Document Type : Research Paper
Author
Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran
Abstract
Objective: The aim of the present study was to investigate the effect of eight weeks of endurance exercise on the expression of the Stem cells antigen-1 (Sca-1) gene in cardiac hypertrophy of male Wistar rats. Methods and materials: In this experimental study, 16 adult male Wistar rats were divided into two groups of eight: control and endurance training. The endurance training group performed continuous treadmill running for 50 minutes, five days a week, at an intensity of 65-70% Vo2 max for a period of eight weeks. The control group did not engage in any exercise during this time. After 48 hours following the last training session, the rats were dissected. The heart-to-body weight ratio and left ventricular wall thickness were measured to assess cardiac hypertrophy in the Wistar rats. The expression level of the Sca-1 gene in the heart was also measured using Real-time PCR. In the end, the collected data were evaluated using independent t-test at a significance level of 0.05. Results The results showed that both heart-to-body weight ratio and left ventricular wall thickness were significantly higher in the endurance exercise group compared to the control group. Additionally, Sca-1 levels were significantly increased in the endurance exercise group compared to the control group. Conclusions: It appears that endurance exercise can have prominent effects on cardiac hypertrophy by regulating an increase in Sca-1 expression
Keywords
Main Subjects
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