اثرات فعالیت ورزشی هوازی و محدودیت کالری (رژیم غذایی کم کربوهیدرات و رژیم غذایی استاندارد) بر آدیپوکاین‌های مؤثر بر مقاومت انسولین در موش صحرایی نر دیابتی نوع دو

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری بیوشیمی و متابولیسم ورزشی، دانشگاه اصفهان

2 استاد فیزیولوژی ورزشی، دانشگاه اصفهان

3 دانشیار فیزیولوژی ورزشی، دانشگاه اصفهان

4 استادیار فیزیولوژی پزشکی، دانشگاه علوم پزشکی جهرم

چکیده

هدف از مطالعه‌ی حاضر، بررسی تاًثیر تعاملی محدودیت کالری (رژیم غذایی استاندارد و رژیم غذایی کم کربوهیدرات) و در ترکیب با فعالیت ورزشی هوازی بر میزان آدیپوکاین‌های مؤثر بر مقاومت انسولین در موش صحرایی نر دیابت نوع دو بود. در یک مطالعه تجربی، 48 سر موش صحرایی نر (سن 10هفته) نژاد ویستار (وزن 5/19±229 گرم) پس از دیابتی شدن به طور تصادفی به شش گروه: کنترل، فعالیت ورزشی هوازی (20% تعادل منفی انرژی)، 20% محدودیت کالری با رژیم غذایی استاندارد، 20% محدودیت کالری با رژیم غذایی کم کربوهیدرات، 20% محدودیت کالری با رژیم غذایی استاندارد ترکیب با فعالیت ورزش هوازی و 20% محدودیت کالری با رژیم غذایی کم کربوهیدرات ترکیب با ورزشی هوازی تقسیم شدند. سپس 20% تعادل منفی انرژی به صورت روزانه و به مدت 8 هفته برای تمام گروه‌ها اجرا شد. یافته‌ها نشان داد فعالیت ورزشی هوازی به تنهایی و در ترکیب با رژیم غذایی کم کربوهیدرات باعث افزایش معنی‌داری در میزان امنتین-1 نسبت به گروه کنترل دیابتی شد (P≤0.05)، اما تفاوت معنی‌داری بین گروه‌های تجربی با گروه کنترل دیابتی در میزان کمرین مشاهده نشد. همچنین نتایج نشان داد گروه رژیم غذایی (استاندارد و کم کربوهیدرات) به تنهایی و در ترکیب با فعالیت ورزشی باعث کاهش معنی‌داری در میزان مقاومت انسولین شد (P≤0.05). این مطالعه نشان داد که روش ترکیبی فعالیت ورزشی هوازی و رژیم غذایی کم کربوهیدرات می‌تواند باعث افزایش امنتین-1 و بهبود حساسیت انسولین در موش صحرایی نر مبتلا به بیماری دیابت نوع دو شود.

کلیدواژه‌ها

موضوعات

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فیزیولوژی ورزشی
دوره 9، شماره 36 - شماره پیاپی 36
زمستان 1396
بهمن 1396
صفحه 173-188

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  • تاریخ دریافت: 15 خرداد 1396
  • تاریخ بازنگری: 14 شهریور 1396
  • تاریخ پذیرش: 27 شهریور 1396

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