Document Type : Research Paper
Authors
Ferdowsi University of Mashhad, Faculty of Physical Education and Sport Sciences
Abstract
The aim of this study was to investigate the effect of resistance training with different intensities on serum irisin levels in sedentary young women. In this semi experimental study, 21 sedentary young women with range of 20-30 years and BMI 22-25 kg/m2 were selected by convenience sampling. Then, the volunteers were randomly assigned into two groups, [resistance training group with low intensity (40-60% of one repetition maximum) and high intensity (70-90% of one repetition maximum)]. The selected training included: 8 weeks, 3 times a week. Blood samples were obtained at baseline and 48 hours after at the end of the study. Data analysis was performed using SPSS software (version 15.0, SPSS). To make intra and between groups’ comparison, paired and independent student T test were used. For all statistical comparisons, the level of significance was considered at P0.05). Moreover, no significant changes were shown in body mass index and body fat percent in high-intensity training (P>0.05). While, the levels of irisin in high-intensity training reduced significantly (p=0.034). Variance between groups in variables irisin, BMI and body fat percent were not significant (P>0.05). These results suggest that the resistance training with low and high intensity ban not increase the levels of irisin in sedentary young women with BMI 22-25 kg/m2.
Keywords
1) Hosoda H, Kojima M, Kangawa K. Ghrelin and the regulation of food intake and energy balance. Molecular Interventions. 2002; 2(8): 494.
2) Woods S C, Benoit S C, Clegg D J, Seeley R J. Regulation of energy homeostasis by peripheral signals. Best Practice & Research Clinical Endocrinology & Metabolism. 2004; 18(4): 497-515.
3) Zhang J V, Ren P G, Avsian-Kretchmer O, Luo C W, Rauch R, Klein C, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science. 2005; 310(9): 5750-996.
4) Green B, Irwin N, Flatt P. Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice. Peptides. 2007; 28(5): 981-7.
5) Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, et al. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology. 2007; 148(1): 21-6.
6) Hillebrand J, De Wied D, Adan R. Neuropeptides, food intake and body weight regulation: A hypothalamic focus. Peptides. 2002; 23(12): 2283-306.
7) Gibala M J, Little J P, Van Essen M, Wilkin G P, Burgomaster K A, Safdar A, et al. Short-term sprint interval versus traditional endurance training: Similar initial adaptations in human skeletal muscle and exercise performance. The Journal of Physiology. 2006; 575(3): 901-11.
8) Wenz T, Rossi S G, Rotundo R L, Spiegelman B M, Moraes C T. Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proceedings of the National Academy of Sciences. 2009; 106(48): 20405-10.
9) Seale P, Conroe H M, Estall J, Kajimura S, Frontini A, Ishibashi J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. The Journal of Clinical Investigation. 2011; 121(1): 96-105.
10) Enerbäck S. Human brown adipose tissue. Cell Metabolism. 2010; 11(4): 248-52.
11) Boström P, Wu J, Jedrychowski M P, Korde A, Ye L, Lo J C, et al. A PGC1-[agr]-dependent myokine that drives brown-fat-likedevelopment of white fat and thermogenesis. Nature.2012; 481(7382): 463-8.
12) Xu X, Ying Z, Cai M, Xu Z, Li Y, Jiang S Y, et al. Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2011; 300(5): 1115-25.
13) Kelly D P. Irisin, light my fire. Science. 2012; 336(6077): 42-3.
14) Moreno-Navarrete J M, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism. 2013; 98(4): 769-78.
15) Blair S N, LaMonte M J, Nichaman M Z. The evolution of physical activity recommendations: How much is enough? The American Journal of Clinical Nutrition. 2004; 79(5): 913-20.
16) Kelley G A, Kelley K S. Impact of progressive resistance training on lipids and lipoproteins in adults: A meta-analysis of randomized controlled trials. Preventive Medicine. 2009; 48(1): 9-19.
17) Ormsbee M J, Thyfault J P, Johnson E A, Kraus R M, Choi M D, Hickner R C. Fat metabolism and acute resistance exercise in trained men. Journal of Applied Physiology. 2007; 102(5): 1767-72.
18) Pitsavos C, Panagiotakos D, Tambalis K, Chrysohoou C, Sidossis L, Skoumas J, et al. Resistance exercise plus to aerobic activities is associated with better lipids’ profile among healthy individuals: The ATTICA study. QJM. 2009; 102(9): 609-16.
19) محمدپور هدیه، فرامرزی محمد، نادر رهنما. تأثیر مصرف اسید چرب امگا-3 به همراه تمرینات مقاومتی بر برخی فاکتورهای آمادگی جسمانی در زنان سالمند سالم. نشریۀ فیزیولوژی ورزشی. 1393؛ 6(22): 54ـ41.
20) Volek J S, Kraemer W J, Bush J A, Boetes M, Incledon T, Clark K L, et al. Creatine supplementation enhances muscular performance during high-intensity resistance exercise. Journal of the American Dietetic Association. 1997; 97(7): 765-70.
21) Schuster D P, Editor Changes in physiology with increasing fat mass. Seminars in pediatric surgery; Elsevier. 2009; 18(3): 126-35.
22) Poehlman E, Melby C. Resistance training and energy balance. International Journal of Sport Nutrition. 1998; 8: 143-59.
23) Choi Y K, Kim M K, Bae K H, Seo H, Jeong J Y, Lee W K, et al. Serum irisin levels in new-onset type 2 diabetes. Diabetes Research and Clinical Practice. 2013; 100(1): 96-101.
24) Liu J J, Wong M D, Toy W C, Tan C S, Liu S, Ng X W, et al. Lower circulating irisin is associated with type 2 diabetes mellitus. Journal of Diabetes and its Complications. 2013; 27(4): 365-9.
25) Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, et al. Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: In vivo and in vitro studies. The Journal of Physiology. 2014; 592(5): 1091-107.
26) Timmons J A, Baar K, Davidsen P K, Atherton P J. Is irisin a human exercise gene? Nature. 2012; 488(7413): 9-10.
27) Pekkala S, Wiklund P K, Hulmi J J, Ahtiainen J P, Horttanainen M, Pöllänen E, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? The Journal of Physiology. 2013; 591(21): 5393-400.
28) رئیسی جلیل، رجبی حمید، قائدی کامران، مرندی سیدمحمد، دهخدا محمدرضا. تأثیر حاد تمرین مقاومتی بر میزان پروتئین آیریزین پلاسما و بیان ژنهای FNDC5 عضلانی و UCP1 بافت چربی موشهای صحرایی نر. دانشکدۀ پزشکی اصفهان. 1392؛ 31(256): 66ـ1657.
29) خدادادی هاشم، رجبی حمید، عطارزاده حسینی سیدرضا، عباسیان صادق. اثر فعالیت ورزشی تناوبی شدید و پیلاتس بر سطح آیریزین سرمی و مقاومت به انسولین زنان دارای اضافه وزن. غدد و متابولیسم ایران. دانشگاه علوم پزشکی و خدمات بهداشتی ـ درمانی شهید بهشتی. 1393؛ 16(3): 6ـ190.
30) گائینی عباسعلی، رجبی حمید. آمادگی جسمانی. چاپ ششم. تهران: سازمان مطالعه و تدوین کتب علوم انسانی دانشگاهها (سمت)، مرکز پژوهش و توسعۀ علوم انسانی؛ 1382. ص 81ـ159.
31) ریچاردو لاتین، ال کی ثیگپن، استفن جی رایس، دانیل بلنک. نکات اساسی در بدنسازی (پرسش و پاسخ). مترجمان: واعظموسوی سیدمحمدکاظم ، آفرینش خاکی اکبر. چاپ اول. تهران: انتشارات کمیتۀ ملی المپیک جمهوری اسلامی ایران؛ 1374
32) علیجانی عیدی. علم تمرین. چاپ دوم. تهران: انتشارات پژوهشکدۀ تربیتبدنی و علوم ورزشی. چکامه؛ 1387.
33) عابدی بهرام، عابدی بهزاد. اثر تمرین مقاومتی بر برخی عوامل آمادگی جسمانی و نشانگرهای التهابی در مردان دارای اضافهوزن. علوم زیستی ورزشی. 1392؛ 5(4): 64ـ49.
34) احمدیکانی گلزار فرهاد، شیخالاسلامی وطنی داریوش، کشکولی وحید، مرادی هادی، فرهنگیان محمد. تأثیر مکمل پروتئین whey ایزولات و تمرین قدرتی بر کاهش وزن، ترکیب بدنی، قدرت و هیپرتروفی عضلانی در مردان جوان دارای اضافهوزن. نشریۀ علوم تغذیه و صنایع غذایی ایران. 1391؛ 7(2): 46ـ37.
35) Dionne I J, Mélançon M O, Brochu M, Ades P A, Poelhman E T. Age-related differences in metabolic adaptations following resistance training in women .Experimental Gerontology. 2004; 39(1): 133-8.
36) Poehlman E T, Denino W F, Beckett T, Kinaman K A, Dionne I J, Dvorak R, et al. Effects of endurance and resistance training on total daily energy expenditure in young women: A controlled randomized trial. The Journal of Clinical Endocrinology & Metabolism. 2002; 87(3): 1004-9.
37) خلیلی ثریا، نوری رضا. اثر 8 هفته تمرین مقاومتی بر لپتین و شاخص مقاومت به انسولین در دختران چاق. دانشگاه علوم پزشکی و خدمات بهداشتی درمانی همدان. 1391؛ 20(1): 65ـ59.
38) ثاقبجو مرضیه، دستیگردی سمیه، افضلپور محمداسماعیل، هدایتی مهدی. اثر تمرین هوازی و مقاومتی بر سطوح ویستافین پلاسمای زنان دارای اضافهوزن. نشریۀکومش. 1390؛ 2(42): 33ـ225.
39) جعفری احمد، رمضانی علیرضا. اثر 8 هفته تمرین همزمان استقامتی تناوبی و مقاومتی و استقامتی تداومی و مقاومتی بر قدرت، ترکیب بدنی و پروفایلهای لیپید در پسران غیرورزشکار 14 تا 17 سال دارای اضافهوزن. علوم زیستی ورزشی. 1391؛ (15): 22ـ5.
40) Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp B F. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index. Peptides. 2013; 39: 125-30.
41) Aydin S, Aydin S, Kuloglu T, Yilmaz M, Kalayci M, Sahin İ, et al. Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45min of a Turkish bath or running. Peptides. 2013; 50: 8-13.
42) Scharhag-Rosenberger F, Morsch A, Wegmann M, Ruppenthal S, Kaestner L, Meyer T, et al. Irisin does not mediate resistance training-induced alterations in RMR. Medicine and Science in Sports and Exercise; 2014 .Retrieved from: http://www.pubfacts.com.
43) Moraes C, Leal V, Marinho S, Barroso S, Rocha G, Boaventura G, et al. Resistance exercise training does not affect plasma irisin levels of hemodialysis patients. Hormone and Metabolic Research. 2013; 63(12): 900-4.
44) Hofmann T, Elbelt U, Ahnis A, Kobelt P, Rose M, Stengel A. Irisin levels are not affected by physical activity in patients with anorexia nervosa. Frontiers in Endocrinology 2014. Rerieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3880939/.
45) Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, et al. Evidence against a beneficial effect of irisin in humans. PloS One. 2013; 8(9): 73680.
46) Huh J Y, Panagiotou G, Mougios V, Brinkoetter M, Vamvini M T, Schneider B E, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism. 2012; 61(12): 1725-38.
47) Hecksteden A, Wegmann M, Steffen A, Kraushaar J, Morsch A, Ruppenthal S, et al. Irisin and exercise training in humans-Results from a randomized controlled training trial. BMC Medicine. 2013; 11(1): 235.
48) Handschin C, Spiegelman B M. The role of exercise and PGC1α in inflammation and chronic disease. Nature. 2008; 454(7203): 463-9.
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