Effect of 6 Weeks High Intensity Interval Training on Selected Factors of Cardiac Angiogenesis in Rats with Myocardial Infarction

Document Type : Research Paper

Authors
Sara Karbalaeifar 1
Abbas Ali Gaeini 2
Mohammad Reza Kordi 3
Reza Nuri 4
Pedram Ghorbani 1
1 Ph.D. Student of Exercise Physiology, Tehran University, Kish International Campus, Kish, Iran
2 Professor of Exercise Physiology, Tehran University, Tehran, Iran
3 Associate Professor of Exercise Physiology, Tehran University, Tehran, Iran
4 Assistant Professor of Exercise Physiology, Tehran University, Kish International Campus, Kish, Iran
10.22089/spj.2019.2676.1359
Abstract
Myocardial infarction (MI) is cell death in part of the myocardial during an Ischemia. Cell process in response to activity and appropriate intensity is not clear yet. Therefore, this research done to evaluate the effect of 6 weeks high intensity interval training (HIIT) on expression of VEGF, COL-18 and their common receptor (Flt-1) genes. For this purpose, 12 Wistar male rats with 10 weeks old and average weight 250-300 gr that infected to myocardial infarction and they were designed in to two groups of experimental (60 minutes of interval running on treadmills that each interval is 4 minutes with the 85-90 percent of Vo2max and 2 minutes of active rest at 50-60 percent of Vo2max for four days in a week and during a period of 6 weeks) and control group (without any training) . Genes expression was investigated by the PCR technique and data were analyzed by the SPSS 18 with T test (α≤0.05). The findings of present study showed that the amount of VEGF in HIIT (6.397 mg/ml) is significantly much more than the control group (1.002 mg/ml) (P=0.001) and the amount of Flt-1 in HIIT group (8.927 mg/ml) was also significantly much more than control group (1.380 mg/ml) (P≤0.001) . and the amount of COL-18 in HIIT group (1.724 mg/ml) was not significantly more than control group (1.265 mg/ml) (P≤0.340). In general, 6 weeks of HIIT can effective on angiogenesis factors after MI in male Wistar rats.
Keywords
Angiogenesis
Myocardial Infarction
High Intensity Interval Training

Main Subjects

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Sport Physiology
Volume 11, Issue 42 - Serial Number 42
Summer 2019
August 2019
Pages 17-30

  • Receive Date 17 June 2016
  • Revise Date 30 October 2016
  • Accept Date 06 November 2016