The effect of exercise on beige adipose tissue

Obesity leads to metabolic diseases, and adipose tissue considered as one of the regulator of metabolism. Recent researches has demonstrated that some stimulants cause beiging of subcutaneous adipose tissue, resulting in thermogenesis and some other features of brown adipose tissue. The activation of β3-adrenergic receptors in the adipose tissue that occurs as a result of exercise also leads to the activation of UCP1 and is one of the most effective methods to combat obesity. Becacuse exercise is known as a cheap lifestyle intervention and the benefits of using it as a non-pharmocological treaetment in improvement of metabolic diseases, including obesity, have been well illustrated, Examining the molecular mechanisms of exercise is essential. One of these molecular mechanisms is the increase in thermogenesis due to exercise, which can be caused by the release of various types of cytokines. Due to the physical activity of the UCP1, it increases as the beige process occurs in the subcutaneus white adipose tissues. Increase in various cytokines and important genes involved in this process, which occur with different types of exercises at various levels, is a promise that exercises could be considered as one of the possible treatments for obesity and metabolic syndrome.