The Effect of Different Intensities Endurance and Resistance Training on Expression Mir-133a and Two Transcription Factors of Osteogenic and Adipogenic, Runx2 and Pparγ on Bone Marrow in Old Male Wistar Rats

Document Type : Research Paper

Authors

1 Ph.D. Student in Exercise Physiology, Department of Exercise Physiology, Faculty of Literature and Humanies, Shahrekord University, Shahrekord, Iran

2 Associate Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Literature and Humanies, Shahrekord University, Shahrekord, Iran

3 Associate Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Literature and Humanies, Shahrekord University, Shahrekord

4 Professor of Clinical Sciences, Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran

Abstract

Objective: aging is known as a low bone mass and microarchitectural deterioration of bone tissue, resulting in increased risk of fracture. However, appropriate exercise for the prevention and treatment of osteoporosis has not been determined. The aim of this study was to determine the effects of compare effects of aerobic and resistance exercise training protocols with different intensities on microRNA-133a (mir-133a), Runx2 and Peroxisome proliferator-activated receptors-gamma (PPARγ) in bone marrow Wistar elderly rats. This experimental study was done on 40 Wistar male rats (23-month-old and with an average weight of 441.75 gram). They were randomly divided into five equal groups (n=8) include moderate (60% Maximum voluntary carrying capacity) or high (80% Maximum voluntary carrying capacity) intensity resistance training, moderate (60-110% Maximum speed) or high (80-110% Maximum speed) intensity endurance training and control. The two training groups completed 8 weeks of training program, 5 days a week according to resistance or endurance protocols. After completing training, expression of mir-133a, Runx2 and PPARγ on bone marrow were measured RT-PCR. The statistical analysis was performed using Kruskal-Wallis test with significance level of P

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Main Subjects

References

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Sport Physiology
Volume 11, Issue 42 - Serial Number 42
Summer 2019
August 2019
Pages 61-78

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History

  • Receive Date: 21 July 2018
  • Revise Date: 03 November 2018
  • Accept Date: 11 November 2018

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