The Effect of 8 Weeks of Resistance and Aerobic Interval Training on Levels of GLP-1, NRG-1 and IL-33 in Type 2 Diabetic Women

Document Type : Research Paper

Authors
Ebrahim Froozandeh 1
Asghar Tofighi 2
Javad Tolouei Azar 3
1 Ph.D. Student of Exercise Physiology, Urmia University
2 Associate Professor of Exercise Physiology, Urmia University
3 Assistant Professor of Exercise Physiology, Urmia University
10.22089/spj.2019.7434.1913
Abstract
Considering the importance of glycemic balance adjustment in preventing cardiovascular complications of diabetes mellitus, regulation and control of blood glucose and insulin resistance is a very important issue. Including the protective factors that contrast with high blood glucose damage, can interoduce glucagon-like peptides (GLP-1), Neuregulin-1 (NRG-1), and interleukin-33 (IL-33) that this factor can be affected by exercise. Therefore, the purpose of this study was to investigate the effect of 8 weeks of resistance and aerobic interval training on levels of GLP-1, NRG-1 and IL-33 in type 2 diabetic women. 30 diabetic women (51.9 ± 5.9 years) were randomly devided into 3 groups (n=10 in each group), resistance training, aerobic interval training and volunteer control. Aerobic interval training was performed with intensity of 50-75% MHR and resistance training performed with intensity of 30-75% 1RM, 3 sessions per week for 8 weeks. The values of GLP-1, NRG-1 and IL-33 were measured by ELISA kit. For data, analysis used ANCOVA (P<0.05). The results of this study showed that resistance training compared to control group significantly increased (P = 0.007) the GLP-1. Aerobic (P = 0.037) and resistance training (P = 0.001) compared to the control group and resistance training compared to aerobic training (P = 0.008) significantly increased IL-33. NRG-1 changes were not significant in the two training groups. It seems that resistance training with positive regulation of GLP-1 and IL-33 has a better effect on glycemic control, blood glucose and ultimately improving cardiovascular conditions in type 2 diabetic women.
Keywords
Diabetes
Aerobic Interval Training
Resistance Training
Insulin Resistance
NRG-1
GLP-1
IL-33

Main Subjects

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Sport Physiology
Volume 12, Issue 46
July 2020
Pages 117-138

  • Receive Date 11 May 2019
  • Revise Date 11 September 2019
  • Accept Date 21 September 2019