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the effect of 4 weeks exercise on mRNA of GDNF in rat’s hippocampus with AD induced by Aβ1-42 injection

Document Type : Research Paper

Authors

1 Ph.D. Student of Exercise Physiology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran

2 Professor of Exercise Physiology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.

3 Associate professor of Exercise Physiology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran

4 Ph.D. of Exercise Physiology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran

Abstract

Abstract: Alzheimer's disease (AD) is the most common form of dementia and amyloid
peptides playing a central role in its pathogenesis. Recently, regular exercise has been
considered as one of the most important non-pharmacological mechanisms to contrast with
AD. The aim of this study was to investigate the effect of 4 weeks exercise on mRNA of GDNF in rat’s hippocampus with AD induced by Aβ1-42 injection.
Methods: 56 male rats with mean±SD weight of 195±20 g were randomly divided
Into four groups: training group, Aβ-42 induction + training group, Aβ-42 induction group and control group. injection of Aβ1-42 into the hippocampus was performed. Seven days
after surgery, rats of each groups were either sacrificed or subjected to behavioral
testing, randomly. Real-Time PCR were used for investigation of mRNA GDNF.
Results: there is a significant difference between the groups. Gene expression level in training group was higher and in the Aβ-42 induction group was lower (p < 0.001). Moreover, spatial learning and memory were significantly better in the exercise + AD than AD group (p < 0.01).
Conclusion: It seems that 4 weeks of exercise could improve spatial memory and learning. Moreover, aerobic exercise could increase the level of neurotrophic factors gene expression specially GDNF in rat’s hippocampus.

Keywords

References
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Sport Physiology
Volume 13, Issue 49
March 2021
Pages 169-198
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History
  • Receive Date: 13 October 2019
  • Revise Date: 04 February 2020
  • Accept Date: 05 February 2020
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