Document Type : Research Paper

Authors

• H Mohebbi
• F Rahmani nia
• M Hedayati Emami
• T Saeidi Ziabari

Abstract

There are many different mediators such as apelin that have effective role of regular aerobic exercise on metabolic disorders and type 2 diabetes mellitus. The aim of present study was to investigate the effect of 8 weeks aerobic exercise on plasma apelin level and insulin resistance index in women with type 2 diabetes mellitus. Eighteen diabetic women (aged 53.61± 6.90 yrs, weight 64.54± 9.89, height 153.44± 6.26) selected as subjects and were randomly assigned into two exercise (n=9) and control (n=9) groups. Exercise training was performed 3 days per week, 30–60 minutes per session with intensity corresponding to 60-70% HR_max for 8 weeks. The body weight was decreased in exercise group in comparison with the controls (p<0.01). VO₂max was increased and plasma apelin, insulin levels and HOMA-IR index were decreased in the exercise group compare to pre-exercise and control groups (p<0.01). It can be concluded that the changes in apelin level and HOMA-IR are due to the body weight decrease and anti-inflammatory nature of exercise

Keywords

• Type 2 diabetes mellitus
• Plasma Apelin
• Insulin Resistance
• Aerobic Exercise