The Effect of 8 Weeks of Resistance and Aerobic Interval Training on Levels of GLP-1, NRG-1 and IL-33 in Type 2 Diabetic Women

Document Type : Research Paper

Authors

1 Ph.D. Student of Exercise Physiology, Urmia University

2 Associate Professor of Exercise Physiology, Urmia University

3 Assistant Professor of Exercise Physiology, Urmia University

Abstract

Considering the importance of glycemic balance adjustment in preventing cardiovascular complications of diabetes mellitus, regulation and control of blood glucose and insulin resistance is a very important issue. Including the protective factors that contrast with high blood glucose damage, can interoduce glucagon-like peptides (GLP-1), Neuregulin-1 (NRG-1), and interleukin-33 (IL-33) that this factor can be affected by exercise. Therefore, the purpose of this study was to investigate the effect of 8 weeks of resistance and aerobic interval training on levels of GLP-1, NRG-1 and IL-33 in type 2 diabetic women. 30 diabetic women (51.9 ± 5.9 years) were randomly devided into 3 groups (n=10 in each group), resistance training, aerobic interval training and volunteer control. Aerobic interval training was performed with intensity of 50-75% MHR and resistance training performed with intensity of 30-75% 1RM, 3 sessions per week for 8 weeks. The values of GLP-1, NRG-1 and IL-33 were measured by ELISA kit. For data, analysis used ANCOVA (P<0.05). The results of this study showed that resistance training compared to control group significantly increased (P = 0.007) the GLP-1. Aerobic (P = 0.037) and resistance training (P = 0.001) compared to the control group and resistance training compared to aerobic training (P = 0.008) significantly increased IL-33. NRG-1 changes were not significant in the two training groups. It seems that resistance training with positive regulation of GLP-1 and IL-33 has a better effect on glycemic control, blood glucose and ultimately improving cardiovascular conditions in type 2 diabetic women.

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Main Subjects

References

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Sport Physiology
Volume 12, Issue 46
July 2020
Pages 117-138

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History

  • Receive Date: 11 May 2019
  • Revise Date: 11 September 2019
  • Accept Date: 21 September 2019

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