The effect of high intensity interval training on neutropenia in patients with lymphoma and multiple myeloma after hematopoietic stem cell transplantation

Document Type : Research Paper

Authors
Tayebe Zarekar 1
Sajad Ahmadizad 1
Abbas Hajifathali 2
1 Department of Biological Sciences in Sports, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran
2 Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
10.22089/spj.2023.14364.2234
Abstract
Objectives: Chemotherapy induced immune-suppression is a side effect of cancer treatment. Exercise is an effective regulator for the survival and function of immune cells. Therefore, the aim of this study was to investigate the effect of high intensity interval training (HIIT) on neutropenia in cancer patients after hematopoietic stem cell transplantation.
Materials and Methods: 20 patients with lymphoma and multiple myeloma were divided into exercise and control groups. Exercise group performed a graded exercise test and then for five days, performed exercise training on ergo cycle for 24 minutes (three periods of four min work and rest with 80 and 40 % of peak power), while the control group did not have any exercise activities. Blood sampling was done daily during the treatment period. Statistical analysis of the data was done with SPSS software and ANOVA, independent t and Mann-Whitney U tests at a significance level of less than 0.05.
Results: The number of white blood cells on the day of cell collection and leukocyte transplantation was significantly higher in the exercise group than in the control group (P<0.05). The amount and number of days of administration of granulocyte colony stimulating factor before transplantation in the exercise group were significantly lower than the control group (P<0.05). The number of days of neutropenia and the amount of antibiotics used did not show any significant difference between the two groups (P>0.05).
Conclusion: Considering the positive effect of training on leukocyte engraftment, probably patients can benefit from training in addition to routine care.
Keywords
leukocyte engraftment
white blood cell
cancer
antibiotic
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Sport Physiology
Volume 15, Issue 58
July 2023
Pages 101-124

  • Receive Date 12 February 2023
  • Revise Date 05 October 2023
  • Accept Date 02 December 2023