The Effect of Exercise Cognitive Preconditioning on Ntrk2, Bcl2/Bax Ratio Gene Expression and Complications of Stroke

Document Type : Research Paper

Authors

1 Ph.D. Student in Exercise Physiology, Shahid Rajaee Teacher Training University, Tehran

2 Associate Professor of Exercise Physiology, Shahid Rajaee Teacher Training University, Tehran

3 Associate Professor of Physiology, North Khorasan University of Medical Sciences, Bojnourd

Abstract

One valuable approach for increasing health and reducing brain damage is to do exercise and Cognitive Activity. The aim of the present study was to determine the effect of exercise cognitive preconditioning on the factors of stroke.  In this study, 30 Wistar rats (eight weeks old and weighing 200 to 250 g) were randomly divided into three groups: Cognitive exercise + ischemia, control (healthy, without exercise intervention) and ischemia. The exercise consisted of swimming in the Morris Water Maze for three weeks, three days per week, and four times per day for 10 minutes. After the last training session, rats underwent global ischemia.  Real-time PCR was used to measure Ntrk2 and Bcl2/Bax genes expression and they were analyzed using one-way ANOVA analysis of variance and Benfroni post hoc test. Results showed a significant increase in Ntrk2 gene expression in Cognitive exercise + ischemia group compared to control and ischemic groups (P≤0.05). Also, the expression of Bcl2/Bax gene in the control group was significantly higher than the two groups of cognitive exercise + ischemia and ischemia (P≥0.05). Neurological and sensory-motor dysfunction scores were significantly decreased in the Cognitive exercise + ischemia group compared to the control and ischemia groups (P≤0.05). Exercise cognitive preconditioning seems to be able to increase Ntrk2, Bcl2/Bax genes expression and decrease the score of neurological and sensory-motor impairment in the stroke process.

Keywords

Main Subjects

References

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Sport Physiology
Volume 11, Issue 44
Winter 2020
February 2020
Pages 143-160

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History

  • Receive Date: 27 October 2019
  • Revise Date: 11 April 2020
  • Accept Date: 19 April 2020

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