Introduction and Objective: This study aimed to investigate the response of some anabolic indicators (insulin-like growth factor-1 and growth hormone) to four weeks of resistance training with and without blood flow restriction in young professional male volleyball players.

Research Method: The statistical population in the present quasi-experimental study was young male professional volleyball players in Zahedan city with the age range of 20-25 years. 20 volleyball players were purposefully selected as a sample and randomly assigned to two BFR and NBFR groups. The BFR group underwent a blood flow restriction training program and the NBFR group did not have blood flow restriction during training. The NBFR group underwent a training program with an intensity of 70% and the BFR group underwent an intensity of 30% of one repetition maximum. Blood sampling was performed twice before and after the test under similar conditions. GH and IGH were measured using an ELISA kit made in Canada; independent t-test and paired t-test were used to test the hypotheses at a significance level of p<0.05 with SPSS-25 statistical software.

Results: The results showed that the levels of insulin-like growth factor-1 and growth hormone increased significantly in both groups (p=0.00). The results also showed that there was a significant difference between the two groups in the levels of insulin-like growth factor-1 (p=0.00). However, the levels of growth hormone did not show a significant difference (p=0.07).

Conclusion: It seems that the use of resistance training combined with blood flow restriction could be a suitable alternative