Document Type : Research Paper
Authors
1 Master's student, Department of Sports Sciences, Faculty of Educational Sciences and Psychology, University of Sistan and Baluchistan, Zahedan, Iran.
2 Department of Sport scoences, Faculty of educational sciences and psychology, University of Sistan and Baluchestan, Zahedan. Iran.
3 Department of Sport Sciences, Faculty of Literature and Humanities, University of Zabol, Zabol, Sistan & Baluchestan, Iran
4 Department of internal medicine, Zahedan University of medical science, Zahedan, Iran.
Abstract
Objectives: Hypothyroidism is one of the thyroid disorders that increases the levels of fatty acid binding protein 4 (FABP4) and high-sensitivity C-reactive protein (hs-CRP) in the vascular endothelium. This study was conducted with the aim of investigating the effect of eight weeks of high-intensity interval training and Nasturtium officinale consumption on the serum levels of hs-CRP and FABP4 in overweight subclinical hypothyroid patients.
Materials and Methods: This study is a single-blind randomized clinical trial that 40 people with overweight subclinical hypothyroidism with average age (30.50±6.41 year) and average weight (73.20±6.48 kg) were randomly divided into four groups: training, training + supplement, supplement and control. For 8 weeks, training and training + supplement groups followed the program of three sessions per week of high-intensity interval training and training + supplement and supplement groups followed the daily consumption of 500 mg of Nasturtium officinale extract supplement. Study variables were measured at the beginning and end of the study. The data were analyzed using paired t-tests, analysis of covariance and Tukey's post hoc analysis and using SPSS version 20 software at a significant level (P<0.05).
Results: Eight weeks of high-intensity interval training and Nasturtium officinale supplement caused a significant decrease in hs-CRP and body mass index in training, training +supplement and supplement groups (P<0.05). While FABP4 was significantly decreased only in training groups (P<0.05).
Conclusion: It seems that intense interval training and Nasturtium officinale regulate energy metabolism and improve inflammation in overweight people with mild hypothyroidism.
Keywords
- Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic cardiac failure. Part 2: Causal mechanism and treatment. Circulation. 2002; 105:1503–8.
- Tohidi M, Rostami M, Asgari S, Azizi F. The association between sub-clinical hypothyroidism and metabolic syndrome: a population-based study. Iranian J Endocrinol Metab. 2011;13(1):98-105.
- Cojić M, Cvejanov-Kezunović L. Subclinical hypothyroidism-whether and when to start treatment? Open Access Maced J Med Sci. 2017; 5:1042–6.
- Vanderpump M. The epidemiology of thyroid disease. Br Med Bull 2011; 99:39–51.
- Raza SA, Mahmood N. Subclinical hypothyroidism: controversies to consensus. Indian J Endocrinol Metabc. 2013; 17:636–42.
- Suh S, Kim DK. Subclinical hypothyroidism and cardiovascular disease. Endocrinol Metab (Seoul). 2015;30(3):246-51.
- Xu W, Tian M, Zhou Y. The relationship between insulin resistance, adiponectin and C-reactive protein and vascular endothelial injury in diabetic patients with coronary heart disease. Exp Ther Med. 2018;16(3):2022-6.
- Al-Tu’maaFJ, Abd-YaseraZA, Al-NaffiKO. Association between hs-CRP levels and the severity of coronary atherosclerosis. J Contemp Med Sci. 2016;2(6):42-44.
- Jensen P, Skov L. Psoriasis and Obesity. Dermatology. 2016;232(6):633-9.
- Tan M, Korkmaz H, Aydın H, Kumbul Doğuç D. FABP4 levels in hypothyroidism and its relationship with subclinical atherosclerosis. Turk J Med Sci. 2019;49(5):1490-7.
- Rhee E, Lee W, Park C, Oh K, Kim B, Sung K, et al. The association of serum adipocyte fatty acid-binding protein with coronary artery disease in Korean adults. Eur J Endocrinol. 2009;160(2):165-72.
- Gökhan S. Inflammation and metabolic disorders. Nature. 2006;444(7121):860-7.
- Laursen P B, Jenkins D G. The scientific basis for high-intensity interval training. Sports Med. 2002;32(1):53-73.
- Little JP, Safdar A, Wilkin GP, Tarnopolsky MA & Gibala MJ. A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: Potential mechanisms. J Physiol. 2010;588(6):1011-22.
- Bahram ME, Pourvaghar MJ. The effect of 12 weeks of high intensity interval training (HIIT) on homocysteine and CRP cardiovascular risk factors and body composition in overweight men. Journal of Advanced Biomedical 2016; 6:334-342. (In Persian).
- Atashak S, Ahmadi-Zad A. Effect of eight weeks of resistance exercise on new biomarkers of cardiovascular disease in obese adult males. 2017;21(3):256-64. (In Persian).
- Yehuda H, Soroka Y, Zlotkin-Frušić M, Gilhar A, Milner Y, Tamir S. Isothiocyanates inhibit psoriasis-related pro inflammatory factors in human skin. Inflamm Res. 2012;61(7):735-42.
- Sakil M, Polash S, Hossain m. Evaluation of morphological traits, phytochemical compositions and antioxidant properties of watercress leaves. Prog Agri-culture. 2019; 30:10-6.
- Taghian F, Zolfaghari M, Hedayati M. Effects of aerobic exercise on serum retinol bindingprotein4, insulin resistance and blood lipids in obese women. Iran J Public Health. 2014;43(5):658-65.
- Ozen t. Investigation of antioxidant properties of nasturtium officinale (watercress) leaf extracts. Acta Pol Pharm. 2009;66(2):187-93.
- Gill CI, Haldar S, Boyd LA, Bennett R, Whiteford J, Butler M, et al. Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults. Am J Clin Nutr. 2007;85(2):504-10.
- Sumida S, Doi T, Sakurai M, Yoshioka Y, Okamura K. Effect of a single bout of exercise and β-carotene supplementation on the urinary excretion of 8-hydroxy-deoxyguanosine in humans. Free Radical Research.1997;27(6):607-18.
- Sedaghattalab M, Razazan M, Shahpari M, Azarmehr N, Abbasi Larki R, Sadeghi H, et al. The effect of the hydro alcoholic extract of watercress on the levels of protein carbonyl, inflammatory markers, and vitamin E in chronic hemodialysis patients. Biochem Res Int. 2021:5588464.
- Arboleda-Serna VH, Feito Y, Patiño-Villada FA, Vargas-Romero AV, Arango-Vélez EF. Effects of high-intensity interval training compared to moderate-intensity continuous training on maximal oxygen consumption and blood pressure in healthy men: a randomized controlled trial. Biomedica. 2019;39(3):524-36.
- Vakili J, Amirsasan R, Nourmohammadi O. The effect of four weeks HIIT with ginseng supplementation on aerobic and anaerobic powers and body composition of overweight and obese females. Journal of Sport and Exercise Physiology. 2019;29(12):45-54. (In Persian).
- Sedaghattalab M, Razazan M, Sadeghi H, Doustimotlagh AH, Toori MA, Abbasi Larki R, et al. Effects of Nasturtium officinale extract on antioxidant and biochemical parameters in hemodialysis patients: a randomized double-blind clinical trial. Evid Based Complement Alternat. 2021;1632957.
- Xu A, Tso AW, Cheung BM, Wang Y, Wat NM, Fong CH, et al. Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation. 2007;115(12):1537-43.
- Safarzade A. Effect of progressive resistance training on serum A-FABP and Apolipoprotein A-I concentration in male rats. Sport Physiology. 2014;6(21)22-109. (In Persian).
- Choi KM, Kim TN, Yoo HJ, Lee KW, Cho GJ, Hwang TG, et al. Effect of exercise training on AFABP, lipocalin- 2 and RBP4 levels in obese Clin Endocrinol (Oxf) 2009;70(4):569-74.
- Sari-Sarraf V, Amirsasan R, Khajehdizaj N. Effects of HIIT and MICT combined with ICR on FM and LBM in overweight women. Applied Health Studies in Sport Physiol. 2020;7(2):20-8.
- Trojnar M, Patro-Małysza J, Kimber-Trojnar Z, Leszczy B, Gorzelak N, Mosiewicz J. Associations between fatty acid-binding protein 4– a pro inflammatory adipokine and insulin resistance gestational and type 2 diabetes mellitus. Cells 2019;8(3):227.
- Vakili J, Sari-Sarraf V,Khanvari T. The effect of 8 weeks of HIIT on inflammatory factors in overweight adolescent boys. Journal of Sport Biosciences. 2020;13(1):59-73. (In Persian).
- Salimi Avansar M, Abdolsaleh Z. Comparing the effect of endurance and high intensity interval trainings on levels of chemerin and protein of C-reactive Plasma in Obese children. Journal of Arak University of Medical Sciences. 2017; 20(119):54-66. (In Persian).
- Gaini A, Nazari A, Tabrizi A, Farahani A. The effect of an eight-week aerobic training on high sensitivity C-reactive protein of high school students with different body mass indexes. Cardiovascular Nursing Journal 2013;1(4):48-56.
- Bahmanbeglou NA, Ebrahim K, Maleki M, Nikpajouh A, Ahmadizad S. Short-duration high-intensity interval exercise training is more effective than long duration for blood pressure and arterial stiffness but not for inflammatory markers and lipid profiles in patients with stage 1 hypertension. J Cardiopulm Rehabil Prev 2019;39(1):50-55.
- Dâmaso AR, da Silveira Campos RM, Caranti DA, de Piano A, Fisberg M, Foschini D, et al. Aerobic plus resistance training was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than aerobic training in obese adolescents. J Sports Sci. 2014;32(15):1435-45.
- Lean MEJ, Noroozi M, Kelly I, Burns J, Talwar D, Sattar N, Crozier A. Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes.1999;48(1):176-81.
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