Document Type : Research Paper

Authors

Abstract

The purpose of this study was the comparison effect of eight weeks continuous and interval training on PRO- BNP/CORIN system in coronary artery disease patients after CABG surgery.Methodology: 36 patients were selected purposive (27 men and 9 women with mean of age 60.32±5.81 year, height 164.64 ± 9.25 cm, weight 73.86±14.23 kg, fat 32.30±4.28, SBP 142.67± 6.49 , DBP 84.5±5.16 mmhg in seated position at rest situation and functional capacity of 7.08±2.49 METs) and then divided randomly into three groups: control (C) group (without training program) aerobic continuous (AC) training and aerobic interval (AI) training (exercise training program was performed 3 day/week for 8 weeks) with intensities 65% to 80% and 80% to 95% of reserve heart rate in order. 48 hours before the first session of training program and after the final training session blood samples were collected. wilcoxin and kruskal wallis tests were used for analyzing data. Results indicate that PRO-BNP is increased, CORIN is decreased and BNP also is decreased significantly in (C) group (P=0.005,0.012,0.003). In both (AC) and (AI) groups, PRO-BNP is decreased, CORIN is increased and BNP also is decreased but these variations was significant only in AI group (P=0.005,0.002,0.002). Between group analyze also indicated that there is significant difference between groups in variation of PRO-BNP, CORIN and BNP (P≤0.001). Conclusion: (AI) training in contrast of (AC) training is more effective in PRO-BNP/­­CORIN system development after CABG.

Keywords

Main Subjects

  1. Ghalamghash R, Goosheh B, Emrani A, Keyhani M R, Hosseini A. Effects of cardiac rehabilitation programs on functional capacity following valvular heart surgery. Journal of Cardiopulmonary Rehabilitation and Prevention. 2007; 27(5): 346-56. (In Persian).
  2. Siribaddana S. Cardiac dysfunction in the CABG patient. Current Opinion in Pharmacology. 2012; 12(2): 166-71.
  3. Badawy M A, Al Shammari F, Aleinati T, Eldin M S, Tarazi R, Alfadli J. Deep sternal wound infection after coronary artery bypass: How to manage? Asian Cardiovascular and Thoracic Annals. 2014;22(6): 649-54.
  4. Cockburn J, Blows L, Cohen A, Holmberg S, Hyde J, Lewis M, et al. Acute ischemic complications of PCI and CABG: Who should cover whom for coronary revascularization? Journal of Interventional Cardiology. 2013; 26(4): 370-9.
  5. Giles T D, Sander G E, Nossaman B D, Kadowitz P J. Impaired vasodilation in the pathogenesis of hypertension: Focus on nitric oxide, endothelial‐derived hyperpolarizing factors, and prostaglandins. The Journal of Clinical Hypertension. 2012; 14(4): 198-205.
  6. Dinh Q N, Drummond G R, Sobey C G, Chrissobolis S. Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. Bio Med Research International. 2014;22(7).1-11.
  7. From A M, Borlaug B A. Heart failure with preserved ejection fraction: Pathophysiology and emerging therapies. Cardiovascular Therapeutics. 2011; 29(4): 6-21.
  8. Ichiki T, Boerrigter G, Huntley B K, Sangaralingham S J, McKie P M, Harty G J, et al. Differential expression of the pro-natriuretic peptide convertases corin and furin in experimental heart failure and atrial fibrosis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2013; 304(2): 102-12.
  9. Zhou Y, Wu Q. Corin in natriuretic peptide processing and hypertension. Current Hypertension Reports. 2014; 16(2): 1-8.
  10. Ichiki T, Huntley B K, Heublein D M, Sandberg S M, McKie P M, Martin F L, et al. Corin is present in the normal human heart, kidney, and blood, with Pro–B-type natriuretic peptide processing in the circulation. Clinical Chemistry. 2011; 57(1): 40-57.
  11. Horio T, Kawano Y. Bio-molecular markers for cardiovascular disease: Significance of natriuretic peptides and adrenomedullin. Korean Circulation Journal. 2008; 38(10): 507-16.
  12. Rengo G, Pagano G, Parisi V, Femminella G D, de Lucia C, Liccardo D, et al. Changes of plasma norepinephrine and serum N-terminal pro-brain natriuretic peptide after exercise training predict survival in patients with heart failure. International Journal of Cardiology. 2014; 171(3): 384-91.
  13. Fox A A, Collard C D, Shernan S K, Seidman C E, Seidman J G, Liu K Y, et al. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Anesthesiology. 2009; 110(4): 738-48.
  14. Fox A A, Marcantonio E R, Collard C D, Thoma M, Perry T E, Shernan S K, et al. Elevated peak postoperative B-type natriuretic peptide predicts decreased longer-term physical function after primary coronary artery bypass graft surgery. Anesthesiology. 2011; 114(4): 807-17.
  15. Fox A A, Nascimben L, Body S C, Collard C D, Mitani A A, Liu K Y, et al. Increased perioperative B-type natriuretic peptide associates with heart failure hospitalization or heart failure death after coronary artery bypass graft surgery. Anesthesiology. 2013; 119(2): 650-8.
  16. Barnet C S, Liu X, Body S C, Collard C D, Shernan S K, Muehlschlegel J D, et al. Plasma corin decreases after coronary artery bypass graft surgery and is associated with postoperative heart failure: A pilot study. Journal of Cardiothoracic and Vascular Anesthesia. 2015; 29(2): 374-81.
  17. Broderick T L, Wang D, Jankowski M, Gutkowska J. Unexpected effects of voluntary exercise training on natriuretic peptide and receptor mRNA expression in the ob/ob mouse heart. Regulatory Peptides. 2014; 188(10): 52-9.
  18. Smart N A, Steele M. Systematic review of the effect of aerobic and resistance exercise training on systemic brain natriuretic peptide (BNP) and N-terminal BNP expression in heart failure patients. International Journal of Cardiology. 2010; 140(3): 260-75.
  19. Wisloff U, Stoylen A, Loennechen J P, Bruvold M, Rognmo O, Haram P M, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients a randomized study. Circulation. 2007; 115(24): 3086-94.
  20. Gademan M G, Swenne C A, Verwey H F, Van Der Laarse A, Maan A C, Van De Vooren H, et al. Effect of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure. Journal of Cardiac Failure. 2007; 13(4): 294-303.
  21. Meyer P, Gayda M, Juneau M, Nigam A. High-intensity aerobic interval exercise in chronic heart failure. Current Heart Failure Reports. 2013; 10(2): 130-8.
  22. Guiraud T, Nigam A, Gremeaux V, Meyer P, Juneau M, Bosquet L. High-intensity interval training in cardiac rehabilitation. Sports Medicine. 2012; 42(7): 587-605.
  23. Normandin E, Nigam A, Meyer P, Juneau M, Guiraud T, Bosquet L, et al. Acute responses to intermittent and continuous exercise in heart failure patients. Canadian Journal of Cardiology. 2013; 29(4): 466-71.
  24. Thow M. Exercise leadership in cardiac rehabilitation: An evidence-based approach. 1th ed. Glasgow. John Wiley & Sons; 2006. P. 23.
  25. Eston R, Reilly T. Kinanthropometry and exercise physiology laboratory manual: Anthropometry. 1th ed. Liverpool. Taylor & Francis; 2009. P. 31-5.
    1. Sagiv M S. Exercise cardiopulmonary function in cardiac patients. Translators: Gaeini A A, Hemmati Nafar M, Ahmadi M, Khodaei M, Zare Karizak S, Bahramian A. 1th ed.tehran. Bamdad Publication; 2012. P. 427. (In Persian).
  26. Dietz T, Kalof L. Introduction to social statistics: The logic of statistical reasoning. 1th ed. Newyork. John Wiley & Sons; 2009. P. 237.
  27. Macheret F, Boerrigter G, McKie P, Costello-Boerrigter L, Lahr B, Heublein D, et al. Pro–B-type natriuretic peptide1–108 circulates in the general community: Plasma determinants and detection of left ventricular dysfunction. Journal of the American College of Cardiology. 2011; 57(12): 1386-95.
  28. Passino C, Severino S, Poletti R, Piepoli M F, Mammini C, Clerico A, et al. Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure. Journal of the American College of Cardiology. 2006; 47(9): 1835-49.
  29. Dessì-Fulgheri P, Sarzani R, Tamburrini P, Moraca A, Espinosa E, Cola G, et al. Plasma atrial natriuretic peptide and natriuretic peptide receptor gene expression in adipose tissue of normotensive and hypertensive obese patients. Journal of Hypertension. 1997; 15(12): 1695-708.
  30. Arora P, Reingold J, Baggish A, Guanaga D P, Wu C, Ghorbani A, et al. Weight loss, saline loading, and the natriuretic peptide system. Journal of the American Heart Association. 2015; 4(1): 1265-73.
  31. Marney A M, Brown N J, Tamboli R, Abumrad N. Changes in B-type natriuretic peptide and BMI following roux-en-Y gastric bypass surgery. Diabetes Care. 2014; 37(4): 70-8.
  32. Huntley B K, Sandberg S M, Heublein D M, Sangaralingham S J, Burnett J C, Ichiki T. Pro–B-type natriuretic peptide-1-108 processing and degradation in human heart failure. Circulation: Heart Failure. 2015; 8(1): 89-97.
  33. Wang T J, Larson M G, Levy D, Leip E P, Benjamin E J, Wilson P W, et al. Impact of age and sex on Plasma natriuretic peptide levels in healthy adults. The American Journal of Cardiology. 2002; 90(3): 254-68.