Document Type : Research Paper

Authors

Abstract

The aim of this study was to investigate the effect of long-term L-carnitine supplementation and endurance training on the blood lipid profile and plasma levels of lipoprotein lipase. In this semi experimental study, 20 non-athlete students randomly divided into two groups of supplementation (n = 10, mean age 20.1±0.9 years, weight 74.2±2.5 kg, height 176.1±4.8cm) and placebo (n = 10, mean age 20.1±0.6 years, weight 67.7±4.6 kg, height 177.7±4.6cm), respectively. HDL, total cholesterol (TC), LDL, VLDL, lipoprotein lipase, RF and body fat percentage evaluated for a period of six weeks and 3 days a week. of training according to the principle of overload. The intensity training 65-75% Maximum heart rate each subjects. During this period the group supplementation used 13mg of L-Carnitine per each kilogram of body weight and the group placebo used just 3 mg of starch per each kilogram of their body weight. The two groups were studied before and after training for TG, TC, HDL, LDL, VLDL, RF as well as lipoprotein lipase. The data analyzed using SPSS-20 and independent and dependent T student test. Our findings showed a significant increase in HDL (P<0.05) and decrease in TC, body fat percentage of the group supplementation (P<0.05), but considering the BMI and the amount of TG, LDL, VLDL, RF and lipoprotein lipase there was no significant change observed. Based on the finding of this study, we can say that if young people use L-Carnitine besides their aerobic training this may increase their HDL and decrease TC, and body fat. But for the effects on lipid parameters and lipoprotein lipase in L-Carnitine use besides aerobic training we need more research.

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1) Karlic H, Lohnonger A. Supplementation of L-canitine in athletes. Does It Make Sense? J Nutrition. 2004; 20: 709-15. 
2) Nieman D C, Brock D W, Butterworth D, Utter A C, Nieman C C. Reducing diet and/or exercise training decreases the lipid and lipoprotein risk factors of moderately obese women. J Am College Nutr. 2002; 21: 344-50. 
3) Broad E M, Maughan R J, Galloway S D. Carbohydrate, protein, and fat metabolism during exercise after oral Carnitine supplementation in humans. Int J Sport Nutr Exerc Metab 2008; 18(6): 567-84.
4) Gomes M R, Tirapegui J. Relation of some nutritional supplements and physical performance. Arch Latinoam Nutr. 2000; 50(4): 317-29.
5) Guarnieri G, Biolo G, Vinci P, Massolino B, Barazzoni R. Advances in carnitine in chronic uremia. J Ren Nutr. 2007; 17(1): 23-9.
6) Donahoo W T, Jensen D R, Shepard T Y, Eckel R H. Seasonal variation in lipoprotein lipase and plasma lipids in physically active, normal weight humans. J Clin Endocrinol Metab 2000; 85: 3065-8. 
7) Atanassova P, Delchev S, Georgieva K, Koeva Y. Lipoprotein lipase enzyme histochemical activity in subcutaneous adipose tissue and skeletal muscle of the rat after submaximal exercise training. J Conference of Biol. 2005; 21(5): 263-8. 
8) Paulin A, Lalonde J, Deshaies Y. Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise. Am J Physiol. 1991; 261(4): 891-7.
9) Magnoni L, Weber J M. Endurance swimming activates trout lipoprotein lipase: Plasma lipids as a fuel for muscle. J Experim Biol. 2007; 210: 4016-23.
10) Murosaki S, Lee T R, Muroyama K, Shin E S. A combination of caffeine, arginine, soy isoflavones, and L-carnitine enhances both lipolysis and fatty acid oxidation in 3T3-L1 and HepG2 cells in vitro and in KK mice in vivo. J Nutr. 2007; 137(10): 2252-7.
11) Spiering B A, Kraemer W J, Hatfield D L, Vingren JL, Fragala MS, Ho JY, et al. Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise. J Strength Cond Res. 2008; 22(4): 1130-5.
12) Lee M S, Lee H J, Lee H S, Kim Y. L-caintine stimulates lipolysis via induction of the lipolytic gene express and suppression of the adipogenic gene express in 3T3-L1 adipocytes. J Med Food. 2006; 9(4): ­468-73.
13) Rajasekar P, Anuradha C V. Effect of Lcarnitine on skeletal muscle lipids and oxidative stress in rats fed high-fructose diet. Exp Diabetes Res. 2007; 10(8): 727-41.
14) Wutzke K D, Lorenz H. The effect of L-canintine on fat oxidation, protein turnover, and body composition in slightly overweight subjects. Metabolism; 2004; 53(10) : 1002-6.
15) Bernard A, Rigault C, Mazua F, Borgne F, Demarquoy J. Lcarnitine supplementation and physical exercise restore in some mitochondrial function in the Rat. J of Gerontology. 2008; 63: 1027-33. 
16) هوانلو فریبرز، نورشاهی مریم، امینی احسان، سهامی مینا. تأثیر مکمل­دهی کوتاه­مدت ال-کارنیتین و کوآنزیم Q10 بر عملکرد هوازی و بی­هوازی مردان غیر­فعال. نشریۀ علوم پزشکی شهید بهشتی. 1391؛ 17(1): 17ـ8.
17) حقیقی امیرحسین، فروغیان مهدی، حامدی­نیا محمدرضا، چمری مریم. تأثیر 6 هفته تمرین هوازی و مکمل ال-کارنیتین بر درصد چربی بدن و نیم­رخ لیپیدی سرم مردان فعال. نشریۀ علوم زیستی ورزشی. 1389؛ 7(6): 58ـ41.
18) تد­ای بوام گارتنر، اندارواس جکسون، میتونی ماهار، دیوید ای رو. اندازه­گیری برای ارزشیابی در تربیت­بدنی و علوم ورزشی. مترجمان: سپاسی حسین، نوربخش پریوش. چاپ اول. تهران: انتشارات سمت؛ 1390. ص 6ـ415.
19) Brass E P. Supplemental carnitine and exercise. Am J Clinic Nutri. 2002; 72(2):          618-23.
20) حکیمی مهدی، شیخ­الاسلامی وطنی داریوش، ­علی­محمدی مریم. مقایسۀ اثر 8 هفته تمرینات مقاومتی با ترکیبی (مقاومتی ـ ماساژ) بر لپتین سرم، نیم­رخ لیپیدی و ترکیب بدنی مردان جوان دارای اضافه­وزن. نشریۀ فیزیولوژی ورزشی. 1394؛ 7(25): 32ـ15.
21) Villani R G. Gannon J, Self M, Rich P A. L-canitine supplementation combined with aerobic training does promote weight loss in moderately obese women. Int Sport Nutr Exerc Metab. 2000; 10: 199. 
22) 22. Lofgren I E, Herron K L, West K L, Zern T L, Brownbill R A, Ilich J Z, et al. Weight loss favorably modifies anthropometrics and reversal the metabolic syndrome in premenopausal women. JACN. 2005; 24(6):­ 486-93.
23) فتحی رزیتا، نظرعلی پروانه، ادبی زهرا. تأثیر 8 هفته تمرین مقاومتی بر سطوح امنتین و شاخص مقاومت به انسولین در زنان چاق و دارای اضافه­وزن. نشریۀ فیزیولوژی ورزشی. 1393؛ 10(19): 20ـ109.
24) Panjwani U, Thakur L, Anand J P, Singh S N, Amitabh, Singh S B, et al. Effect of l-carnitine supplementation on endurance exercise in normobaric/ normoxic and hypobaric/ hypoxic conditions. Wilderness Environ Med. 2007; 18(3): 169-76.
25) Lim W Y, Chia Y Y, Liong S Y, Ton SH, Kadir K A, Husain S N. Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats. Lipids Health Dis. 2009; 8: 31. 
26) Cristiana P. L-carnitine health and disease. Am Rev respire dis. 2004; 112: 219-49.
27) Patalay M, Lofgren I E, Freake H C. The lowering of plasma lipids following a weight reduction program is related to increased expression of the LDL-receptor and lipoprotein lipase. J Nutr. 2005; 135: 735-9. 
28) Muller D M, Seim H, Kiess W, Loster H, Richter T. Effect of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Metabolism. 2002; 51(11): 1989-91.
29) مهربانی جواد، رمضانی نسرین، ایران­شاهی فرزانه. اثر تمرینات اینتروال هوازی بر سطوح خونی مالون دی آلدئید، ظرفیت ضداکسایشی تام و پروفایل لیپیدی در زنان غیرفعال. نشریۀ فیزیولوژی ورزشی. 1393؛ 6(22)؛ 94ـ81.
30) طاهری لیلا. تأثیر 8 هفته تمرین هوازی بر لیپوپروتئین­های خونی زنان غیر­ورزشکار شهر اهواز. نشریۀ حرکت. 1386؛ 9(1): 99ـ87.