Sport Physiology

Sport Physiology

Effect of blood flow restriction deal during isometric exercise on growth hormone and testosterone active males

Document Type : Research Paper

Authors
Aref Basereh 1
khosro ebrahim 2
fariborz hovanloo 3
poone dehghan 4
keivan khoramipour 5
1 M.Sc. of Exercise Physiology, Shahid Beheshti University of Tehran
2 Professor of Sport Biosciences, Shahid Beheshti University of Tehran
3 Associate Professor of Health and Exercise Rehabilitation, Shahid Beheshti University of Tehran
4 Assistant Professor, Clinical Research Center of Taleghani Hospital of Tehran
5 Ph. D Student of Sports Biochemistry, University of Tehran
10.22089/spj.2017.924
Abstract
The purpose of this study was to investigate the effect of the blood flow restriction deal (Kaatsu) during isometric exercise on growth hormone and testosterone in active males. 10 active males (1 to 3 times training per week, age: 23.8±2.32 years, BMI: 24.26±1.80 kg/m2) were participated in this study voluntarily. Subject’s ankle blood pressures were determined by color Doppler ultrasound. Then, subjects performed the study protocol that consisted of six 10-second isometric contractions with 60 seconds rest between each contraction with varying levels of external compression (0% (without compression), 70%, 100%, and 130% of systolic pressure). Blood samples were taken before, immediately after and 15 minute after exercise. Statistical analysis of data did not show significant difference (time × trial) between varying levels of external compression in growth hormone (GH), testosterone (T) and blood lactate (BL). GH, T and BL increased significantly (time) from pre to postexercise in the all varying levels of external compression (p<0.05), and except of T (p=0.074), GH and BL was increased significantly pre to 15 minute after exercise in all varying levels of external compression. On the basis of results, by increasing pressure of blood flow restriction the levels of GH and T increased further but there was no significant difference in the levels of GH and T between varying levels of external compression with the same intensity.
Keywords
Isometric activity
Kaatsu
Electromyography activity
Muscle fatigue
Blood Flow Restriction
Lactate

Subjects

  1. Kraemer WJ, Marchitelli L, Gordon SE, Harman E, Dziados JE, Mello R. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol. 1990; 69(4): 1442-50.
  2. Asghar Tofighi A J D, Tartibian B, Fatholahi Shourab F, Sinaei M. Effects of aerobic, resistance, and concurrent training on secretion of growth hormone and Insulin-like growth factor-1 in elderly women. Journal of Isfahan Medical School. 2012; 30(184):   427-38. )In Persian).
  3. Majumdar S S. Effects of training on hormones testosterone, cortisol and testosterone/ cortisol ratio in male and female Indian Swimmers. Int J of Swimming Kinetics. 2012; 1(1): 13-32.
  4. Kraemer WJ, Häkkinen K, Newton RU, Nindl BC, Volek JS, McCormick M, et al. Effects of heavy-resistance training on hormonal response patterns in younger vs older men. J Appl Physiol. 1999; 87(3): 982-92.
  5. Schumann M, W S, Izquierdo M, Newton R U, Kraemer W J, Hakkinen K, et al. The order effect of combined endurance and strength loadings on force and hormone responses: Effects of prolonged training. Euro J Appl Physiol. 2014; 114(1): 867-80.
  6. Cook SB, Clark BC, Ploutz-Snyder LL. Effects of exercise load and blood-flow restriction on skeletal muscle function.Med sci sport exer. 2007; 39(10): 1708-13.
  7. American College of Sports Medicine Position Stand. Progression models in resistance training for healthy adults. Sci Sports Exercise. 2009; 41(3): 687-708.
  8. Kubota A, Sakuraba K, Koh S, Ogura Y, Tamura Y. Blood flow restriction by low compressive force prevents disuse muscular weakness. J Sci Med Sport. 2011; 14(2):      95-109.
  9. Kubota A, Sakuraba K, Sawaki K, Sumide T, Tamura Y. Prevention of disuse muscular weakness by restriction of blood flow. Med Sci Sports Exercise. 2008; 40(3): 529-40.
  10. Yasuda T, Fukumura K, Fukuda T, Iida H, Imuta H, Sato Y, Yamasoba T, Nakajima T. Effects of low-intensity. Elastic band resistance exercise combined with blood flow restriction on muscle activation. Scand J Med Sci Sports. 2014; 24(1): 55-61.
  11. Reeves GV, Kraemer RR, Hollander DB, Clavier J, Thomas C, Francois M, et al. Comparison of hormone responses following light resistance exercise with partial vascular occlusion and moderately difficult resistance exercise without occlusion. J Appl Physiol. 2006; 101(6): 1616-22.
  12. Takarada Y, Takazawa H, Ishii N. Applications of vascular occlusion diminish disuse atrophy of knee extensor muscles. Med Sci Sports Exercise. 2000b; 32(12): 2035-9.
  13. Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, Ishii N. Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans. J Appl Physiol. 2000c; 88(6): 2097-106.
  14. Manini TM, Clark BC. Blood flow restricted exercise and skeletal muscle health. Exerc Sport Sci Rev. 2009; 37(2): 78-85.
  15. Fujita S, Abe T, Drummond MJ, Cadenas JG, Dreyer HC, Sato Y, et al. Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. J Appl Physiol. 2007; 103(3): 903-10.
  16. Takano H, Morita T, Iida H, Asada KI, Kato M, Uno K, et al. Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol. 2005; 95(1): 65-73.
  17. Takarada Y, Nakamura Y, Aruga S, Onda T, Miyazaki S, Ishii N. Rapid increase in Plasma growth hormone after low intensity resistance exercise with vascular occlusion. J Appl Physiol. 2000a; 88(1): 61-5.
  18. Loenneke J P, Fahs C A, Rossow L M, Sherk V D, Thiebaud R S, Abe T, et al. Effects of cuff width on arterial occlusion: Implications for blood flow restricted exercise. Eur J Appl Physiol. 2012; 112(8): 2903-12.
  19. Abe T, Yasuda T, Midorikawa T, Sato Y, Kearns C F, Inoue K, et al. Skeletal muscle size and circulating IGF-1 are increased after two weeks of twice daily" KAATSU" resistance training. International Journal of KAATSU Training Research. 2005; 1(1):        6-12.
  20. Loenneke JP, Wilson JM, Pujol TJ, Bemben MG. Acute and chronic testosterone response to blood flow restricted exercise. Horm Metab Res. 2011; 43(10): 669-73.
  21. Madarame H K, Sasaki, Ishii N. Endocrine responses to upper- and lower-limb resistance exercises with blood flow restriction. Acta Physiol Hung. 2010; 97(2): 192-200.
  22. Suga T, Okita K, Takada S, Omokawa M, Kadoguchi T, Yokota T, et al. Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction. Eur J Appl Physiol. 2012; 112(11): 1315-20.
  23. Loenneke J P, Fahs C A, Rossow L M, Sherk V D, Thiebaud R S, Abe T, et al. Effects of cuff width on arterial occlusion: Implications for blood flow restricted exercise. Eur J Appl Physiol. 2012; 112(8): 2903-12.
  24. Yasuda T, Brechue WF, Fujita T, Sato Y, Abe T. Muscle activation during low-intensity muscle contractions with varying levels of external limb compression. J Sports Sci Med. 2008; 7(4): 467-74.
  25. Wernbom M, Paulsen G, Nilsen TS, Hisdal J, Raastad T. Contractile function and sarcolemmal permeability after acute low-load resistance exercise with blood flow restriction. Eur J Appl Physiol. 2012; 112(6): 2051-63.
  26. Patterson, Stephen D, et al. Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men. Eur J Appl Physiol. 2013;113 (3): 713–9.
  27. Pierce JR, Clark BC, Ploutz-Snyder LL, Kanaley JA. Growth hormone and muscle function responses to skeletal muscle ischemia. J Appl Physiol (1985). 2006; 101(6): 1588-95.
  28. Madarame H, Neya M, Ochi E, Nakazato K, Sato Y, Ishii N. Cross-transfer effects of resistance training with blood flow restriction. Med Sci Sports Exerc. 2008; 40(2):         258-63.
  29. Ratamess NA, Kraemer WJ, Volek JS, Maresh CM, VanHeest JL, Sharman MJ, et al. Androgen receptor content following heavy resistance exercise in men. J steroid biochem. 2005; 93(1): 35-42.
  30. Raastad T, Bjoro T, Hallen J. Hormonal responses to high- and moderate-intensity strength exercise. Eur J Appl Physiol. 2000; 82(1-2): 121-8.
  31. Godfrey R J, Madgwick Z, Whyte G P. The exercise-induced growth hormone response in athletes. Sports Med. 2003; 33(8): 599-613.
  32. Lu SS, Lau CP, Tung YF, Huang SW, Chen YH, Shih HC, et al. Lactate and effects of exercise on testosterone secretion: Evidence for the involvement of a cAMP-mediated mechanism. Med Sci Sport Exer. 1997; 29(8): 1048-54.
  33. Tremblay MS, Copeland JL, Van Helder W. Influence of exercise duration on post-exercise steroid hormone responses in trained males. Eur J Appl Physiol. 2005; 94(5): 505-13.
  34. Smilios IL, Pilianidis TH, Karamouzis MI, Tokmakidis SP. Hormonal responses after various resistance exercise protocols. Med Sci Sport Exer. 2003; 35(4): 644-54.
  35. Fahrner C L, Hackney A C. Effects of endurance exercise on free testosterone concentration and the binding affinity of sex hormone binding globulin (SHBG). Int j sports med. 1998; 19(1): 12-5.
Sport Physiology
Volume 9, Issue 33
Spring 2017
Pages 51-68

  • Receive Date 05 November 2015
  • Revise Date 12 February 2016
  • Accept Date 24 February 2016