Document Type : Research Paper
Authors
- Yaghoob Mehri Alvar
- zahra sayeevand
- Fahimeh Erfani Adab
- Rashid Heidari Moghadam
- Mohammad Ali Samavat Sharif
- Sajad Karami
Abstract
The aim of this study was to investigate the effects of resistance training on serum Vascular Endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (BFGF) and plasma level Growth Hormone (GH) and cortisol on sedentary individual men. Therefore, we chose twenty sedentary students who divided in two groups resistance training (RT) (age 24.1 year, height 172.7 cm, weight 67.20 kg, BMI 18.93 kg/m2, %fat 17.6) and control (age 23.6 year, height 173.3 cm, weight 66.2 kg, BMI 20.66 kg/m2, %fat 20.59). After initial blood sampling, Resistance training circle group were active in the period of five weeks, the control group did not exercise in these periods. Finally, to remove temporarily the effects of exercise blood samples were taken 48 hours after the last training session. All data analysis at the significant level P≤0.05 was performed using SPSS 18 software. Independent t-test results showed that resistance training following values level of VEGF (P=0.033) Growth Hormone (P=0.001) compared to control group increased significantly whereas cortisol (0.266) and bFGF (0.086) in between resistance and control group variation non-significant. The test results show that followed by resistance training in posttest, there is a high correlation between values growth hormone and VEGF (r=0.74), the correlation is significant (P=0.014). It seems that resistance training can be increase vascular endothelial growth factor and growth hormone, thereby enhance angiogenesis.
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1) Olfert I, Mark Richard A, Howlett D, Wagner E, Ellen C, Breen D. Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis. American Journal of Physiology. 2010; 4: 1059-67.
2) Turner M, Cortney A, Stanley J, Watson H. The fibroblast growth factor family: Neuro modulation of affective behavior. 2012; 76(1): 160-74.
3) Dan N, Alon E, Frank Z, Dan M. Effect of rhIL-6 infusion on GH-IGF-I axis mediators in humans. Regulatory, Integrative and Comparative Physiology. 2006; 291: 1663-8.
4) Loufrani L, Henrion D. Role of the cytoskeleton in flow (shear stress) induced dilation and remodeling in resistance arteries. Medical and Biological Engineering and Computin. 2008; 46(5): 451-60.
5) Esfahanni P, Jahangir K, Khazaei M. Alterations of plasma nitric oxide, vascular endothelial growth factor, and soluble form of its receptor (sFlt-1) after resistance exercise: An experimental study. Advanced Biomedical Research. 2014; 31(3): 140-50
6) شکرچیزاده پریوش، خزاعی مجید، قراخانلو رضا، کریمیان جهانگیر، صفرزاده علیرضا. اثر تمرینات مقاومتی بر سطوح پلاسمایی نیتریک اکساید، فاکتور رشد اندوتلیال عروق و گیرندههای نوع 1 آن در رتهای نر سالم. نشریۀ علوم پزشکی اصفهان.1391؛ 8 (6): 30ـ17.
7) مهرو مهرنوش، گایینی عباسعلی، چوبینه سیروس، جاویدی محسن. تغییرات عوامل تحریکی رگزایی ناشی از تمرین مقاومتی فزاینده در رتهای دیابتی. نشریۀ دیابت و متابولیسم ایران .1393؛ 14(1): 8ـ1.
8) Thum T, Sarah H, Ivonne K, Dirk O. Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone mediated increase of insulin-like growth factor-1. Circulation Research. 2007; 100(3): 434-43.
9) Poulaki V, Joussen A, Mitsiades N, Mitsiades C, Iliaki E, Adamis A. Insulin-like growth Factor-I plays a pathogenetic role in diabetic retinopathy. The American Journal of Pathology. 2004; 165(2): 457-69.
10) حمزهزاد بروجنی الهام، نظرعلی پروانه، کردی محمدرضا. تأثیر 4 هفته تمرین تناوبی شدید (HIIT) بر سطوح GH، IGF-1،IGFBP-3 و کورتیزول سرم زنان تیم ملی بسکتبال ایران. نشریۀ فیزیولوژی ورزشی. 1392؛ 19: 58ـ143.
11) Thum T, Tsikas D, Frölich J, Borlak J. Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line. FEBS Letters. 2003; 555(3): 567-71.
12) Egginton S. Invited review: Activity-induced angiogenesis. Pflügers Archiv European Journal of Physiology. 2009; 457(5): 963-77.
13) Prior B, Yang R, Terjung T. What makes vessels grow with exercise training? Journal of Applied Physiology. 2004; 97: 1119-28.
14) Logsdon F, Elizabeth A, Stacey D, Finley G, Aleksander S, Popel T, et al. A systems biology view of blood vessel growth and remodeling. Journal of Cellular and Molecular Medicine. 2014; 18(8): 1491-508.
15) Griffin É, Mullally S, Foley C, Warmington S, O'Mara S, Kelly Á. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiology & Behavior. 2011; 104(5): 934-41.
16) عنابستانی محبوبه، حسینی کاخک سیدعلیرضا، حامدینیا محمدرضا. مقایسۀ تمرینات ترکیبی با انسداد عروق و بدون انسداد عروق بر عوامل منتخب آمادگی جسمانی زنان یائسه. نشریۀ فیزیولوژی ورزشی. 1393؛ 6(21): 36ـ123.
17) Qi Z, He J, Zhang Y, Shao Y, Ding S. Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats. Free Radical Biology and Medicine. 2011; 50(7): 794-800.
18) Kraemer W, Ratamess N. Fundamentals of resistance training: Progression and exercise prescription. Medicine and Science in Sports and Exercise. 2004; 36(4): 674-88.
19) قراخانلو رضا، صارمی عباس، امیدفر کبری، شرقی ساسان، قرائتی محمدرضا. اثر تمرین مقاومتی بر سطوح سرمی میوستاتین، تستوسترون و کورتیزول در مردان جوان. فصلنامۀ المپیک.1387؛ (43): 43ـ16.
20) McCall G, Byrnes W, Fleck S, Dickinson A, Kraemer W. Acute and chronic hormonal responses to resistance training designed to promote muscle hypertrophy. Canadian Journal of Applied Physiology. 1999; 24(1): 96-107.
21) مرندی محمد، محبی حمید، قراخانلو رضا، نادری غلامعلی. واکنشهای IGF-1، GH و تستسترون به یک جلسه فعالیت بدنی شدید. فصلنامۀ المپیک. 1383؛ 4(28): 15ـ8.
22) Höffner L, Nielsen H, Langberg Y, Hellsten M. Exercise but not prostanoids enhance levels of vascular endothelial growth factor and other proliferative agents in human skeletal muscle interstitium. The Journal of Physiology. 2003; 550(1): 217-25.
23) Brunet-Dunand S, Vouyovitch C, Araneda S, Pandey V, Vidal L, Print C. Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma. Endocrinology. 2009; 150(3): 1341-52.
24) McArdle W, Katch V, Katch L. Exercise physiology: Nutrition, energy, and human performance. Philadelphia: Wolters Kluwer Health/Lippincott, Williams & Wilkins; 2010: 137-49
25) Pedersen B K, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P, et al. The metabolic role of IL-6 produced during exercise: Is IL-6 an exercise factor? Proceeding of the Nutrition Society. 2004; 63(2): 263–7.
26) Schulze‐Tanzil G, Al‐Sadi E, Wiegand W, Ertel C, Busch B, Kohl T, et al. The role of pro‐inflammatory and immunoregulatory cytokines in tendon healing and rupture: New insights. Scandinavian Journal of Medicine & Science in Sports. 2011; 21(3): 337-51.
27) Gavin T, Drew C, Kubik W, Pofahl R, Hickner T. Acute resistance exercise increases skeletal muscle angiogenic growth factor expression. Acta Physiologica. 2007; 191(2): 139-46.
28) Lin K, Jiumao L, Jianheng Z, Wei Xu, Zhenfeng H, Jun P. Qianliening capsule inhibits benign prostatic hyperplasia angiogenesis via the HIF‑1α signaling pathway. Experimental and Therapeutic Medicine. 2014; 8)1): 118-24.
29) روزبهانی پریسا، میرزایی بهمن. تأثیر فعالیت تناوبی شدید در شرایط هایپوکسی نورموباریک و نورموکسی بر مقادیر اینتربوکین-6 و ارتباط آن با گلوکز در جوانان غیرورزشکار. نشریۀ فیزیولوژی ورزشی. 1393؛ 6(24): 30ـ15.
30) Helge J, Stallknecht B, Pedersen B K, Galbo H, Kiens B, Richter E A. The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. The Journal of Physiology. 2003; 546: 299-305.
31) Brown M, Hudlicka O. Modulation of physiological angiogenesis in skeletal muscle by mechanical forces: Involvement of VEGF and metalloproteinases. Angiogenesis. 2003; 6(1): 1-14.
32) Sakayama K, Mashima N, Kidani T, Miyazaki T, Yamamoto H, Masuno H. Effect of cortisol on cell proliferation and the expression of lipoprotein lipase and vascular endothelial growth factor in a human osteosarcoma cell line. Cancer Chemotherapy and Pharmacology. 2008; 61(3): 471-9.
33) Gao T, Lin Z, Jin X. Hydrocortisone suppression of the expression of VEGF may relate to toll-like receptor (TLR) 2 and 4. Current Eye Research. 2009; 34(9): 777-84.
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