Document Type : Research Paper
Authors
1 Ph.D. Student of Exercise Physiology, University of Tabriz, Tabriz, Iran
2 Associated Professor of Exercise Physiology, University of Tabriz, Tabriz, Iran
Abstract
The aim of this study was to determine the effect of six weeks high intensity interval training (HIIT) with turmeric supplementation on visceral fat, subcutaneous abdominal fat and insulin resistance in obese females. Thirty obese women aged 20-25 years in quasi-experimental study with pre-post testing design, were selected purposefully and were randomly divided into two homogeneous groups of 15 participants: HIIT & placebo, and HIIT & Turmeric supplement (3 milligram curcumin per kilogram body weight per day). Preparation period performed for 3 weeks and HIIT performed for 6 weeks and 4 sessions per week. Blood samples were taken in two phases, before and 48 hours after last exercise session in the follicular phase. Abdominal fat was measured by ultrasound system. Serum insulin and glucose were measured by enzyme immunoassay and photometric method respectively. The data were analyzed at α
Keywords
- Tabatabaei O, Larijani B. A review of the prevalence of obesity and its management in Iran. Iran J Diabetes and Metab. 2013;12(5):357-74. (In Presian).
- Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M .A systematic review of anti-obesity medicinal plants-an update. J Diabetes Metab Disord. 2013;12(28(:1-10.
- Mutsert R, Gast K, Widya R, Koning E, Jazet I, Lamb H, et al. Associations of abdominal subcutaneous and visceral fat with insulin resistance and secretion differ between men and women: The etherlands epidemiology of obesity study. Metab Syndr Relat Disord.. 2018;16(1):1-10.
- Afshari S, Kordi M.R, Mohammad-Amoli M, Daneshyar S. The effect of high intensity interval training (HIIT) on gene expression of uncoupling protein 1 (UCP-1) in subcutaneous white adipose tissue of wistar rats. Sport Physiol. 2018;10(39):17-32. (In Presian).
- Boutcher SH. High-intensity intermittent exercise and fat loss. J Obes. 2011; 2011: 1-10.
- Alahmadi AM. High-intensity interval training and obesity. J Nov Physiother. 2014;4(3(:1-6.
- Heydari M, Freund J, Boutcher SH. The effect of high-intensity intermittent exercise on body composition of overweight young males. J Obes 2012; 2012:1-8.
- Skleryk JR, Karagounis LG, Hawley JA, Sharman MJ, Laursen PB, et al. Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men. Diabetes, Obes. Metab. 2013; 15:1146-53.
- Zhang H, Tong TK, Qiu W, Wang J, Nie J, He Y. Effect of high intensity interval training protocol on abdominal fat reduction in overweight chinese women. Kinesiology. 2015;47(1):57-66.
- LaForgia J, Withers RT, Gore CJ. Effects of exercise intensity and duration on the excess post-exercise oxygen consumption. J Sport Sci. 2006;24(12):1247-64.
- Stenman M. Effects of high-intensity interval training on VO2max and post-exercise fat consumption in recreationally active adults compared to steady-state running [Master’s thesis]. [City of Jyväskylä]: University of Jyväskylä; 2016.
- Almenning I, Rieber-Mohn A, Lundgren KM, Shetelig Lovvik T, Garnaes K, Moholdt T. Effects of high intensity interval training and strength training on metabolic, cardiovascular and hormonal outcomes in women with polycystic ovary syndrome: A pilot study. PLoS One. 2015;10(9): e0138793.
- Logan GR, Harris N, Duncan S, Plank LD, Merien F, Schofield G. Low-active male adolescents: A dose response to high-intensity interval training. Med Sci Sports Exercise. 2016;48(3):481-90.
- Meydani M, Hasan ST. Dietary polyphenols and obesity. Nutrients. 2010;2(7): 737-51.
- Shehzad A, Ha T, Subhan F, Lee Y. S. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr. 2011;50(3):151-61.
- Wickenberg J, Ingemansson S. L, Hlebowicz J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J. 2010;9(43(: 1-5.
- Shao W, Yu Z, Chiang Y,Yang Y, Chai T, Foltz W, Lu H, Fantus I. G, Jin T. Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS One. 2012;7(1): e28784.
- Di pierro F, Bressan A, Ranaldi D, G. Rapacioli, Giacomelli L, Bertuccioli A. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome: Preliminary study. Riv Eur Sci Med Farmacol. 2015;19: 4195-202.
- Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai S. Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract a randomized controlled trial. J Nutr Biochem. 2014;25:144–50.
- Ribeiro-Filho FF, Faria A, Azjen S, Zanella MT, Ferreira SRG. Methods of estimation of visceral fat: Advantages of ultrasonography. Obes Res. 2003;11(12):1488-94.
- FAO/WHO. Evaluatin of certain food additives and contaminants. Sixty-first meeting of the Joint FAO/WHO Expert Committee on Food Addtives. WHO Technical Report Series 922; 2004.
- Whyte LJ, Ferguson C, Wilson J, Scott RA, Gill JM. Effects of single bout of very high-intensity exercise on metabolic health biomarkers in overweight/obese sedentary men. Metabolism. 2013;62(2):212-9.
- Little JP, Safdar A, Bishop D, Tarnopolsky MA, Gibala MJ.An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1alpha and activates mitochondrial biogenesis in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2011;300(6):R1303-10.
- Ray Hamidie, R. D. Yamada, T. Ishizawa, R. Saito, Y. Masuda, K. Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels. Metabolism .2015;64(10): 1334-47.
- Su H, Jiang ZH, CaoG, WenT, ShaoJ, Li L. Effects of HIITand MICT for 10 weeks on myocardial AMPK and PGC-1α in rats. Exercise Biochem Rev. 2018; 1(2): 23-5.
- Lee CH, Kim AU, Pyun CW, Fukushima M, Han KH.Turmeric (curcuma longa) whole powder reduces accumulation of visceral fat mass and increases hepatic oxidative stress in rats fed a high-fat diet. Food Science and Biotechnology. 2014;23(1):261-7.
- Pahl J. Curcumin use in the attenuation of diet-induced metabolic syndrome in rats [Bachelor’ thesis]. [Queensland]: University of Southern Queensland Toowoomba; 2016
- Lone J, Choi JH, Kim SW, Yun JW. Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes. J Nutr Biochem. 2016;27:193-202.
- Maillard F, Pereira B, Boisseau N. Effect of high-intensity interval training on total, abdominal and visceral fat mass: A meta-analysis. Sports Med. 2017; DOI 10.1007/s40279-017-0807-y.
- Naijil G, Anju TR, Jayanarayanan S, Paulose CS. Curcumin pretreatment mediates antidiabetogenesis via functional regulation of adrenergic receptor subtypes in the pancreas of multiple low-dose streptozotocin-induced diabetic rats. Nutr Res. 2015;35:823-33.
- Dewar AM, Clark RA, Singer AJ, Frame MD. Curcumin mediates both dilation and constriction of peripheral arterioles via adrenergic receptors. J Invest Dermatol. 2011;131: 1754–60.
- Khodadadi H, Rajabi H, Attarzadeh SR, Abbasian S. The effect of high intensity interval training (HIIT) and pilates on levels of irisin and insulin resistance in overweight women. Iran J Endocrin Metab. 2014;16(3):190-6. (In Persian).
- Cassidy S, Thoma C, Houghton D, Trenell M I. High-intensity interval training: a review of its impact on glucose control and cardiometabolic healt. Diabetologia. 2017;60: 7–23.
- He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, inflammation, and chronic diseases: How are they linked? Molecules. 2015;20(5):9183-213.
- Jimenez-Osorio AS, Monroy A, Alavez S. Curcumin and insulin resistance Molecular targets and clinical evidences. BioFactors. 2016;42(6):561–80.
- Sahin K, Pala R, Tuzcu M, Ozdemir O, Orhan C, Sahin N, Juturu V. Curcumin prevents muscle damage by regulating NF-kappaB and Nrf2 pathways and improves performance: an in vivo model. J Inflammation Res. 2016;9:147-54.