Influence of Exercise Training on expression of Some Cerebral proteins involved in APP Processing in Rat Models of Alzheimer's Disease: A Meta-Analysis

Document Type : Research Paper

Authors

1 Department of Sport Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran

2 Assistant Professor in Exercise Physiology, Azarbaijan Shahid Madani University, Tabriz, Iran

3 Azarbaijan shahid madani university

Abstract

This study aimed to estimate effects from exercise training interventions on expression level of cerebral ADAM10 (primary outcome) along with BACE1, sAPPα, sAPPβ, Aβ and spatial memory function (secondary outcomes) in rat models of Alzheimer's Disease (AD).
Interventions with at least, 3 weeks of exercise training published up to July 2024 were searched. SMDs of the 14 interventions measuring expression of cerebral ADAM10, BACE1, sAPPα, sAPPβ, Aβ and spatial memory function were determined. The correlation between SMD of exercise training interventions on cerebral ADAM10 and BACE1 expressions was assessed using Pearson coefficient. Regressions of participants’ age and also intervention duration with both of the aforementioned SMDs were quantified using action of moment meta-regression model.
The overall pooled net effect for all included exercise training interventions on cerebral ADAM10 expression(n=14) following publication bias analysis (SMD=0.73, CI95%: -0.43 to 1.91), was not statistically significant (according to CI values). However; in analysis the secondary outcomes, significant effect sizes were estimated for cerebral sAPPβ (SMD= -2.59, CI95%: -3.80 to -1.39) as well as Aβ (SMD= -4.03, -2.92 to -5.13) expression levels. In brain region category subgroup analysis, significant effect sizes were observed only for hippocampal expression levels of ADAM10 (SMD= 2.48, p=0.001) and BACE1 (SMD= -2.03, p=0.001).
Although Elevated and suppressed hippocampal ADAM10 and BACE1 expressions, with concomitant decreases in sAPPβ and Aβ expressions in whole brain samples, is promising for cerebral amyloid load reductions, especially in early stages of the AD, however; these finding still remains to be verified in human subjects.

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History

  • Receive Date: 01 September 2024
  • Revise Date: 07 December 2024
  • Accept Date: 30 December 2024

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