Effects of two types of acute resistance exercise with high intensity and volume on α2bβ3 receptor, and platelet function and activation in healthy individuals

Document Type : Research Paper

Authors
Zahra Ebrahimi 1
Sajjad Ahmadizad 1
Alireza Farsinejad 2
Mohammad Hossein mohammadi 3
1 Department of Biological Sciences in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran
2 Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran
3 HSCT Research Center, Laboratory Hematology and Blood Banking Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran
10.22089/spj.2022.12281.2179
Abstract
The aim of this study was to investigate the effect of two types of resistance exercises of high volume (HV) and high intensity (HI) on α2bβ3 receptor, and markers of platelet activation and function. Among the volunteers, 10 individuals familiar with resistance training (6 women and 4 men; age, 28±5 years; weight, 67.1± 10.7 kg; height, 168±9 cm) performed two resistance exercises of HV and HI including 5 exercises. In HV protocol subjects performed 4 sets of 10-12 repetitions at 70% of 1RM with 1 min rest between sets and exercises and in HI protocol subjects performed 4 sets of 3-5 repetitions at 90% of 1RM with 3 min rest between sets and exercises. Blood samples were taken before, immediately after exercise and after 30 min recovery for measuring PDW, PLT, MPV, PAC1, CD41a, CD42b and CD62p. Data were analyzed using two-way repeated measures of ANOVA. Significant increases in blood lactate levels, PLT following resistance exercise were higher in response to HI protocol were higher than HV protocol. The results showed a significant decrease in CD41a (α2bβ3 receptor) and CD42b, and a significant increase in PAC1 and CD62p (p<0.05). Changes in CD41a, CD62p, and PAC1 were higher following HI than the HV protocol (p<0.05). Based on the findings of present study it could be concluded that α2bβ3 receptor, markers of platelet activation and function change in response to resistance exercise and that intensity of resistance exercise is more effective than volume of exercise.
Keywords
P-selectin
Exercise intensity
Exercise volume
Platelet activation
Resistance exercise
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Sport Physiology
Volume 14, Issue 55
December 2022
Pages 151-170

  • Receive Date 14 February 2022
  • Revise Date 26 March 2022
  • Accept Date 19 April 2022