Sport Physiology

Sport Physiology

Effects of Eight-Weeks Aerobic Exercise on Leptin to Adiponectin Ratio and Glycemic Control Indices in Men with Type 2 Diabetes

Document Type : Research Paper

Authors
Hamid Ahmadi 1
Mohsen Ghanbarzadeh 2
Masood Nikbakht 3
rouhollah ranjbar 3
1 Ph.D. student, Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 Assistant Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
10.22089/spj.2021.10260.2122
Abstract
The aim of this study was to evaluate the effect of eight weeks of aerobic exercise on leptin to adiponectin (L/A) ratio and glycemic control indices in type 2 diabetic patients. Among men with type 2 diabetes, 24 person [mean age (48.7 ± 0.71 years) and BMI (30.7 ± 3.3 kg / m2)] randomly divided into two groups of aerobic exercise (n = 12) and control group (n = 12). The aerobic exercise program was performed as eight weeks of running, five sessions per week, for one hour with an intensity of 50 to 75% of the HRR. Leptin, adiponectin, L/A ratio, HbA1c, plasma glucose, insulin, HOMA-IR and insulin sensitivity were measured in pretest and posttest. Analysis of covariance and Pearson correlation tests were used to analyze the data. The results of the intergroup test showed that plasma leptin levels and L/A ratio decreased and adiponectin levels increased significantly compared to the control group (P <0.05). Moreover, insulin, glucose, HbA1c and HOMA-IR levels in the aerobic exercise group decreased compared to the control group and the level of insulin sensitivity increased significantly compared to the control group (P <0.05). Despite these results, the correlation test indicated no significant relationship between L/A ratio with glycemic control indices (P> 0.05). The improvement in L/A appears to be due to the effect of aerobic exercise on changes in BMI and fat percentage; however, the improvement mechanism of glycemic control indices probably has other pathways than adipokines that need to be studied
Keywords
Aerobic exercise
Type 2 diabetes
Leptin to adiponectin Ratio
Glycemic control indices
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  • Receive Date 13 March 2021
  • Revise Date 16 August 2021
  • Accept Date 24 August 2021