Effect of Six Weeks Endurance Training on Gene Expression of Apoptotic and Anti-Apoptotic in Left Ventricle Cardiac of Elderly Male Rats

Document Type : Research Paper

Authors
Atefeh Ahmadnia 1
Mohamad Fashi 2
Mohammad Reza Asad 3
1 M.Sc. of Sport Physiology, Payame Noor University of karaj
2 Assistant Professor of Sport Physiology, Shahid Beheshti University of Tehran
3 Associate Professor of Sport Physiology, Payame Noor University
10.22089/spj.2018.4865.1656
Abstract
The aim of this study was to evaluation the effect of 6 weeks continuous endurance training (CET) on Caspase-3 and metallothionein-2 in left ventricular Cardiac tissue of male rats.14 elderly male rats divided to two group’s control (n=7) and endurance training (n=7) (65% - 70% maximum speed). Gene expression of Caspase-3 and metallothionein-2 were assessment by Real time - PCR and the quantification of gene expression levels using the formula 2-ΔΔct were used by Independent t-test. The results showed that the 6 weeks of d CET leads to non-significant decrease in Gene expression of Caspase-3 (P=0.078) and non-significant increase of metallothionein-2 (P=0.513). It seems, continuous endurance training does not to cause apoptotic damage in elderly people and can be used in this population.
Keywords
Caspase-3
Metallothionein-2
Left Ventricular Tissue
Continuous Endurance Activity
Apoptosis

Main Subjects

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Sport Physiology
Volume 11, Issue 42 - Serial Number 42
Summer 2019
August 2019
Pages 31-46

  • Receive Date 05 October 2017
  • Revise Date 05 March 2018
  • Accept Date 07 April 2018