 2009;16(4):1197-210.
  37. Chen DC, Chung YF, Yeh YT, Chaung HC, Kuo FC, Fu OY, et al. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer letters. 2006;237(1):109-14.
  38. Kim HJ, Kim HJ, Yun J, Kim KH, Kim SH, Lee SC, Bae SB, Kim CK, Lee NS, Lee KT, Park SK. Pathophysiological role of hormones and cytokines in cancer cachexia. J Korean Med Sci. 2012; 27(2):128-34.
  39. Donatto FF, Neves RX, Rosa FO, Camargo RG, Ribeiro H, Matos-Neto EM, Seelaender M. Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats. Cytokine. 2013; 61(2):426-32.
Sport Physiology
Volume 10, Issue 40
Winter 2019
January 2019
Pages 17-32
Files
History
  • Receive Date: 15 March 2017
  • Revise Date: 10 June 2017
  • Accept Date: 17 June 2017
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