Objective:: This study investigated the effect of different exercise intensities in hypoxia and normoxia on liver fat content and endurance performance of rats. Methods & Materials: 48 male Wistar rats (5 weeks) were randomly divided into groups of normal diet (ND), high-fat diet (HFD), high-fat diet and moderate-intensity training (HFD-MICT), high-fat diet and hypoxia moderate-intensity training. (HFD-HMICT), high-fat diet and high-intensity interval training (HFD-HIIT), high-fat diet and hypoxia high-intensity interval training (HFD-HHIIT). After determining the maximum aerobic velocity, the exercises were performed for 12 weeks and three sessions per week in normoxia (altitude ̴of 50 m) and hypoxia-hypobaric (altitude ̴ 3000 m). Results: The results showed that weight, liver fat content, and leukocyte number were higher in the HFD group, and endurance performance was lower than in all groups (p<0.05). The lowest rate of weight gain and fat content and the highest endurance performance were in the high-intensity interval training groups (p<0.05). There was no significant difference between HFD-HHIIT and HFD-HIIT groups. Endurance performance in MICT groups was lower than in HIIT groups. The increase in aerobic performance under hypoxic conditions was independent of RBC and HGB changes. Conclusions: MICT in hypoxia did not bring additional benefits in reducing liver fat content compared to normoxia. The increase in endurance performance in the HFD-HHIIT group is independent of changes in blood factors related to oxygen transport capacity; probably, the intervention of this research does not induce sufficient stimulation for blood changes due to short-term exposure to hypoxia.
Kim Y, Han E, Lee JS, Lee HW, Kim BK, Kim MK, et al. Cardiovascular Risk Is Elevated in Lean Subjects with Nonalcoholic Fatty Liver Disease. Gut Liver. 2022;16(2):290-9.
Hosseini, S. M. and Mohebbi, H. (2024). The effect of different exercise intensities in hypoxia and normoxia conditions on liver fat content, blood cells, and endurance performance of male rats under high-fat diet. Sport Physiology, 16(61), 65-86. doi: 10.22089/spj.2024.16535.2303
MLA
Hosseini, S. M. , and Mohebbi, H. . "The effect of different exercise intensities in hypoxia and normoxia conditions on liver fat content, blood cells, and endurance performance of male rats under high-fat diet", Sport Physiology, 16, 61, 2024, 65-86. doi: 10.22089/spj.2024.16535.2303
HARVARD
Hosseini, S. M., Mohebbi, H. (2024). 'The effect of different exercise intensities in hypoxia and normoxia conditions on liver fat content, blood cells, and endurance performance of male rats under high-fat diet', Sport Physiology, 16(61), pp. 65-86. doi: 10.22089/spj.2024.16535.2303
CHICAGO
S. M. Hosseini and H. Mohebbi, "The effect of different exercise intensities in hypoxia and normoxia conditions on liver fat content, blood cells, and endurance performance of male rats under high-fat diet," Sport Physiology, 16 61 (2024): 65-86, doi: 10.22089/spj.2024.16535.2303
VANCOUVER
Hosseini, S. M., Mohebbi, H. The effect of different exercise intensities in hypoxia and normoxia conditions on liver fat content, blood cells, and endurance performance of male rats under high-fat diet. Sport Physiology, 2024; 16(61): 65-86. doi: 10.22089/spj.2024.16535.2303