The Responses of Fibrinolytic Factors to Different Resistance Exercise Protocols

Document Type : Research Paper

Authors

1 Associate Professor of Sport Physiology, Shahid Beheshti University

2 M.Sc. of Sport Physiology, Shahid Beheshti University

3 Assistant Professor of Sport Physiology, Khorramshahr University of Marine Science and Technology

Abstract

The purpose of this study was to investigate the responses of fibrinolytic factors to different resistance exercise protocols. Ten healthy male subjects (age, 24.7±2.2 yrs; height, 177±7 cm; and weight, 77±7 kg) familiar with weight training participated in four separate trials one week apart. After determining the maximal strength at the first session, subjects performed three resistance exercise protocols randomly at the 2nd, 3rd and 4th session including endurance-strength (3 sets, 15 reps at 55% one repetition maximum (1-RM) with 1 min rest), hypertrophy (3 sets, 10 reps at 70% 1-RM with 2 min rest) and strength (3 sets, 4-5 reps at 85% of 1-RM with 2 min rest). For measuring tissue plasminogen activator (t-PA) and plasminogen activator inhibitor one (PAI-1) blood samples were taken before and immediately after exercise. The results showed that resistance exercise protocols resulted in significant increases in t-PA levels (P=0.007), while the PAI-1 levels did not change significantly (P=0.529). Comparing the changes among the sessions showed that increases in t-PA following endurance-strength protocol was higher compared to the other two protocols. Based on the findings of the present study, it could be concluded that resistance exercise increases activity of fibrinolytic system and reduces the thrombus formation, and that these effects are more pronounced in the endurance-strength protocol.

Keywords

Main Subjects

References

  1. El-Sayed M, Jones P, Sale C. Exercise induces a change in plasma fibrinogen concentration: Fact or Fiction? Thromb Res. 1999; 96(6):467-72.
  2. Ernst E. Fibrinogen as a cardiovascular risk factor--interrelationship with infections and inflammation. Eur Heart J. 1993;14: 82-7.
  3. Lee K, Lip G. Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity: a systematic review. Arch Intern med. 2003;163(19):2368-92.
  4. 4.Takada A. The physiological aspects of fibrinolysis. Thromb Res. 1994;76(1):1-31.
  5. El-Sayed M, Ali Z, Ahmadizad S. Exercise and training effects on blood haemostasis in health and disease: an update. Sports Med. 2004;34(3):181-200.
  6. Seeley RR, Stephens T, Tate P. Essentials of anatomy & physiology. Mc Graw Hill; 2005. Chapter 11, 311-3.
  7. El-Sayed MS, Sale C, Jones PG, Chester M. Blood hemostasis in exercise and training. Med Sci Sports Exerc. 2000; 32: 918-25.
  8. Su-Jin S, Su-Ji K, Hyo-Wook G, Jong-Oh Y, Eun-Young L, Sae-Yong H. Tissue plasminogen activator and plasminogen activator inhibitor-1 levels in patients with acute paraquat intoxication. J Korean Med Sci. 2011; 26: 474-81.  
  9. Hau C, Kwaan MD. The fibrinolytic system. Northwestern.1974: 26: 65-72.
  10. Andrews RK, Berndt MC. Platelet physiology: In cold blood. Curr Biol. 2003; 13(7): 282-4.
  11. Brommer E, Gevers Leuven J, Brakman P. Lifestyle, fibrinolysis and lipids. Pharm World Sci. 1997; 19(2): 82-8.
  12. Baynard T, Jacobs H, Kessler C, Kanaley J, Fernhall B. Fibrinolytic markers and vasodilatory capacity following acute exercise among men of differing training status. Eur J Appl Physiol. 2007; 101(5): 595-602.
  13. Womack CJ, Ivey FM, Gardner AW, Macko RF. Fibrinolytic response to acute exercise in patients with peripheral arterial disease. Med Sci Sports Exerc. 2001; 33(2): 214-9.
  14. Fernhall B, Szymanski L, Gorman P, Milani J, Paup D, Kessler C. Fibrinolytic activity is not dependent upon exercise mode in post-myocardial infarction patients. Eur J Appl Physiol. 1998; 78(3): 247-52.
  15. Ribeiro J, Almeida-Dias A, Ascensao A, Magalhães J, Oliveira A, Carlson J, et al. Hemostatic response to acute physical exercise in healthy adolescents. J Sci Med Sport. 2007; 10(3): 164-9.
  16. El-Sayed M. Fibrinolytic and hemostatic parameter response after resistance exercise. Med Sci Sports Exerc.1993; 25(5): 597-602.
  17. Ahmadizad S, El-Sayed M. The effects of graded resistance exercise on platelet aggregation and activation. Med Sci Sports Exerc.2003; 35(6): 1026-32.
  18. Kraemer W, Ratamess N. Fundamentals of resistance training: Progression and exercise prescription. Med Sci Sports Exerc. 2004; 36(4): 674-88.
  19. Smilios I, Pilianidis T, Karamouzis M, Tokmakidis Sf. Hormonal responses after various resistance exercise protocols. Med Sci Sports Exerc. 2003; 33(4):        644-54.
  20. Azimpour M, Shahdadi A. Response of coagulation indices to two types of exercise of eccentric and isometric in male bodybuilding athletes. Qom Univ Med Sci J. 2016; 10(2): 13-21. (In Persian).
  21. Nascimento Dda C, Neto FR, de Santana FS, da Silva RA, Dos Santos-Neto L, Balsamo S. The interactions between hemostasis and resistance training: a review. Int J Gen Med. 2012; 5: 249-54.
  22. Amini A, Kordi M, Gayeni A, Ahmadi A, Veysi K. Effect of resistance exercise on coagulation and fibrinolytic factors in inactive aged men. Horizon Med Sci 2012; 3(18): 25-32. (In Persian).
  23. Brzycki M. Strength testing: predicting a one-rep max from repetitions to fatigue. J Phys Edu Recr Dance. 1993; 64: 88-90.
  24. Kupchak BR, Creighton BC, Aristizabal JC, Dunn-Lewis C, Volk BM, Ballard KD, et al. Beneficial effects of habitual resistance exercise training on coagulation and fibrinolytic responses. Thromb Res. 2013; 131(6): 227-34.
  25. Weiss C, Seitel G, Bartsch P. Coagulation and fibrinolysis after moderate and very heavy exercise in healthy male subjects. Med Sci Sports Exerc. 1998; 30(2): 246-51.
  26. Menzel K, Hilberg T. Coagulation and fibrinolysis are in balance after moderate exercise in middle-aged participants. Clin Appl Thromb Hemost. 2009; 15(3): 348-55.
  27. Hilberg T, Prasa D, Stürzebecher J, Gläser D, Schneider K, Gabriel HH. Blood coagulation and fibrinolysis after extreme short-term exercise. Thromb Res. 2003; 109(5-6): 271-7.
  28. Sumann G, Fries D, Griesmacher A, Falkensammer G, Klingler A, Koller A, et al. Blood coagulation activation and fibrinolysis during a downhill marathon run. Blood Coagul Fibrinol, 2007; 18(5): 435-40.
  29. Van der Bom JG, Bots M L, Haverkate F, Kluft C, Grobbee DE. The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma     PAI-1. Blood. 2003; 101: 1841-4.
  30. Brown NJ, Agirbasli MA, Williams GH, Litchfield WR, Vaughan DE. Effect of activation and inhibition of the ennin-angiotensin system on plasma PAI-1. Hypertension. 1998; 32: 965-71.
  31. Menzel K, Hilberg T. Blood coagulation and fibrinolysis in healthy, untrained subjects: effects of different exercise intensities controlled by individual anaerobic threshold. Eur J Appl Physiol. 2011; 111(2): 253-60.
  32. De Mello Meirelles C, Chagas Gomes PS. Acute effect of resistance exercise on energy expenditure revisiting the empact of the training variables. Revista Brasil de Med do Esporte. 2004; 10(2): 122-30.
  33. Amini A, Kordi MR, Gaini AA, Ahmadi A, Veysi K. Effect of resistance exercise on coagulation and fibrinolytic factors in inactive aged men. Horizon Med Sci. 2012; 18(3): 103-8.
Sport Physiology
Volume 10, Issue 37
Spring 2018
April 2018
Pages 139-152

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History

  • Receive Date: 18 October 2016
  • Revise Date: 12 January 2017
  • Accept Date: 06 February 2017

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