In accordance with the limited and conflicting results about the effects dietary supplements on exercise-induced inflammatory responses, the present study was conducted to identify the effect of acute different doses caffeine intake on the response of C-reactive protein (CRP) and peripheral blood leucocytes by following singleexhaustive resistance training in male volleyball players. Thirty male volleyball players (aged 21.47±1.45 years, fat 10.47±3.11%, and BMI 23.15±1.26 kg.m²) in a semi-experimental, randomized and double-blind design were allocated equally into three randomized homogeneous groups: two supplement groups (with Caffeine intake: 6 or 9 mg.kg^-1) and placebo group (Dextrose intake: 6 mg.kg^-1). After the acute supplementation, subjects were participated in a single-session resistance weight-training (with 80% of one repetition maximum until exhaustive). Changes in serum CRP and peripheral blood leukocytes counts were determined in three phases (Baseline, 45 min after the supplementation and 24 hours after the training protocol).The normal data were analyzed by repeated measure ANOVA and Bonferroni at α≤0.05. The results show that the acute different doses of caffeine ingestion has significantly increase (P<0.05) on the basal inflammatory indices. Moreover, the 24-hour response of serum CRP and peripheral blood leukocytes counts following the resistance training in caffeine groups were significantly less than placebo group (P<0.05). Based on the present findings can be concluded that acute different doses of caffeine intake can probably to reduce exercise-induced inflammatory response (CRP elevation and Leukocytosis) following a single-session resistance training in male volleyball players.