Document Type : Research Paper
Authors
1 M.Sc.of Sport Physiology, Shahid Bahonar University of Kerman
2 Assistance Professor of Sport Physiology, Shahid Bahonar University of Kerman
Abstract
The aim of the present study was to investigate the effect of endurance training on changes of serum concentration of MIF and its relationship with plasma white blood cells, glucose, and insulin changes in type 2 diabetic women. Twenty-Four subjects (age 55±6.6 years and weight 73±5.1) randomly divided in two groups, including control (n=12) and trained (n=12). Trained group performed eight weeks of endurance training including running at of 55-75% of their heart rate maximum for 40 to 60 minutes. Blood samples were collected before training protocol and 72 hours after the last exercise session. Plasma glucose was measured with glucose oxidase method; Serum MIF and plasma insulin concentration were measured by ELISA method. Difference of variables between groups were evaluated by analysis of covariance and multiple regression analysis was used to determine the possible contribution of white blood cells, glucose, and insulin changes to serum MIF changes after training protocol. Compared to the control group, concentration of serum MIF (P=0.03), plasma glucose (P=0.02), plasma insulin (P=0.04), white blood cell population (P=0.002), and HOMA_IR index values (P=0.01) in trained group significantly decreased after eight week of endurance training. Significant correlation was found between the exercise-induced changes in white blood cell population and serum MIF concentration (P=0.05). Sixty-three present of the variance in the changes in serum MIF concentration could be predicted by only the changes in white blood cell population. In summary, long-term endurance training is accompanied by decrease in white blood cell population and these changes could predict the exercise-induced suppression in serum MIF concentration after endurance training.
Keywords
- Endurance training
- Macrophage Migration Inhibitory Factor
- White Blood Cell Population
- type 2 diabetes
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