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Exercise and Training Effects on Platelet Activation and Function: A Review Article

Document Type : Review Article

Authors

1 Associate Professor of Exercise Physiology, Shahid Beheshti University

2 Ph.D. Student in Exercise Physiology, Shahid Beheshti University

3 Post-Doctoral Researcher in Exercise Physiology, Shahid Beheshti University

Abstract

Platelets play an important role in formation of a stable hemostatic white thrombus and a major role in the blood-clotting process. It has also been suggested that platelets are important in many of the reactions in the intrinsic pathway of coagulation. Recent evidence emphasizes the pivotal role of abnormal platelet function in acute coronary artery diseases, myocardial infarction, unstable angina and stroke. Acute exercise might be harmful for inactive individuals and particularly patients, if the exercise intensity is high. One of the main mechanisms causing this, is exercise-induced thrombosis. On the other hand, regular exercise or exercise training results in health benefits and improvements in lifestyle not only in normal healthy subjects but also in patients. However, the study of exercise training effects on blood platelets are highly contentious because of the fact that the analytical methods employed to study platelets are different and accompanied by numerous methodological problems. Few studies are available on the effect of training on blood platelets and the exact effects of exercise training on platelet activation and function is not as yet known. This lack of information makes further studies particularly important, in order to clarify whether there are favorable effects of exercise training on platelet aggregation and function in health and disease. This article presents a summary of the previous research findings that investigated the interaction between acute and chronic exercise and platelets in health and disease, as well as providing directions for future studies.

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References
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Sport Physiology
Volume 11, Issue 43
Fall 2018
October 2019
Pages 17-38
Files
History
  • Receive Date: 08 July 2017
  • Revise Date: 20 November 2017
  • Accept Date: 19 December 2017
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