Adipokine and inflammatory biomarkers, facilitate the degradation effects of obesity, such as insulin resistance that, are susceptible to induction of metabolic disease. The purpose of the present study was to investigate the effect of 8 weeks of resistance, endurance and concurrent training on serum CTRP-12, Furin, KLF-15 and insulin resistance in sedentary obese men. 40 inactive obese men (30-45 yrs, BMI≥30) were randomly divided into 4 groups, resistance training, endurance training, concurrent training, and control. The training groups trained for 8 weeks, three sessions a week. Serum levels of CTRP-12, Furin and KLF-15 were measured using ELISA kits. Data were analyzed by t-test and ANOVA at the significance level (p ≤ 0.05). The result of dependent t-test showed that KLF-15 values of endurance training groups (p = 0.006) and concurrent (p = 0.036) significantly increased. However, furin values in these two groups showed a significant decrease (p = 0.001 and p = 0.044, respectively). The values of CTRP-12 were only significant increase in the concurrent training group (p = 0.023). endurance (p = 0.009) and concurrent (p = 0.006) groups have significantly decreased in insulin resistance. In the intergroup analysis, aerobic training induces a significant cheange in KLF-15 (P = 0.039) and furin (p = 0.031) compared to control group. It seems that the use of endurance training, and in particular concurrent training, has a better effect on lipid profiles, as well as the upregulation of new anti-inflammatory adipokines such as KLF-15 and CTRP-12, and downregulatin of inflammatory adipokine furin