Sport Physiology

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Editorial Board

Article Processing Charges (APC)

Indexing and Abstracting

Related Links

FAQ

Reviewers

Terms and conditions for manuscript submission

Submission Instruction

Forms

Peer Review Process

Comparison the Effect of two type resistance training on Metabolism ceramide and insulin sensitivity in overweight and obese young men

Document Type : Research Paper

Authors

1 PhD Student in Sports Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar

2 Professor in Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar

3 3. Associate Professor in Exercise Physiology, Faculty of Humanities, Ilam University, Ilam

4 Assistant professor of Exercise Physiology, Faculty of Humanities, Semnan University, Semnan

Abstract

Ceramides are a family of fat molecules that play an important role in glucose homeostasis and insulin signaling. The aim of this study was to compare the effect of two methods of resistance training on ceramide metabolism and insulin sensitivity in overweight and obese young men. 33 overweight and obese men (age: 17.7 ± 0.13 years, weight: 92 ± 2.45 kg, BMI: 30.70 ± 1.32 kg/m2) were selected and randomly divided into three groups. The training program consisted of 12 weeks of traditional and circular resistance training that was exactly the same size and pattern as the wave, which was performed three sessions per week. Blood samples were gathered after 8 hours of fasting and 48 hours before and after the last training program. HPLC method was used to measure serum ceramide levels. The results showed There was no significant difference between the two resistance training protocols in serum ceramide (p = 0.71) and insulin sensitivity (p = 0.47). Two circular and traditional exercises with significant changes in lipid profile and significant increase in insulin sensitivity levels (p = 0.008), (p = 0.001) respectively. But decrease in ceramide (p = 0.001) was observed only in circular exercises. According to the results of the present study, that serum lipid and ceramide profile levels decreased during circular resistance training with increasing insulin sensitivity. And this decrease may indicate a decrease in metabolic risk factors.

Keywords

References
  1. Ofei F. Obesity-a preventable disease. Ghana Medical Journal. 2005;39(3):98.
  2. Kelly T, Yang W, Chen C-S, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. International Journal of Obesity. 2008;32(9):1431-7.
  3. Ogunbode A, Ladipo M, Ajayi I, Fatiregun A. Obesity: an emerging disease. Nigerian Journal of Clinical Practice. 2011;14(4):390-4.
  4. Lin Y, Sun Z. Current views on type 2 diabetes. The Journal of Endocrinology. 2010;204(1):1.
  5. Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovascular Diabetology. 2018;17(1):1-14.
  6. Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. Journal of Biological Chemistry. 2002;277(52):50230-6.
  7. Ogretmen B. Sphingolipid metabolism in cancer signalling and therapy. Nature Reviews Cancer. 2018;18(1):33.
  8. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420(6913):333-6.
  9. Summers SA. Ceramides in insulin resistance and lipotoxicity. Progress in Lipid Research. 2006;45(1):42-72.
  10. Reidy PT, Mahmassani ZS, McKenzie AI, Petrocelli JJ, Summers SA, Drummond MJ. Influence of exercise training on skeletal muscle insulin resistance in aging: Spotlight on muscle ceramides. International Journal of Molecular Sciences. 2020;21(4):1514.
  11. Hannun YA, Obeid LM. Sphingolipids and their metabolism in physiology and disease. Nature reviews Molecular Cell Biology. 2018;19(3):175.
  12. Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, DeFronzo RA, et al. Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes. 2009;58(2):337-43.
  13. Adams SH. Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Advances in Nutrition. 2011;2(6):445-56.
  14. Van Der Heijden G-j, Wang ZJ, Chu Z, Toffolo G, Manesso E, Sauer PJ, et al. Strength exercise improves muscle mass and hepatic insulin sensitivity in obese youth. Medicine and Science in Sports and Exercise. 2010;42(11):1973.
  15. Pavlovskyi L, Shypulin V, Chernyavskyi V, Linevska K. The effect of different treatment strategies in patients with nonalcoholic fatty liver disease in combination with insulin resistance and type 2 diabetes mellitus on ceramide concentrations. Public Communication in Science: Philosophical, cultural, Political, Economic and IT Context. 2020;3:15-20.
  16. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The New England Journal of Medicine. 2002;346(6):393-403.
  17. Dobrzyń A, Górski J. Ceramides and sphingomyelins in skeletal muscles of the rat: content and composition. Effect of prolonged exercise. American Journal of Physiology-Endocrinology And Metabolism. 2002;282(2):E277-E85.
  18. Helge JW, Dobrzyn A, Saltin B, Gorski J. Exercise and training effects on ceramide metabolism in human skeletal muscle. Experimental Physiology. 2004;89(1):119-27.
  19. Bruce CR, Thrush AB, Mertz VA, Bezaire V, Chabowski A, Heigenhauser GJ, et al. Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. American Journal of Physiology-Endocrinology and Metabolism. 2006;291(1):E99-E107.
  20. Dube J, Amati F, Toledo F, Stefanovic-Racic M, Rossi A, Coen P, et al. Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. Diabetologia. 2011;54(5):1147-56.
  21. Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, et al. Muscle sphingolipids during rest and exercise: a C18: 0 signature for insulin resistance in humans. Diabetologia. 2016;59(4):785-98.
  22. Søgaard D, Baranowski M, Larsen S, Taulo Lund M, Munk Scheuer C, Vestergaard Abildskov C, et al. Muscle-saturated bioactive lipids are increased with aging and influenced by high-intensity interval training. International Journal of Molecular Sciences. 2019;20(5):1240.
  23. Pitsavos C, Panagiotakos DB, Tambalis K, Chrysohoou C, Sidossis L, Skoumas J, et al. Resistance exercise plus to aerobic activities is associated with better lipids’ profile among healthy individuals: the ATTICA study. QJM: An International Journal of Medicine. 2009;102(9):609-16.
  24. Rostamzadeh N, Sheikholeslami-Vatani D. Orexin and Lipid Profile Response to Six Months of Resistance Training and Subsequent Detraining in Sedentary Obese Men. Sport Physiology. 2020;12(47):93-112.
  25. Bea JW, Blew RM, Howe C, Hetherington-Rauth M, Going SB. Resistance training effects on metabolic function among youth: a systematic review. Pediatric Exercise Science. 2017;29(3):297-315.
  26. Rivas DA, Morris EP, Haran PH, Pasha EP, Morais MdS, Dolnikowski GG, et al. Increased ceramide content and NFκB signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males. Journal of Applied Physiology. 2012;113(11):1727-36.
  27. Ahmadizad S, Ghorbani S, Ghasemikaram M, Bahmanzadeh M. Effects of short-term nonperiodized, linear periodized and daily undulating periodized resistance training on plasma adiponectin, leptin and insulin resistance. Clinical Biochemistry. 2014;47(6):417-22.
  28. Rasooli SA, Fathi R, Golzar FA-K, Baghersalimi M. The effect of circuit resistance training on plasma levels of amino acids, alpha-hydroxybutyrate, mannose, and urinary levels of glycine conjugated adducts in obese adolescent boys. Applied Physiology, Nutrition, and Metabolism. 2021;99(999):1-10.
  29. Rasooli SA, Fathi R, Golzar FA-K. The Effect of circuit resistance training on the plasma levels of branched-chain amino acids and insulin resistance in obese adolescents boys. Sport Physiology. 2020;12(47):93-112.
  30. Yano M, Kishida E, Muneyuki Y, Masuzawa Y. Quantitative analysis of ceramide molecular species by high performance liquid chromatography. Journal of Lipid Research. 1998;39(10):2091-8.
  31. Zhang H, Fealy CE, Kirwan JP. Exercise training promotes a GDF15-associated reduction in fat mass in older adults with obesity. American Journal of Physiology-Endocrinology and Metabolism. 2019;316(5):E829-E36.
  32. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27(6):1487-95.
  33. Miller MB, Pearcey GE, Cahill F, McCarthy H, Stratton SB, Noftall JC, et al. The effect of a short-term high-intensity circuit training program on work capacity, body composition, and blood profiles in sedentary obese men: a pilot study. BioMed Research International. 2014;2014:191797.
  34. Prabhakaran B, Dowling EA, Branch JD, Swain DP, Leutholtz BC. Effect of 14 weeks of resistance training on lipid profile and body fat percentage in premenopausal women. British Journal of Sports Medicine. 1999;33(3):190-5.
  35. Foschini D, Araújo RC, Bacurau RF, De Piano A, De Almeida SS, Carnier J, et al. Treatment of obese adolescents: the influence of periodization models and ACE genotype. Obesity. 2010;18(4):766-72.
  36. Lira FS, Carnevali LC, Zanchi NE, Santos RV, Lavoie JM, Seelaender M. Exercise intensity modulation of hepatic lipid metabolism. Journal of Nutrition and Metabolism. 2012;2012. https://doi.org/10.1155/2012/809576.
  37. Espandar N, tofighi A, Tolouei Azar J, Santos RV, Khadem Ansari M. The effect of 8 weeks of resistance, endurance, and concurrent training on serum CTRP-12, Furin, KLF-15, lipid profiles and insulin resistance in sedentary obese men. Sport Physiology. 2021;13(49):107-36.
  38. Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, et al. Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia. 2021;64:1642-59.
  39. Mardare C, Krüger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, et al. Endurance and resistance training affect high fat diet-induced increase of ceramides, inflammasome expression, and systemic inflammation in mice. Journal of Diabetes Research. 2016;201. https://doi.org/10.1155/2016/4536470.
  40. Imierska M, Kurianiuk A, Błachnio-Zabielska A. The Influence of physical activity on the bioactive lipids metabolism in obesity-induced muscle insulin resistance. Biomolecules. 2020;10(12):1665.
  41. Hyde R, Hajduch E, Powell DJ, Taylor PM, Hundal HS. Ceramide down‐regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells. The FASEB Journal. 2005;19(3):1-24.
  42. Xia Q-S, Lu F-E, Wu F, Huang Z-Y, Dong H, Xu L-J, et al. New role for ceramide in hypoxia and insulin resistance. World Journal of Gastroenterology. 2020;26(18):2177.
  43. Camera DM, Edge J, Short MJ, Hawley JA, Coffey VG. Early time course of Akt phosphorylation after endurance and resistance exercise. Medicine and Science in Sports and Exercise. 2010;42(10):1843-52.
  44. Dickinson JM, Fry CS, Drummond MJ, Gundermann DM, Walker DK, Glynn EL, et al. Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids. The Journal of Nutrition. 2011;141(5):856-62.
  45. Poehlman ET, Dvorak RV, DeNino WF, Brochu M, Ades PA. Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: a controlled randomized trial. The Journal of Clinical Endocrinology & Metabolism. 2000;85(7):2463-8.
  46. Sparks LM, Johannsen NM, Church TS, Earnest CP, Moonen-Kornips E, Moro C, et al. Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism. 2013;98(4):1694-702.
  47. Shepherd S, Cocks M, Meikle P, Mellett N, Ranasinghe A, Barker T, et al. Lipid droplet remodelling and reduced muscle ceramides following sprint interval and moderate-intensity continuous exercise training in obese males. International Journal of Obesity. 2017;41(12):1745-54.
  48. Malin SK, Hinnerichs KR, Echtenkamp BG, Evetovich TK, Engebretsen BJ. Effect of adiposity on insulin action after acute and chronic resistance exercise in non-diabetic women. European Journal of Applied Physiology. 2013;113(12):2933-41.
  49. Shou J, Chen P-J, Xiao W-H. The effects of BCAAs on insulin resistance in athletes. Journal of Nutritional Science and Vitaminology. 2019;65(5):383-9.
  50. Hagg SA, Morse EL, Adibi SA. Effect of exercise on rates of oxidation, turnover, and plasma clearance of leucine in human subjects. American Journal of Physiology-Endocrinology And Metabolism. 1982;242(6):E407-E10.
Sport Physiology
Volume 14, Issue 54 - Serial Number 54
October 2022
Pages 171-194
Files
History
  • Receive Date: 05 August 2021
  • Revise Date: 12 November 2021
  • Accept Date: 16 November 2021
Share
How to cite
Statistics