فیزیولوژی ورزشی

فیزیولوژی ورزشی

تاثیر هشت هفته تمرین ترکیبی بر بیان miR-146a، miR-21 و TLR-2 خون در زنان مبتلا به مولتیپل اسکلروزیس عودکننده- فروکش کننده

نوع مقاله : مقاله پژوهشی

نویسندگان
اکبر اعظمیان جزی 1
محمد شاه وردی شهرکی 2
محمد ربیعی 3
1 دانشیار، گروه علوم ورزشی، گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه شهرکرد، شهرکرد، ایران
2 دانشجوی کارشناسی ارشد فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه شهرکرد، شهرکرد، ایران
3 استادیار، گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه شهرکرد، شهرکرد، ایران
10.22089/spj.2025.16955.2320
چکیده
هدف: miR-146a، miR-21 و TLR-2 در فرایندهای ضد التهابی، میلین‌سازی مجدد و تنظیم پاسخ­های خود­ایمنی نقش دارند که ممکن است تحت تأثیر تمرینات ورزشی قرار گیرند. بنابراین، این مطالعه با هدف بررسی تاثیر هشت هفته تمرین ترکیبی بر بیان miR-146a، miR-21 و TLR-2 در زنان مبتلا به بیماری مولتیپل اسکلروزیس عودکننده- فروکش کننده (RRMS) انجام شد.
مواد و روش ها: بیست و سه زن (سن: 3/5±1/33 سال، وزن: 9/8±1/64 کیلوگرم و BMI: 4/9±3/33 کیلوگرم بر متر مربع) مبتلا به RRMS به طور تصادفی در دو گروه تمرین و کنترل قرار گرفتند. آزمودنی‌های گروه تمرین به مدت هشت هفته در تمرین ترکیبی تحت نظارت، شامل سه جلسه تمرین هوازی و یک جلسه تمرین مقاومتی شرکت کردند. بیان miR-146a، miR-21 و TLR-2 در خون قبل و بعد از هشت هفته تمرین ترکیبی با استفاده از تکنیک RT-PCR اندازه­گیری شد. داده­ها با آزمون آنوآ دو طرفه با اندازه­گیری­های مکرر و در سطح معناداری کم­تر از 05/0 آنالیز شد.
یافته ها: تحلیل داده­‌ها نشان داد که بیان نسبی miR-146a در زنان مبتلا به RRMS پس از هشت هفته تمرین ترکیبی در گروه تمرین نسبت به گروه کنترل به طور معناداری کمتر کاهش یافت (001/0P=) و بر عکس، بیان نسبی miR-21 و TLR-2 در گروه تمرین نسبت به گروه کنترل به طور معناداری کمتر افزایش یافت (001/0P=).
نتیجه گیری: تمرین ترکیبی ممکن است با تاثیر مطلوب بر miR-146a، miR-21 و TLR-2 نقش موثری در پیش­برد فرایند­های ضد التهابی، میلین‌سازی مجدد و تنظیم پاسخ­های خود­ایمنی در بیماری RRMS داشته باشد و در نتیجه، این بیماری را بهبود بخشیده و احتمال عود آن را کاهش دهد. بنابراین، استفاده از تمرین ترکیبی این تحقیق برای زنان مبتلا به RRMS توصیه می­شود.
کلیدواژه‌ها
مولتیپل اسکلروزیس
تمرین ترکیبی
miR-146a
miR-21
TLR-2

موضوعات

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end
فیزیولوژی ورزشی
دوره 17، شماره 67
پاییز 1404
صفحه 17-46

  • تاریخ دریافت 11 تیر 1403
  • تاریخ بازنگری 10 خرداد 1404
  • تاریخ پذیرش 19 خرداد 1404