تاثیر تمرینات ‌هوازی قبل از بارداری و فعالیت‌بدنی حین بارداری بر استرس اکسیداتیو در بافت‌های رحم و تخمدان رت‌های مادر پس از زایمان

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه زنجان، زنجان، ایران

10.22089/spj.2025.17531.2343
چکیده
اهداف: مطالعه تأثیر تمرین هوازی قبل از بارداری و فعالیت بدنی حین بارداری بر سطوح GPX ، SOD ، TAC و MDA بافت رحم و تخمدان رت‌های مادر پس از زایمان
مواد و روش‌ها: 48 سر موش ماده 8 هفته‌ای به طور تصادفی در دو گروه تجربی و کنترل قرار گرفته و گروه تجربی به مدت 6 هفته با 70-60 درصد VO2max به انجام تمرینات هوازی روی تردمیل پرداختند. پس از جفت‌گیری و احراز بارداری از طریق مشاهده اولین پلاک واژینال، موش‌های دو گروه مجدداً به دو گروه تمرینی و غیر تمرینی تقسیم شده و گروه تمرینی به مدت سه هفته با 45-35 درصد VO2max فعالیت بدنی انجام دادند. سه هفته پس از زایمان، نمونه‌برداری برای سنجش شاخص‌های استرس‌اکسایشی انجام شد. داده ها با استفاده از آزمون تحلیل واریانس و آزمون تعقیبی گابریل در نرم افزار spss24 تحلیل شد.
یافته‌ها: نتایج نشانگر افزایش معنی‌دار سطوحTAC ، GPX و SOD بافت تخمدان گروه تمرین هوازی قبل از بارداری و همچنین سطح TAC گروه تمرین هوازی قبل از بارداری و فعالیت بدنی حین بارداری نسبت به گروه کنترل بود. در بافت رحم نیز افزایش قابل توجهی در سطح آنزیم GPX گروه تمرین هوازی قبل از بارداری مشاهده شد.
نتیجه‌گیری: به نظر می‌رسد تمرین هوازی قبل از بارداری تأثیر بیشتری بر سازگاری سیستم استرس‌اکسیداتیو داشته و منجر به بهبود عملکرد آنتی‌اکسیدانی بافت رحم و تخمدان می‌شود که در نهایت می‌تواند بر سلامت و بهبود عملکرد این بافت‌ها تأثیر بگذارد.

کلیدواژه‌ها

موضوعات


  1. منابع

    1. Duhig K, Chappell LC, Shennan AH. Oxidative stress in pregnancy and reproduction. Obstetric Medicine. 2016;9(3):113-6.
    2. Luo ZC, Fraser WD, Julien P, Deal CL, Audibert F, Smith GN, et al. Tracing the origins of “fetal origins” of adult diseases: programming by oxidative stress? Medical Hypotheses, 2006;66(1):38-44.
    3. Aghadavod E, Nasri H. What are the molecular mechanisms of oxidant and antioxidant compounds? Annals of Research in Antioxidants. 2016;1(1):e10.
    4. Poljsak B, Šuput D, Milisav I. Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxidative Medicine and Cellular Longevity. 2013;2013:1-11.
    5. Nocella C, Cammisotto V, Fianchini L, D'Amico A, Novo M, Castellani V, et al. Extra virgin olive oil and cardiovascular diseases: benefits for human health. Endocrine, Metabolic & Immune Disorders-Drug Targets. 2018;18(1):4-13.
    6. Michailidis Y, Karagounis LG, Terzis G, Jamurtas Az, Spengos K, Tsoukas D, et al. Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise. The American Journal of Clinical Nutrition. 2013;98(1):233-45.
    7. Ono H, Sakamoto A, Sakura N. Plasma total glutathione concentrations in healthy pediatric and adult subjects. Clinica Chimica Acta. 2001;312(1-2):227-9.
    8. Harman D. Aging: a theory based on free radical and radiation chemistry. Science of Aging Knowledge Environment. 2002;2002(37)cp14.
    9. Abuelghar WM, Elkady OS, Khamees AA. Clomiphene citrate alone, in combination with metformin or in combination with pioglitazone as first line therapy in induction of ovulation in infertile women with polycystic ovary syndrome, a randomized controlled trial. Middle East Fertility Society Journal. 2013;18(3):135-41.
    10. Johnson DA. Gastroenterologic issues in the obese patient. In: An issue of gastroenterology clinics. Edinburge: Elsevier Health Sciences; 2010, pp. 1-7.
    11. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reproductive Biology and Endocrinology. 2005;3:1-21.
    12. Barik G, Chaturvedula L, Bobby Z. Role of oxidative stress and antioxidants in male infertility: An interventional study. Journal of Human Reproductive Sciences. 2019;12(3):204-9.
    13. Shephard RJ, Verde TJ, Thomas SG, Shek P. Physical activity and the immune system. Canadian Journal of Sport Sciences= Journal Canadien des Sciences du Sport. 1991;16(3):169-85.
    14. Dos Santos Cunha WD, Giampietro MV, De Souza DF, Vaisberg M, Seelaender MC, Rosa LF. Exercise restores immune cell function in energy-restricted rats. Medicine and Science in Sports and Exercise. 2004;36(12):2059-64.
    15. Padilha CS, Ribeiro AS, Fleck SJ, Nascimento MA, Pina FL, Okino AM, Venturini D, Barbosa DS, Mayhew JL, Cyrino ES. Effect of resistance training with different frequencies and detraining on muscular strength and oxidative stress biomarkers in older women. Age. 2015;37:1-9.
    16. Ye Y, Lin H, Wan M, Qiu P, Xia R, He J, et al. The effects of aerobic exercise on oxidative stress in older adults: a systematic review and meta-analysis. Frontiers in Physiology. 2021;12:701151.
    17. Ketabipoor SM, Koushkie Jahromi M. Effect of aerobic exercise in water on serum estrogen and C-Reactive protein and body mass index level in obese and normal weight postmenopausal women. Women’s Health Bulletin. 2015;2(3):1-6.
    18. Jarrete AP, Novais IP, Nunes HA, Puga GM, Delbin MA, Zanesco A. Influence of aerobic exercise training on cardiovascular and endocrine-inflammatory biomarkers in hypertensive postmenopausal women. Journal of Clinical & Translational Endocrinology. 2014;1(3):108-14.
    19. Chae CH, Jung SL, An SH, Jung CK, Nam SN, Kim HT. Treadmill exercise suppresses muscle cell apoptosis by increasing nerve growth factor levels and stimulating p-phosphatidylinositol 3-kinase activation in the soleus of diabetic rats. Journal of Physiology and Biochemistry. 2011;67:235-41.
    20. Chae CH, et al. Treadmill exercise improves cognitive function and facilitates nerve growth factor signaling by activating mitogen-activated protein kinase/extracellular signal-regulated kinase1/2 in the streptozotocin-induced diabetic rat hippocampus. 2013;231:445.
    21. Høydal MA, Wisløff U, Kemi OJ, Ellingsen Ø. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. European Journal of Preventive Cardiology. 2007;14(6):753-60.
    22. Ezmerli NM. Exercise in pregnancy. Primary Care Update for Ob/Gyns. 2000;7(6):260-5.
    23. Zhang H, Jiang L, Ye S, Ye Y, Ren F. Systematic evaluation of antioxidant capacities of the ethanolic extract of different tissues of jujube (Ziziphus jujuba ) from China. Food and Chemical Toxicology. 2010;48(6):1461-5.
    24. Arthur J, Boyne R. Superoxide dismutase and glutathione peroxidase activities in neutrophils from selenium deficient and copper deficient cattle. Life Sciences. 1985;36(16):1569-75
    25. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of laboratory and Clinical Medicine. 1967;70(1):158-69.
    26. Aebi H. Catalase in vitro. In: Methods in enzymology. Vol. 105. Cambridge: Academic Press; 1984, pp. 121-6.
    27. Miller NJ, Rice-Evans C, Davies MJ, Gopinathan V, Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clinical Science. 1993;84(4):407-12.
    28. Soares JP, Silva AM, Oliveira MM, Peixoto F, Gaivão I, Mota MP. Effects of combined physical exe rcise training on DNA damage and repair capacity: role of oxidative stress changes. Age. 2015;37:1-2
    29. Parise G, Phillips SM, Kaczor JJ, Tarnopolsky MA. Antioxidant enzyme activity is up-regulated after unilateral resistance exercise training in older adults. Free Radical Biology and Medicine. 2005;39(2):289-95.
    30. Aksoy Y, Yapanoğlu T, Aksoy H, Demircan B, Öztaşan N, Canakci E, Malkoc I. Effects of endurance training on antioxidant defense mechanisms and lipid peroxidation in testis of rats. Archives of Andrology. 2006;52(4):319-23.
    31. Kadkhodaei Khalafi M, Dabidi Roshan V, Beyranvand MR. Response of the cardiovascular physiological and functional markers following the short term taurine supplementation and burce protocol in patients with cardiac heart failure. Razi Journal of Medical Sciences. 2011;18(84):28-37.
    32. Liberali R, Wilhelm Filho D, Petroski EL. Aerobic and anaerobic training sessions promote antioxidant changes in young male soccer players. MedicalExpress. 2016;3:M160107.
    33. Ugras AF. Effect of high intensity interval training on elite athletes’ antioxidant status. Science & Sports. 2013;28(5):253-9.
    34. Farida S. Influence de l'environnement (exercice et nutrition) durant la gestation sur l’état de stress oxydant et le métabolisme du glucose de la descendance (Master's thesis). Universitas Indonesia, 2016
    35. Okudan N, Belviranli M, Torlak S. Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men. J Sports Med Phys Fitness. 2018;58(6):889-894.
    36. Mohammadi E, Nikseresht F. Effect of 8 Weeks of Incremental Endurance Training on Antioxidant Enzymes and Total Antioxidant Status of Cardiac Tissue in Experimental Diabetic Rats. Journal of Shahid Sadoughi University of Medical Sciences. 2020;28(3):2490-2501.
    37. Naghizadeh H, Afzalpour ME, Zarban A. The comparison of antioxidant status and lipid profile of karate athletes with non-athletes. Journal of Birjand University of Medical Sciences. 2009;16(3):54-61.
    38. Rami M, Habibi A, Khajehlandi M. The effect of moderate intensity exercise on the activity of catalase enzyme and malondialdehyde in hippocampus area of diabetic male Wistar rats. Feyz Medical Sciences Journal. 2018;22(6):555-63.
    39. Guo S, Huang Y, Zhang Y, Huang H, Hong S, Liu T. Impacts of exercise interventions on different diseases and organ functions in mice. Journal of Sport and Health Science. 2020 Jan 1;9(1):53-73.
    40. Peeri M, Azarbayjani M, Akbarpour M, Ebrahimi M. The effect of aerobic training on the immune system of aging men. Annals of Biological Research. 2011;2(5):299-304.
    41. Qasemnia AA, Zighami Z, Hadi S. The effect of eight weeks of increased aerobic exercise with zinc supplementation on muscle superoxide dismutase activity and serum leptin levels and weight changes in adult wistar rats. Armaghane Danesh. 2019;24(6):1054-72.
    42. Sutkowy P, Augustyńska B, Woźniak A, Rakowski A. Physical Exercise combined with whole‐body cryotherapy in evaluating the level of lipid peroxidation products and other oxidant stress indicators in kayakers. Oxidative Medicine and Cellular Longevity. 2014;2014(1):402631.
    43. Watson TA, MacDonald-Wicks LK, Garg ML. Oxidative stress and antioxidants in athletes undertaking regular exercise training. International Journal of Sport Nutrition and Exercise Metabolism. 2005;15(2):131-46.
    44. Usefpor M, Ghasemnian AA, Rahmani A. The effect of a period of high intensive interval training on total antioxidant capacity and level of liver tissue malondialdehyde in male Wistar rats. Scientific Journal of Kurdistan University of Medical Sciences. 2017;22(5):103-10.
    45. Speich M, Pineau A, Ballereau F. Minerals, trace elements and related biological variables in athletes and during physical activity. Clinica Chimica Acta. 2001;312(1-2):1-1.
    46. Fatahi A, Azizbiegi K, Ranjbar K, Mohammadzade K. The protective effect of high intensity interval training preconditioning on ischemia reperfusion-injury in ageing rats. Internal Medicine Today. 2019;25(1):22-8.
    47. Bloomer RJ, Goldfarb AH, McKenzie MJ. Oxidative stress response to aerobic exercise: comparison of antioxidant supplements. Medicine & Science in Sports & Exercise. 2006;38(6):1098-105.
    48. Choi EY, Cho YO. The effects of physical training on antioxidative status under exercise-induced oxidative stress. Nutrition Research and Practice. 2007;1(1):14-8.
    49. Karandish M, Rahideh ST, Zand-Moghaddam A, Haghighizadeh MH. Effect of vitamin c supplementation on oxidative stress markers following 30 minutes moderate intensity exercise in healthy young women. Iranian Journal of Endocrinology and Metabolism. 2008;10(2):127-32.
    50. Goldfarb AH, McKenzie MJ, Bloomer RJ. Gender comparisons of exercise-induced oxidative stress: influence of antioxidant supplementation. Applied Physiology, Nutrition, and Metabolism. 2007;32(6):1124-31.

    Yeylaghi Ashrafi M, Dabidi Roshan V. Aerobic and anaerobic exercise of the acute and chronic and the selected markers of oxidative stress: a systematic review in human and animal studies. Journal of Sabzevar University of Medical Sciences. 2016;22(Special Issue):1126-38.

  • تاریخ دریافت 20 آذر 1403
  • تاریخ بازنگری 25 اسفند 1403
  • تاریخ پذیرش 26 اسفند 1403