Document Type : Research Paper
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Abstract
The present study was investigated the effects of two aerobic exercise intensities on lipocalin-2 (Lcn2), interleukin-1 beta (IL-1β) and insulin resistance index (HOMA-IR) in 27 sedentary obese men (aged: 43.9 ± 5 yrs, BMI: 31.8±1.5; mean±SD and VO2max: 31.8±1.8) that have been selected randomly among volunteers. The participants divided into three equal groups: moderate intensity (45-55% Vo2max); high intensity (65-75% Vo2max); and untrained control group. Participants in both exercise training groups were completed a 12 weeks treadmill running (45 min/session; 3 d/week). The ANOVA test showed a significant decrease of serum Lcn2 (53.1±11.2 to 43.5±8.1 µg/L) in moderate intensity (52.2±10.3 to 47.5±8.5 µg/L) and detrained groups (54.1±9.7 to 53.2±11.9 µg/L) than baseline. This decrease was significantly different with other groups (p<0.05). Also, there was not any change in high intensity group after exercise than baseline. Indeed, a significant decrease was observed in IL-1β serum concentration in moderate intensity (1721.51±315 to 1429.85±218 pg/mL) and high intensity groups (1684.26±289 to 1344.12±302 pg/mL) after exercise training (p<0.05). This decreases in both exercise training groups were significantly different with detrained (1711.82±272 to 1701.65±254 pg/mL) (p<0.05). In HOMA-IR values, a decrease was observed in moderate (3.01±0.8 to 2.61±0.8) and high intensity groups (2.87±0.9 to 1.84±0.6) after exercise training to compare with baseline (p<0.05). This decreases in both exercise groups were significantly different with detrained (2.95±0.7 to 3.11±0.9), too (p<0.05).In conclusion, the findings suggest that for decrease of Lcn2, in comparison with IL-1β and HOMA-IR, perhaps its need to weight loss and participation in exercise training intensity with more than 45-55% VO2max.
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