Document Type : Research Paper
Authors
- Babak Farzad
- Hamid Rajabi
- Reza Gharakhanlu
- Farinaz Nasiri Nejad
- Atoosa Janzadeh
- Sima Damani
- Behnamodin Jamei
Abstract
The present study examined the effects of swimming training on chronic constriction injury (CCI) of sciatic nerve in Wistar male rats. Forty Wistar eight-week rats were assigned into 5 groups: 1) CCI neuropathic pain with swimming training (CCIST); 2) CCI neuropathic pain without swimming training (CCI); 3) No CCI neuropathic pain with swimming training (ST); No CCI neuropathic pain without swimming training (Control); 5) CCI sham surgery (Sham CCI). CCI and CCIST groups underwent peripheral nerve injury by four loose ligatures around sciatic nerve. Swimming training program includes two weeks (5 sessions per week, 30-60 min per session). Behavioral tests included the study of mechanical and thermal hyperalgesia and allodynia, which was conducted every week. Statistical results showed that mechanical (P=0.023 and P=0.013, respectively) and thermal (P=0.013 and P<0.001, respectively) hyperalgesia was significantly different in the CCIST group comparing to CCI group at the first and second week; whereas mechanical and cold allodynia did not significantly change in the CCIST group comparing to CCI group. In conclusion, our findings showed that proper exercise training directly affects hyperalgesia and should be considered as an important rehabilitation therapy.
Keywords
Main Subjects
1. Toth C, Lander J, Wiebe S. The prevalence and impact of chronic pain with neuropathic pain symptoms in the general population. Pain Med. 2009; 10(5): 918-29.
2. Dworkin R H, Backonja M, Rowbotham M C, Allen R R, Argoff C R, Bennett G J, et al. Advances in neuropathic pain: Diagnosis, mechanisms, and treatment recommendations. Arch Neurol. 2003; 60(11): 1524-34.
3. Amin B, Hosseinzadeh H. Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia. 2012; 83(5): 888-95.
4. Niv D, Devor M. Refractory neuropathic pain: The nature and extent of the problem. Pain Pract. 2006; 6(1): 3-9.
5. Vogel T, Brechat P H, Leprêtre P M, Kaltenbach G, Berthel M, Lonsdorfer J. Health benefits of physical activity in older patients: A review. Int J ClinPract. 2009; 63(2): 303-20.
6. Koltyn K F. Analgesia following exercise: A review. Sports Med. 2000; 29(2): 85-98.
7. Koltyn K F, Arbogast R W. Perception of pain after resistance exercise. Br J Sports Med. 1998; 32(1): 20-4.
8. Hoffman M D, Shepanski M A, Mackenzie S P, Clifford P S. Experimentally induced pain perception is acutely reduced by aerobic exercise in people with chronic lowback pain. J Rehabil Res Dev. 2005; 42(2): 183-90.
9. Chen Y W, Li Y T, Chen Y C, Li Z Y, Hung CH. Exercise training attenuates neuropathic pain and cytokine expression after chronic constriction injury of rat sciatic nerve. Anesth Analg. 2012; 114(6): 1330-7.
10. Kuphal K E, Fibuch E E, Taylor B K. Extended swimming exercise reduces inflammatory and peripheral neuropathic pain in rodents. J Pain. 2007; 8(12): 989-97.
11. Koltyn K F, Garvin A W, Gardiner R L, Nelson T F. Perception of pain following aerobic exercise. Med Sci Sports Exerc. 1996; 28(11): 1418-21.
12. Shen J, Fox L E, Cheng J. Swim therapy reduces mechanical allodynia and thermal hyperalgesia induced by chronic constriction nerve injury in rats. Pain Med. 2013; 14(4): 516-25.
13. Cobianchi S, Marinelli S, Florenzano F, Pavone F, Luvisetto S. Short- but not long-lasting treadmill running reduces allodynia and improves functional recovery after peripheral nerve injury. Neuroscience. 2010; 168(1): 273-87.
14. صارمی عباس، چنگیزی آشتیانی سعید، کلانتری ابوالفضل. ترکیب ویتامین E و تمرین شدید بر استرس اکسیداتیو بیضه و اسپرماتوژنز در موشهای نر. نشریۀ فیزیولوژی ورزشی. 1393؛ 6(23): 54ـ43.
15. Bennett G J, Xie Y K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988; 33(1): 87-107.
16. Sene-Fiorese M, Duarte F O, Scarmagnani F R, Cheik N C, Manzoni M S, Nonaka K O, et al. Efficiency of intermittent exercise on adiposity and fatty liver in rats fed with high-fat diet. Obesity (Silver Spring). 2008; 16(10): 2217-22.
17. Goes A T, Souza L C, Filho C B, Del Fabbro L, De Gomes M G, Boeira S P, et al. Neuroprotective effects of swimming training in a mouse model of Parkinson's disease induced by 6-hydroxydopamine. Neuroscience. 2014; 256: 61-71.
18. Masoumipoor M, Jameie S B, Janzadeh A, Nasirinezhad F, Soleimani M, Kerdary M. Effects of 660- and 980-nm low-level laser therapy on neuropathic pain relief following chronic constriction injury in rat sciatic nerve. Lasers Med Sci. 2014; 29(5): 1593-8.
19. Bonin R P, Bories C, De Koninck Y. A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments. Mol Pain. 2014; 10(1): 26.
20. Chaplan S R, Bach F W, Pogrel J W, Chung J M, Yaksh T L. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994; 53(1): 55-63.
21. Choi Y, Yoon Y W, Na H S, Kim SH, Chung J M. Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain. 1994; 59(3): 369-76.
22. Hutchinson K J, Gómez-Pinilla F, Crowe M J, Ying Z, Basso D M. Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats. Brain. 2004; 127(Pt 6): 1403-14.
23. Martucci C, Trovato A E, Costa B, Borsani E, Franchi S, Magnaghi V, et al. The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice. Pain. 2008; 137(1): 81-95.
24. Tsuda M, Mizokoshi A, Shigemoto-Mogami Y, Koizumi S, Inoue K. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia. 2004; 45(1): 89-95.
25. Inoue K. The function of microglia through purinergic receptors: Neuropathic pain and cytokine release. Pharmacol Ther. 2006; 109(1-2): 210-26.
26. Campbell J N, Meyer R A. Mechanisms of neuropathic pain. Neuron. 2006; 52(1): 77-92.
27. Kalmar B, Greensmith L, Malcangio M, McMahon S B, Csermely P, Burnstock G. The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury. Exp Neurol. 2003; 184(2): 636-47.
28. Saleh A, Srinivasula S M, Balkir L, Robbins P D, Alnemri E S. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000; 2(8): 476-83.
29. Jergová S, Cízková D. Microglial activation in different models of peripheral nerve injury of the rat. J Mol Histol. 2007; 38(3): 245-51.
30. Jacobs B L, Fornal C A. Serotonin and motor activity. Curr Opin Neurobiol. 1997; 7(6): 820-5.
31. Gerin C, Teilhac J R, Smith K, Privat A. Motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord. Neurosci Lett. 2008; 436(2): 91-5.
32. Korb A, Bonetti L V, da Silva S A, Marcuzzo S, Ilha J, Bertagnolli M, et al. Effect of treadmill exercise on serotonin immunoreactivity in medullary raphe nuclei and spinal cord following sciatic nerve transection in rats. Neurochem Res. 2010; 35(3): 380-9.
33. Bement M K, Sluka K A. Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner. Arch Phys Med Rehabil. 2005; 86(9): 1736-40.
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