Exercise and Training Effects on Platelet Activation and Function: A Review Article

Document Type : Review Article

Authors

1 Associate Professor of Exercise Physiology, Shahid Beheshti University

2 Ph.D. Student in Exercise Physiology, Shahid Beheshti University

3 Post-Doctoral Researcher in Exercise Physiology, Shahid Beheshti University

Abstract

Platelets play an important role in formation of a stable hemostatic white thrombus and a major role in the blood-clotting process. It has also been suggested that platelets are important in many of the reactions in the intrinsic pathway of coagulation. Recent evidence emphasizes the pivotal role of abnormal platelet function in acute coronary artery diseases, myocardial infarction, unstable angina and stroke. Acute exercise might be harmful for inactive individuals and particularly patients, if the exercise intensity is high. One of the main mechanisms causing this, is exercise-induced thrombosis. On the other hand, regular exercise or exercise training results in health benefits and improvements in lifestyle not only in normal healthy subjects but also in patients. However, the study of exercise training effects on blood platelets are highly contentious because of the fact that the analytical methods employed to study platelets are different and accompanied by numerous methodological problems. Few studies are available on the effect of training on blood platelets and the exact effects of exercise training on platelet activation and function is not as yet known. This lack of information makes further studies particularly important, in order to clarify whether there are favorable effects of exercise training on platelet aggregation and function in health and disease. This article presents a summary of the previous research findings that investigated the interaction between acute and chronic exercise and platelets in health and disease, as well as providing directions for future studies.

Keywords

Main Subjects

References

  1. Cardigan R, Turner C, Harrison P. Current methods of assessing platelet function: relevance to transfusion medicine. Vox Sang. 2005;88(3):153-63.
  2. Aldemir H, Kiliç N. The effect of time of day and exercise on platelet functions and platelet–neutrophil aggregates in healthy male subjects. Mol Cell Biochem. 2005;280(1-2):119-24.
  3. Ahmadizad S, El-Sayed MS. The effects of graded resistance exercise on platelet aggregation and activation. Med Sci Sports Exerc. 2003;35(6):1026-32.
  4. Blair P, Flaumenhaft R. Platelet α-granules: Basic biology and clinical correlates. Blood Rev. 2009;23(4):177-89.
  5. Kaplan JE, Saba TM. Platelet removal from the circulation by the liver and spleen. Am J Physiol Heart Circ. 1978;235(3):H314-H320.
  6. Kuter DJ. The physiology of platelet production. Stem Cells. 1996;14(S1):88-101.
  7. White JG, Michelson A. Platelet structure. Platelets. 2007;2:45-71.
  8. Bussel JB, Kunicki TJ, Michelson AD. Platelets: New understanding of platelet glycoproteins and their role in disease. ASH. 2000;2000(1):222-40.
  9. Maree AO, Fitzgerald DJ. Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. Circulation. 2007;115(16):2196-207.
  10. Stalker TJ, Newman DK, Peisong Ma, Wannemacher KM, Brass LF. Platelet signaling. In: Antiplatelet Agents. Philadelphia: Springer; 2012. p. 59-85.
  11. Gibbins JM. Platelet adhesion signalling and the regulation of thrombus formation. J Cell Sci. 2004;117(16):3415-25.
  12. White JG. Electron microscopy methods for studying platelet structure and function. New: Jersey: Humana Press; 2004; p. 47-63.
  13. Parise LV, Smyth SS, Coller BS. Platelet morphology, biochemistry and function. Williams hematology. 2001;7:1597-645.
  14. Ghoshal K, Bhattacharyya M. Overview of platelet physiology: Its hemostatic and nonhemostatic role in disease pathogenesis. Sci World J. 2014;20(4):1-16.
  15. Weber AA, Heim HK, Schumacher M, Schrör K, Hohlfeld T. Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers. Platelets. 2007;18(5):379-85.
  16. De Meirelles L, Mendes‐Ribeiro A, Mendes M, Da Silva M, John Clive Ellory J, Mann G, et al. Chronic exercise reduces platelet activation in hypertension: Upregulation of the l‐arginine‐nitric oxide pathway. Scand J Med Sci Sports 2009;19(1):67-74.
  17. El-Sayed MS, Ali N, Ali Zes. Aggregation and activation of blood platelets in exercise and training. Sports Med. 2005;35(1):11-22.
  18. Davì G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007;357(24):2482-94.
  19. Michelson AD. Thrombin-induced down-regulation of the platelet membrane glycoprotein Ib-IX complex. In: Seminars in thrombosis and hemostasis. Vol. 18. Worcester: Thieme Medical Publishers, Inc; 1992. p. 18-27.
  20. Ahmadizad S, Cheragi Far S, Ebarhim K, Rahmani H, Taghizadeh MR. Response of platelet indices to concentric and eccentric isokinetic‌ contractions in men. Sci J Rehabil Med. 2016;7(2): 188-96.
  21. David T, Ohlmann P, Eckly A, Moog S, Cazenave JP, Gachet C, et al. Inhibition of adhesive and signaling functions of the platelet GPIb‐V‐IX complex by a cell penetrating GPIbα peptide. J Thromb Haemost. 2006;4(12):2645-55.
  22. Ikarugi H, Taka T, Nakajima S, Noguchi T, Watanabe S, Sasaki Y, et al. Norepinephrine, but not epinephrine, enhances platelet reactivity and coagulation after exercise in humans. J Appl Physiol. 1999;86(1):133-8.
  23. Wang JS, Jen CJ, Kung H, Lin LJ, Hsiue TR, Chen H. Different effects of strenuous exercise and moderate exercise on platelet function in men. Circulation. 1994;90(6):2877-85.
  24. Tozzi-Ciancarelli M, Penco M, Di Massimo C. Influence of acute exercise on human platelet responsiveness: possible involvement of exercise-induced oxidative stress. Eur J Appl Physiol. 2002;86(3):266-72.
  25. Wang JS, Liao CH. Moderate-intensity exercise suppresses platelet activation and polymorphonuclear leukocyte interaction with surface-adherent platelets under shear flow in men. Thromb Haemostasis. 2004;91(3):587-94.
  26. Bourey RE, Santoro SA. Interactions of exercise, coagulation, platelets, and fibrinolysis—a brief review. Med Sci Sports Exerc. 1988;20(5):439-46.
  27. El-Sayed MS, Sale C, Jones P, Chester M. Blood hemostasis in exercise and training. Med Sci Sports Exerc. 2000;32(5):918-25.
  28. El-Sayed MS. Exercise and training effects on platelets in health and disease. Platelets. 2002;13(5-6):261-6.
  29. El-Sayed MS. Effects of alcohol ingestion post-exercise on platelet aggregation. Thromb Res. 2002;105(2):147-51.
  30. Ahmadizad S, Nouri-Habashi A, Rahmani H, Maleki M, Naderi N, Lotfian S, et al. Platelet activation and function in response to high intensity interval exercise and moderate continuous exercise in CABG and PCI patients. Clin Hemorheol Microcirc. 2016;64(4):911-9.
  31. Ghaediyan S, Marefati H, Nabipur F, Naghizadeh M. The effect of a moderate aerobic exercise on the blood coagulation markers in young non-athlete females. J Jah Uni Med Sci. 2012;10(2): 10(2):65-72
  32. El-Sayed MS, Ali ZS, Ahmadizad S. Exercise and training effects on blood haemostasis in health and disease: an update. Sports med. 2004;34(3):181-201.
  33. Herren T, Bartsch P, Haeberli A, Straub PW, Increased thrombin-antithrombin III complexes after 1 h of physical exercise. J appl physiol. 1992;73(6):2499-2504.
  34. Wang JS, Cheng LJ. Effect of strenuous, acute exercise on α2-adrenergic agonist–potentiated platelet activation. Arterioscler Thromb Vasc Biol. 1999;19(6):1559-65.
  35. Bärtsch P, Haeberli A, Straub P. Blood coagulation after long distance running: antithrombin III prevents fibrin formation. Thromb haemostasis. 1990;63(3):430-4.
  36. Robach P, Boisson RC, Vincent L, Lundby C, Moutereau S, Gergele L, et al. Hemolysis induced by an extreme mountain ultra‐marathon is not associated with a decrease in total red blood cell volume. Scand J Med Sci Sports. 2014;24(1):18-27.
  37. Ahmadizad S, El-Sayed MS. The acute effects of resistance exercise on the main determinants of blood rheology. J Sports Sci. 2005;23(3):243-9.
  38. Michelson AD, Barnard MR, Hechtman HB, MacGregor H, Connolly RJ, Loscalzo J, et al. Vivo tracking of platelets: Circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function. Proc Natl Acad Sci. 1996;93(21):11877-82.
  39. Li N, He S, Blombäck M, Hjemdahl P. Platelet activity, coagulation, and fibrinolysis during exercise in healthy males. Arterioscl Throm Vas. 2007;27(2):407-13.
  40. Coppola A, Coppola L, dalla Mora L, Limongelli FM, Grassia A, Mastrolorenzo L, et al. Vigorous exercise acutely changes platelet and B-lymphocyte CD39 expression. J appl physiol. 2005;98(4):1414-9.
  41. Rezaeimanesh D, Ahmadizad S, Ebrahim K. The reactions of platelet indexes to a simulated session of soccer activity in professional players. Med J Mash Uni Med Sci. 2015;58(5):243-51.
  42. Hanke A, Staib A, Görlinger K, Perrey M, Dirkmann D, Kienbaum P. Whole blood coagulation and platelet activation in the athlete: A comparison of marathon, triathlon and long-distance running. Crit Care J. 2008; 15(2):59-65.
  43. Watts E. Haemostatic changes in long-distance runners and their relevance to the prevention of ischaemic heart disease. Blood Coagul Fibrinolysis. 1991;2(2):221-6.
  44. Knudsen JB, Brodthagen U, Gormsen J, Jordal R, Nørregaard‐Hansen K, Paulev PE. Platelet function and fibrinolytic activity following distance running. Scan j haematol. 1982;29(5):425-30.
  45. Möckel M, Ulrich N, Heller G, Röcker Jr L, Hansen R, Riess H, et al. Platelet activation through triathlon competition in ultra-endurance trained athletes: Impact of thrombin and plasmin generation and catecholamine release. Int J Sports Med. 2001;22(5):337-43.
  46. Sakita SY, Kishi Y, Numano F. Acute vigorous exercise attenuates sensitivity of platelets to nitric oxide. Thromb res. 1997;87(5):461-71.
  47. Gawel M, Glover V, Burkitt M, Sandler M, Rose FC. The specific activity of platelet monoamine oxidase varies with platelet count during severe exercise and noradrenaline infusion. Psychopharmacology. 1981;72(3):275-7.
  48. Haber P, Silberbauer K, Sinzinger H. Quantitative studies on reversible thrombocyte aggregation during exertion. Schweizerische Medizinische Wochenschrift. 1980;110(41):1488-91.
  49. Menzel K, Hilberg T. Blood coagulation and fibrinolysis in healthy, untrained subjects: effects of different exercise intensities controlled by individual anaerobic threshold. Eur J Appl Physiol. 2011;111(2):253-60.
  50. Hilberg T, Menzel K, Gläser D, Zimmermann S, Gabriel HHW. Exercise intensity: Platelet function and platelet–leukocyte conjugate formation in untrained subjects. Thromb Res. 2008;122(1):77-84.
  51. Cohen R, Epstein S, Cohen L, Dennis L. Alterations of fibrinolysis and blood coagulation induced by exercise, and the role of beta-adrenergic-receptor stimulation. The Lancet. 1968;292(7581):1264-6.
  52. Peters A. Just how big is the pulmonary granulocyte pool? Clin Sci (Lond). 1998;94(1):7-19.
  53. Walsh JH, Bilsborough W, Maiorana A, Best M, O'Driscoll GJ, Taylor RR, et al. Exercise training improves conduit vessel function in patients with coronary artery disease. J Appl Physiol. 2003;95(1):20-5.
  54. Williams MA, Haskell WL, Ades PA, Amsterdam EA, Bittner V, Franklin BA, et al. Resistance exercise in individuals with and without cardiovascular disease: 2007 update. Circulation. 2007;116(5):572-84.
  55. Azimpour, M. and A. Shahdadi, Response of Coagulation Indices to Two Types of Exercise of Eccentric and Isometric in Male Bodybuilding Athletes. Qom Uni Med Sci J 2016. 10,(2): p. 12-21.
  56. Ahmadizad, S., M.S. El-Sayed, and D.P. MacLaren, Responses of platelet activation and function to a single bout of resistance exercise and recovery. Clin Hemorheol Microcirc. 2006. 35(1, 2): p. 159-168.
  57. Smith, L., A. Anwar, M. Fragen, C. Rananto, R. Johnson, and D. Holbert, Cytokines and cell adhesion molecules associated with high-intensity eccentric exercise. Eur J Appl Physiol. 2000. 82(1-2): p. 61-67.
  58. Röcker, L., S. Günay, H.-C. Gunga, W. Hopfenmüller, A. Ruf, H. Patscheke, et al., Activation of blood platelets in response to maximal isometric exercise of the dominant arm. Int. J. Sports Med. 2000;21(03): p. 191-194.
  59. Creighton, B.C., The Influence of Resistance Training on Primary Hemostatic Responses. Eur J Appl Physiol. 2013;113(9):2203-9.
  60. de Oliveira Teixeira A, Franco OS, Borges MM, Noronha Martins C, Fernando Guerreiro L, da Rosa CF, et al. The importance of adjustments for changes in plasma volume in the interpretation of hematological and inflammatory responses after resistance exercise. J Exerc Physiol Online. 2014;17(4): 72-83.
  61. Ahmadizad S, El-Sayed MS, MacLaren DP. Effects of time of day and acute resistance exercise on platelet activation and function. Clin Hemorheol Microcirc. 2010;45(2-4):391-9.
  62. Haynes A, Linden MD, Robey E, Watts GF, Barrett H, Naylor LH, et al. Impact of commonly prescribed exercise interventions on platelet activation in physically inactive and overweight men. Physiol Rep. 2016;4(20):e12951.
  63. Wang JS, Jen CJ, Chen HI. Effects of exercise training and deconditioning on platelet function in men. Arterioscl Throm Vas Biol. 1995;15(10):1668-74.
  64. Tabet JY, Meurin P, Driss AB, Weber H, Renaud N, Grosdemouge A, et al. Benefits of exercise training in chronic heart failure. Arch Cardiovasc Dis. 2009;102(10):721-30.
  65. Heber S, Volf I. Effects of physical (in) activity on platelet function. BioMed Res int. 2015;20(1):1-11.
  66. Lehmann M, Hasler K, Bergdolt E, Keul J. Alpha-2-adrenoreceptor density on intact platelets and adrenaline-induced platelet aggregation in endurance-and nonendurance-trained subjects. Int J Sports Med. 1986;7(03):172-6.
  67. Heber S, Assinger A, Pokan R, Volf I. Correlation between cardiorespiratory fitness and platelet function in healthy women. Med Sci Sports Exerc. 2016;48(6):1101-10.
  68. Podgórska K, Derkacz A, Szahidewicz-Krupska E, Jasiczek J, Dobrowolski P, Radziwon-Balicka A, et al. Effect of regular aerobic activity in young healthy athletes on profile of endothelial function and platelet activity. BioMed Res Int. 2017; 87 (15):1-9.
  69. Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 1994;74(2):349-53.
  70. Wang JS, Lin CC, Chen JK, Wong MK. Role of chronic exercise in decreasing oxidized LDL-potentiated platelet activation by enhancing platelet-derived no release and bioactivity in rats. Life Sci. 2000;66(20):1937-48.
  71. Wang, JS, Li YS, Chen JC, Chen YW. Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men. Arterioscler Thromb Vasc Biol. 2005;25(2):454-60.
  72. Wang JS, Jen CJ, Chen HI. Effects of chronic exercise and deconditioning on platelet function in women. J Appl Physiol. 1997;83(6):2080-5.
  73. Kaul S, Makkar RR, Nakamura M, Litvack FI, Shah PK, Forrester JS, et al. Inhibition of acute stent thrombosis under high-shear flow conditions by a nitric oxide donor, DMHD/NO. Circulation. 1996. 94(9): p. 2228-2234.
  74. Chen H, Chiang IP. Chronic exercise decreases adrenergic agonist-induced vasoconstriction in spontaneously hypertensive rats. Am J Physiol Heart Circ. 1996;271(3):H977-H983.
  75. Ficicilar H, Zergeroglu A, Ersoz G, Erdogan A. The effects of short-term training on platelet functions and total antioxidant capacity in rats. Physiol Res. 2006;55(2): 151-6
  76. Wang JS, Yang CF, Wong MK, Chow SE, Chen JK. Effect of strenuous arm exercise on oxidized-LDL-potentiated platelet activation in individuals with spinal cord injury. Thromb haemostasis. 2000;84(1):118-23.
  77. Ruslan NH, Ghosh AK, Hassan R. A comparative study on platelet activation markers between continuous and intermittent exercise training programs in healthy males. J Hematol. 2014;3(3):72-5.
  78. Gielen S, Schuler G, Hambrecht R. Exercise training in coronary artery disease and coronary vasomotion. Circulation. 2001;103(1):e1-e6.
  79. Gonzales F, Manas M, Seiquer I, Quiles J, Mataix F, Huertas J, et al. Blood platelet function in healthy individuals of different ages. Effects of exercise and exercise conditioning. J Sport Med Phys Fit. 1996;36(2):112-6.
  80. Kestin AS, Ellis PA, Barnard MR, Errichetti A, Rosner BA, Michelson AD. Effect of strenuous exercise on platelet activation state and reactivity. Circulation. 1993;88(4):1502-11.
  81. Sossdorf M, Otto GP, Claus RA, Gabriel HH, Losche W. Cell-derived microparticles promote coagulation after moderate exercise. Med Sci Sports Exerc. 2011;43(7):1169-76.
  82. Rezaeimanesh D, Ahmadizad S, Ebarhim K. The effect of preparation periods and matches on the rest levels of platelet indexes, fibrinogen and CRP index in soccer professional players. Sport Physiol. 2016;8(31):135-52. (In Persian).
  83. Chen YW, Chen YC, Wang JS. Absolute hypoxic exercise training enhances in vitro thrombin generation by increasing procoagulant platelet-derived microparticles under high shear stress in sedentary men. Clin Sci. 2013;124(10):639-49.
  84. El-Sayed MS, Younesian A, Rahman K, Ismail FM, Ali ZS. The effects of arm cranking exercise and training on platelet aggregation in male spinal cord individuals. Thromb Res. 2004;113(2):129-36.
  85. Rauramaa R, Salonen JT, Seppänen K, Salonen R, Venäläinen J, Ihanainen M, et al. Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men. Circulation. 1986;74(5):939-44.
  86. Amouzade Mahdiraji H, Mojtaba M, Fadaei S. Comparison of the effect of four weeks of resistance and aerobic training on coagulation and fibrinolytic factors in passive elderly men. Med J Mash Uni Med Sci. 2013;56(3):150-8.
  87. Amini A, Kordi M, Gaeini A, Ahmadi A, Vesi K. The effect of resistance training on coagulation and fibrinolytic factors in passive elderly men. Quar Ofogh Dan. 2012;18(3):104-8.
  88. Hulmi JJ, Myllymäki T, Tenhumäki M, Mutanen N, Puurtinen R, Paulsen G, et al. Effects of resistance exercise and protein ingestion on blood leukocytes and platelets in young and older men. Eur J Appli Physiol. 2010;109(2):343-53.
  89. Boknäs N, Ramström S, Faxälv L, Lindahl TL. Flow cytometry-based platelet function testing is predictive of symptom burden in a cohort of bleeders. Platelets. 2017; 29(5):512-19
Sport Physiology
Volume 11, Issue 43
Fall 2018
October 2019
Pages 17-38

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History

  • Receive Date: 08 July 2017
  • Revise Date: 20 November 2017
  • Accept Date: 19 December 2017

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