Document Type : Research Paper
Authors
1 Ph.D. Student in Exercise Physiology, University of Tehran
2 Associate Professor of Exercise Physiology, University of Tehran
3 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract
One of the major aging mechanism is telomere shortening that affected by factors such as telomerase and SIRT6. Exercise may have effective role in delaying aging and increase telomerase enzyme activity. However, these mechanisms are unknown. In this context, the aim of present study was to determine the effect of eight weeks high intensity interval training (HIIT) on serum levels of telomerase enzyme and SIRT6 protein in aged men. For this purpose, twenty aged men with average age of 63±8 years, 71.03±5.78 kg, body mass index 24.49±3.25 kg/m2 and height 170.79±5/92 cm assigned into two control and HIIT groups. Subjects in HIIT group beginning the sprint training program with intensity of 90% reserve heart rate with three sets and three repetitions, and finally reached to five sets and six repetitions, but intensity maintained. Training program perform three time in week for eight weeks. At the end of training period, blood samples collected and experimental factors measured with Elisa method. for data analyze, covariance analysis and dependent t test used. Results of present study represent significant increase in SIRT6 protein and telomerase enzyme in HIIT group than to control group. Therefor respect to downregulation of telomerase activity and SIRT6 protein with aging, exercise training can be effective in compensate this decrease and delaying aging, and effectiveness pathway of exercise training in aged people can be partly related to increase in mentioned factors (telomerase enzyme and SIRT6 protein).
Keywords
Main Subjects
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